Mechanism of distant recurrence in rectal cancer patients after preoperative chemoradiotherapy

• Project/Area Number: 21591723
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: INOUE Yasuhiro 三重大学, 医学部附属病院, 講師 (20324535)
• Co-Investigator(Kenkyū-buntansha): KUSUNOKI Masato 三重大学, 大学院・医学系研究科, 教授 (50192026) ; MIKI Chikao 三重大学, 大学院・医学系研究科, 客員教授 (50242962) ; 問山 裕二 三重大学, 大学院・医学系研究科, 助教 (00422824)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 直腸癌 / 化学放射線療法 / 遠隔転移 / 遠隔転移再発 / 放射線療法 / 癌幹細胞

Research Abstract

We investigated the mechanism of distant recurrence in rectal cancer patients after preoperative chemoradiotherapy to improve the prognosis of patients with advanced rectal cancer further. The mechanism were analyzed from several viewpoints including 1) anti-cancer agents, 2) angiogenesis, 3) stemcell, 4) chemokines, 5) epitherial-mesenchymal transition(EMT), 6) cancer-stromal interaction, et al. Our study suggested that these all factors were associated with distant recurrence with several interactions. Therefore, we need to investigate the mechanism from various angles further, to control distant recurrence in rectal cancer patients after preoperative chemoradiotherapy.

Research Products

• [Journal Article] Prognostic significance of glucose transporter-1(GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. (2012)
  • Author(s): Saigusa S, Toiyama Y, Tanaka K, Okugawa Y, Fujikawa H, Matsushita K, Uchida K, Inoue Y, Kusunoki M
  • Journal Title: Surg Today Volume: 42 Pages: 460-9
  • NAID: 10030621686
  • Peer Reviewed
• [Journal Article] Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy (2012)
  • Author(s): Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Fujikawa H, Matsushita K, Okugawa Y, Inoue Y, Uchida K, Mohri Y, Kusunoki M
  • Journal Title: Int J Oncol Volume: 40 Pages: 583-91
  • Peer Reviewed
• [Journal Article] Radiation induces epithelial-mesenchymal transition in colorectal cancer cells (2012)
  • Author(s): Kawamoto A, Yokoe T, Tanaka K, Saigusa S, Toiyama Y, Yasuda H, Inoue Y, Miki C, Kusunoki M
  • Journal Title: Oncol Rep Volume: 27 Pages: 51-57
  • DOI: 10.3892/or.2011.1485
  • Peer Reviewed
• [Journal Article] Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy (2011)
  • Author(s): Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Okugawa Y, Fujikawa H, Matsusita K, Kawamura M, Inoue Y, Miki C, Kusunoki M
  • Journal Title: Int J Oncol Volume: 38 Pages: 655-663
  • Peer Reviewed
• [Journal Article] Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy (2011)
  • Author(s): Saigusa S, Mohri Y, Ohi M, Toiyama Y, Ishino Y, Okugawa Y, Tanaka K, Inoue Y, Kusunoki M
  • Journal Title: Oncol Rep Volume: 26 Pages: 1069-1074
  • Peer Reviewed
• [Journal Article] Radiation induces epithelial-mesenchymal transition in colorectal cancer cells (2011)
  • Author(s): Kawamoto A, Yokoe T, Tanaka K, Saigusa S, Toiyama Y, Yasuda H, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep Volume: 27 Pages: 51-57
  • Peer Reviewed
• [Journal Article] Podoplanin and SOX2 expression in esophageal squamous cell carcinom a after neoadjuvant chemo-radiotherapy (2011)
  • Author(s): Saigusa S, Mohri Y, Ohi M, Toiyama Y, Ishino Y, Okugawa Y, Tanaka K, Inoue Y, Kusunoki M
  • Journal Title: Oncol Rep Volume: 26 Pages: 1069-1074
  • DOI: 10.3892/or.2011.1408
  • Peer Reviewed
• [Journal Article] Clinical Significance of CD133 and Hypoxia Inducible Factor-1α Gene Expression in Rectal Cancer after Preoperative Chemoradiotherapy (2010)
  • Author(s): Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Koike Y, Fujikawa H, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Clin Oncol (R Coll Radiol) Volume: 20 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Immunohistochemical features of CD133 expression: association with resistance to chemoradiotherapy in rectal cancer (2010)
  • Author(s): Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Kawamoto A, Yasuda H, Morimoto Y, Fujikawa H, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep Volume: 24 Pages: 345-350
  • Peer Reviewed
• [Journal Article] Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy (2010)
  • Author(s): Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Okugawa Y, Kawamoto A, Yasuda H, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 2051-2058
  • Peer Reviewed
• [Journal Article] Clinical Significance of CD133 and Hypoxia Inducible Factor-1α Gene Expression in Rectal Cancer after Preoperative Chemoradiotherapy. (2010)
  • Author(s): Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Koike Y, Fujikawa H, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Clin Oncol (R Coll Radiol) Volume: Oct 20 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer. (2010)
  • Author(s): Hiro J, Inoue Y, Toiyama Y, Yoshiyama S, Tanaka K, Mohri Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep Volume: 24(4) Pages: 1029-1034
  • Peer Reviewed
• [Journal Article] Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy. (2010)
  • Author(s): Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Okugawa Y, Kawamoto A, Yasuda H, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Ann Surg Oncol. Volume: 17(8) Pages: 2051-2058
  • Peer Reviewed
• [Journal Article] Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues (2009)
  • Author(s): Inoue Y, Tanaka K, Yokoe T, Saigusa S, Toiyama Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep Volume: 22 Pages: 901-906
  • Peer Reviewed
• [Journal Article] Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer (2009)
  • Author(s): Yasuda H, Tanaka K, Saigusa S, Toiyama Y, Koike Y, Okugawa Y, Yokoe T, Kawamoto A, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep Volume: 22 Pages: 709-717
  • Peer Reviewed
• [Journal Article] Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy (2009)
  • Author(s): Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Ioue Y, Miki C, Kusunoki M.
  • Journal Title: Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy Volume: 16 Pages: 3488-3498
  • Peer Reviewed
• [Journal Article] Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues (2009)
  • Author(s): Inoue V, Tanaka K, Yokoe T, Saigusa S, Toiyama Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep. 22 Pages: 901-906
  • Peer Reviewed
• [Journal Article] Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer (2009)
  • Author(s): Yasuda H, Tanaka K, Saigusa S, Toiyama Y, Koike Y, Okugawa Y, Yokoe T, Kawamoto A, Inoue Y, Miki C, Kusunoki M.
  • Journal Title: Oncol Rep. 22 Pages: 709-717
  • Peer Reviewed
• [Journal Article] Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy (2009)
  • Author(s): Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Ioue Y, Miki C, Kusunoki M.
  • Journal Title: Ann Surg Oncol. 16 Pages: 3488-3498
  • Peer Reviewed
• [Presentation] Clinical and molecular comparison between short-and long-course preoperative radiotherapy for rectal cancer (2011)
  • Author(s): Inoue Y, Saigusa S, Hiro J, Toiyama Y, Tanaka K, Mohri Y, Kusunoki M
  • Organizer: American Society of Clinical Oncology
  • Place of Presentation: シカゴ・米国
• [Presentation] Clinical and molecular comparison between short- and long-course preoperative radiotherapy for rectal cancer (2011)
  • Author(s): Y.Inoue, S.Saigusa, J.Hiro, Y.Toiyama, K.Tanaka, Y.Mohri, M.Kusunoki
  • Organizer: American Society of Clinical Oncology
  • Place of Presentation: シカゴ・米国(誌上発表Abstr e14093)
• [Presentation] 直腸癌術前化学放射線療法における至適照射スケジュールの検討 (2010)
  • Author(s): 井上靖浩、三枝晋、沖上正人、川本文、廣純一郎、問山裕二、小林美奈子、田中光司、三木誓雄、楠正人
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-28
• [Presentation] 直腸癌術前化学放射線療法後CD133、HIF-1α発現の臨床病理学的検討 (2010)
  • Author(s): 三枝晋、田中光司、問山裕二、横江毅、奥川喜永、小池勇樹、藤川裕之、岩田崇、松下航平、井上靖浩、三木誓雄、楠正人
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-28
• [Presentation] CD133, OCT4, and NANOG in ulcerative colitis-associated colorectal cancer (2009)
  • Author(s): Tanaka K, Yasuda H, Okita Y, Araki T, Saigusa S, Toiyama Y, Yokoe T, Kawamoto A, Ioue Y, Miki C, Kusunoki M
  • Organizer: AACR 100th Annual Meeting 2009
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2009-04-21