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Carbon dioxide insufflating endoscopy for patients with inflammatory bowel diseases : safety and efficacy study

Research Project

Project/Area Number 21591724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionOsaka University

Principal Investigator

NAKAJIMA Kiyokazu  大阪大学, 医学系・研究科, 助教 (30432537)

Co-Investigator(Kenkyū-buntansha) MIZUSHIMA Tunekazu  大阪大学, 医学系・研究科, 助教 (00527707)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords消化管 / 炎症性腸疾患 / 消化器内視鏡 / 二酸化炭素送気法 / 炭酸ガス / クローン病 / 潰瘍性大腸炎
Research Abstract

The present study confirmed that carbon dioxide insufflating endoscopy is feasible and safe for patients with inflammatory bowel diseases(Crohn' s disease and ulcerative colitis). Its clinical effectiveness was also evaluated by comparing performance of conventional(air-insufflating) vs. CO2 insufflating endoscopy in a randomized fashion. There found no significant differences in mucosal redness, residual bowel gas and morbidity index, suggesting that CO2-insufflating endoscopy is at least not inferior to the conventional endoscopy. Further accumulation of patients is necessary to demonstrate its true clinical role.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] クローン病に対する腹腔鏡下手術の適応と限界2010

    • Author(s)
      中島清一、根津理一郎, 他
    • Journal Title

      日本大腸肛門病学会雑誌

      Volume: 63 Pages: 888-92

    • NAID

      10027718626

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current limitations in endoscopic CO2 insufflation for NOTES : flow andpressure study2010

    • Author(s)
      Nakajima K, Nishida T, et al
    • Journal Title

      Gastrointest Endosc

      Volume: 72 Pages: 1036-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of hand-assisted laparoscopic surgery in subtotal/ total colectomy for Crohn' s colitis2010

    • Author(s)
      Nakajima K, Nezu R, et al
    • Journal Title

      Surg Endosc

      Volume: 24 Pages: 2713-17

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hand-assisted laparoscopic restorative proctocolectomy for ulcerative colitis : optimization of instrumentation towards standardization2010

    • Author(s)
      Nakajima K, Nezu R, et al
    • Journal Title

      Surg Today

      Volume: 40 Pages: 840-4

    • NAID

      10027397636

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current limitations in endoscopic CO2 insufflation for NOTES : flow and pressure study2010

    • Author(s)
      Nakajima K, Nishida T, et al
    • Journal Title

      Gastrointest Endosc

      Volume: 72 Pages: 1036-1042

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of hand-assisted laparoscopic surgery in subtotal/total colectomy for Crohn's colitis2010

    • Author(s)
      Nakajima K, Nezu R, et al
    • Journal Title

      Surg Endosc

      Volume: 24 Pages: 2713-1717

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of intraoperative carbon dioxide insufflating upper gastrointestinal endoscopy during laparoscopic surgery2009

    • Author(s)
      Souma Y, Nakajima K, et al
    • Journal Title

      Surg Endosc

      Volume: 23 Pages: 279-85

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial gastrectomy using natural orifice translumenal endoscopic surgery(NOTES) for gastric submucosal tumors : early experience in humans2009

    • Author(s)
      Nakajima K, Nishida T, et al
    • Journal Title

      Surg Endosc

      Volume: 23 Pages: 2650-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of intraoperative carbon dioxide insufflating upper gastrointestinal endoscopy during laparoscopic surgery2009

    • Author(s)
      Souma Y, Nakajima K, et al
    • Journal Title

      Surg Endosc 23

      Pages: 2279-2285

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial gastrectomy using natural orifice translumenal endoscopic surgery (NOTES) for gastric submucosal tumors : early experience in humans2009

    • Author(s)
      Nakajima K, Nishida T, et al
    • Journal Title

      Surg Endosc 23

      Pages: 2650-2655

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Steady pressure automatically controlled endoscopy(SPACE): its concept and possibility2010

    • Author(s)
      Nakajima K
    • Organizer
      4th International NOTES W. I. D. E. R.
    • Place of Presentation
      Barcelona(スペイン)
    • Year and Date
      2010-12-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Steady pressure automatically controlled endoscopy (SPACE) : its concept and possibility2010

    • Author(s)
      Nakajima K
    • Organizer
      4th International NOTES W.I.D.E.R.
    • Place of Presentation
      Barcelona(スペイン)(招待講演)
    • Year and Date
      2010-12-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] NOTES and its spin-off technologies2010

    • Author(s)
      Nakajima K
    • Organizer
      62nd Korean Surgical Society
    • Place of Presentation
      Seoul(韓国)
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] NOTES and its spin-off technologies2010

    • Author(s)
      Nakajima K
    • Organizer
      62nd Korean Surgical Society
    • Place of Presentation
      Seoul(韓国)(招待講演)
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Minimally invasive surgery for IBD : an update2010

    • Author(s)
      Nakajima K, Hirota M, et al
    • Organizer
      5th Japan-Korea IBD Symposium
    • Place of Presentation
      Seoul(韓国)
    • Year and Date
      2010-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Minimally invasive surgery for IBD : an update2010

    • Author(s)
      Nakajima K, Hirota M, et al
    • Organizer
      5th Japan-Korea IBD Symposium
    • Place of Presentation
      Seoul(韓国)(招待講演)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 潰瘍性大腸炎に対する低侵襲手術の標準化~learning curveの解析を通じて~2010

    • Author(s)
      中島清一、根津理一郎, 他
    • Organizer
      日本外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Insufflation technique(CO2 endoscopy)2009

    • Author(s)
      Nakajima K
    • Organizer
      3rd International NOTES-WIDER conference
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2009-09-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Insufflation technique (CO2 endoscopy)2009

    • Author(s)
      Nakajima K
    • Organizer
      3rd Internatiol NOTES-WIDER conference
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2009-09-07
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 内視鏡用挿入補助具2009

    • Inventor(s)
      中島清一
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2009-195605
    • Filing Date
      2009-08-26
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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