Novel strategy for prediction of toxicity and efficacy of chemotherapy for patients with metastatic colorectal cancer.
| Project/Area Number |
21591725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HAZAMA Shoichi 山口大学, 大学院・医学系研究科, 准教授 (50253159)
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Naoko 山口大学, 医学部附属病院, 副臨床・衛生検査技師長 (40420541)
SAKAMOTO Kazuhiko 山口大学, 医学部附属病院, 助教 (50420526)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | イリノテカン / セツキシマブ / UGT1A1 / KRAS / BRAF / PI3K / Irinotecan / UGT1As / Cetuximab / cetuximab / P13K / EGFR / 遺伝子多型 / 大腸癌 / 化学療法 |
|---|
| Research Abstract |
1. The toxicity of irinotecan, G3/ 4 neutropenia, was predicted by UGT1A1^* 28/^* 6 alleles as well as UGT1A7 N129K(G),-57(G), UGT1A9^* 22 alleles. Genotype subset selection of multi-UGT1As polymorphisms can predict severe neutropenia and tumor responses of metastatic CRC patients received FOLFIRI regimen.
2. Mutations such as BRAF, and PI3K were also important biomarkers of cetuximab. Furthermore, our date suggest that the FcGR3_a polymorphisms may be also useful molecular markers to predict clinical outcome in mCRC pts treated with cetuximab.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Cediranib in combination with mFOLFOX6 in Japanese patients with metastatic colorectal cancer : results from the randomised phase II part of a phase I/ II study2011
Author(s)
Kato T, Muro K, Yamaguchi K, Bando H, Hazama S, Amagai K, Baba H, Denda T, Shi X, Fukase K, Sakamoto J, Mishima H
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Journal Title
Ann Oncol
Volume: 23(4): 933-41
Related Report
Peer Reviewed
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[Journal Article] Impact of chemotherapy for colorectal cancer on regulatory T-cells and tumor immunity2011
Author(s)
Maeda K, Hazama S, Tokuno K, Kan S, Maeda Y, Watanabe Y, Kamei R, Shindo Y, Maeda N, Yoshimura K, Yoshino S, Oka M
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Journal Title
Anticancer Res
Volume: 31(12): 4569-74
Related Report
Peer Reviewed
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[Journal Article] Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/ 6 polymorphisms2011
Author(s)
Okuyama Y, Hazama S, Nozawa H, Kobayashi M, Takahashi K, Fujikawa K, Kato T, Nagata N, Kimura H, Oba K, Sakamoto J, Mishima H
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Journal Title
Jpn J Clin Oncol
Volume: 41(4): 477-82
Related Report
Peer Reviewed
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[Journal Article] The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues2010
Author(s)
Okayama N, Nishioka M, Hazama S, Sakai K, Suehiro Y, Maekawa M, Sakamoto J, Iwamoto S, Kato T, Mishima H, Oka M, Hinoda Y
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Journal Title
Jpn J Clin Oncol
Volume: 41(2): 165-71
Related Report
Peer Reviewed
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[Journal Article] Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells2009
Author(s)
Ueno K, Hazama S, Mitomori S, Nishioka M, Suehiro Y, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y
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Journal Title
Br J Cancer
Volume: 101(8): 1374-81
Related Report
Peer Reviewed
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