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Development of cancer stem cell vaccine therapy based on the Niche theory

Research Project

Project/Area Number 21591729
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionWakayama Medical University

Principal Investigator

MATSUDA Kenji  和歌山県立医科大学, 医学部, 助教 (30398458)

Co-Investigator(Kenkyū-buntansha) YAMAUE Hiroki  和歌山県立医科大学, 医学部, 教授 (20191190)
IWAHASHI Makoto  和歌山県立医科大学, 医学部, 准教授 (70244738)
HOTTA Tsukasa  和歌山県立医科大学, 医学部, 講師 (50244744)
NAKUMURA Masaki  和歌山県立医科大学, 医学部, 講師 (80364090)
OJIMA Toshiyasu  和歌山県立医科大学, 医学部, 助教 (60448785)
KATSUDA Masahiro  和歌山県立医科大学, 医学部, 助教 (50464673)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords癌幹細胞 / Niche / WT1
Research Abstract

We assessed immunoresponse to WT1 protein to develop cancer stem cell vaccine therapy. WT1 protein have a potential power to maintain the malignancies of its cancer cell, and it is expressed several malignancies. We confirmed HLA-A24 restricted WT1 derived peptide specific immunoresponses. Furthermore, we tried to separate cancer stem cell by using CD133 antibody. We confirmed the spheres formation in some parts of cancer cell. We believe that this may be consolidated the foundation of Niche control.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (5 results)

  • [Journal Article] Comparison of different classes of CpG-ODN in augmenting the generation of human epitope peptide-specific CTLs2011

    • Author(s)
      Katsuda M, Iwahashi M, Matsuda K, Miyazawa M, Nakamori M, Nakamura M, Ojima T, Iida T, Hayata K, Yamaue H
    • Journal Title

      Int J Oncol

      Volume: 39(5) Pages: 1295-302

    • Related Report
      2011 Final Research Report
  • [Journal Article] TLR-9 Agonistを併用した新規食道癌ペプチドワクチン療法2011

    • Author(s)
      勝田将裕, 岩橋誠, 松田健司, 宮澤基樹, 中森幹人, 中村公紀, 中禎二, 尾島敏康, 飯田武, 山上裕機
    • Journal Title

      癌と化学療法

      Volume: 38巻、12号 Pages: 1942-1944

    • Related Report
      2011 Final Research Report
  • [Journal Article] Comparison of different classes of CpG-ODN in augumenting2011

    • Author(s)
      Katsuda M,, Matsuda K, et al
    • Journal Title

      Int J Oncol

      Volume: 39 Pages: 1295-1302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymph node ratio is associated with the survival2011

    • Author(s)
      Matsuda, et al
    • Journal Title

      Am Surgeon

      Volume: 77 Pages: 602-607

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re-expression of CEACAM1 long cytoplasmic domain2011

    • Author(s)
      Ieda J, Matsuda K, et al
    • Journal Title

      Int J Cancer

      Volume: 129 Pages: 1351-1361

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of anastomotic recurrences2010

    • Author(s)
      Matsuda K, et al.
    • Journal Title

      Langenbecks Arch Surg

      Volume: 395 Pages: 235-239

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of p53 codon 72 polymorphism2010

    • Author(s)
      Tominaga T, Matsuda K, et al
    • Journal Title

      Int J Cancer

      Volume: 126 Pages: 1691-1701

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term comorbidity of diabetes mellitus~2009

    • Author(s)
      Matsuda K, et al.
    • Journal Title

      Langenbecks Arch Surg 394

      Pages: 65-70

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of orally administered surperfine dispersesd Lentinan~2009

    • Author(s)
      Hazama S, ~, Matsuda K, ~
    • Journal Title

      Anticancer Res 29

      Pages: 2611-2618

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] CpG-ODNによる癌ペプチドワクチン療法の効果増強とその機序の解析2011

    • Author(s)
      勝田将裕, 岩橋誠, 中森幹人, 中村公紀, 尾島敏康, 飯田武, 辻俊明, 早田啓治, 松田健司, 宮澤基樹, 山上裕機
    • Organizer
      第49回日本癌治療学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 大腸癌腹膜播種切除の検討2011

    • Author(s)
      松田健司, ら
    • Organizer
      第66回日本大腸肛門病学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腹膜播種合併大腸癌の予後予測因子の解析2010

    • Author(s)
      松田健司, ら
    • Organizer
      日本外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLR-9アゴニスト併用食道癌ペプチドワクチン療法2010

    • Author(s)
      勝田将裕, 岩橋誠, 中森幹人, 中村公紀, 松田健司, 飯田武, 宮澤基樹, 角田卓也, 中村祐輔, 山上裕機
    • Organizer
      第65回日本消化器外科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 切除可能同時性肝転移に対する原発巣同時切除は妥当か?2009

    • Author(s)
      松田健司, ら
    • Organizer
      日本消化器外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2020-10-02  

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