Development of cancer stem cell vaccine therapy based on the Niche theory
| Project/Area Number |
21591729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MATSUDA Kenji 和歌山県立医科大学, 医学部, 助教 (30398458)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
IWAHASHI Makoto 和歌山県立医科大学, 医学部, 准教授 (70244738)
HOTTA Tsukasa 和歌山県立医科大学, 医学部, 講師 (50244744)
NAKUMURA Masaki 和歌山県立医科大学, 医学部, 講師 (80364090)
OJIMA Toshiyasu 和歌山県立医科大学, 医学部, 助教 (60448785)
KATSUDA Masahiro 和歌山県立医科大学, 医学部, 助教 (50464673)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌幹細胞 / Niche / WT1 |
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| Research Abstract |
We assessed immunoresponse to WT1 protein to develop cancer stem cell vaccine therapy. WT1 protein have a potential power to maintain the malignancies of its cancer cell, and it is expressed several malignancies. We confirmed HLA-A24 restricted WT1 derived peptide specific immunoresponses. Furthermore, we tried to separate cancer stem cell by using CD133 antibody. We confirmed the spheres formation in some parts of cancer cell. We believe that this may be consolidated the foundation of Niche control.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] CpG-ODNによる癌ペプチドワクチン療法の効果増強とその機序の解析2011
Author(s)
勝田将裕, 岩橋誠, 中森幹人, 中村公紀, 尾島敏康, 飯田武, 辻俊明, 早田啓治, 松田健司, 宮澤基樹, 山上裕機
Organizer
第49回日本癌治療学会総会
Related Report
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