Prediction of high-risk stage II colorectal cancer by gene expression profile
| Project/Area Number |
21591733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Toshiaki 帝京大学, 医学部, 教授 (80210920)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大腸癌 / ハイリスク / 術後補助化学療法 / DNAマイクロアレイ / 遺伝子発現 |
|---|
| Research Abstract |
Based on the gene expression of stage II colorectal cancer, we aimed to build a predictive model for recurrence after surgery. Using 80 samples as a training set, we examined gene expression by microarray and RT-PCR. We finally selected 8 genes whose expression differed significantly between patients who developed recurrence and who did not. We used these 8 genes for predictive model. The accuracy rate of prediction was 63% among 24 samples as a test set.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer2011
Author(s)
Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
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Journal Title
Int J Oncol
Volume: 38(1)
Pages: 201-207
Related Report
Peer Reviewed
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[Journal Article] Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis2011
Author(s)
Watanabe T, Kobunai T, Yamamoto Y, Ikeuchi H, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
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Journal Title
Clin Colorectal Cancer
Volume: 10(2)
Pages: 134-141
Related Report
Peer Reviewed
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[Journal Article] Gene expression of vascular endothelial growth factor a, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients2011
Author(s)
Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Shibuya H, Ikeuchi H
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Journal Title
Dis Colon Rectum
Volume: 54(8)
Pages: 1026-35
Related Report
Peer Reviewed
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[Journal Article] Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes2010
Author(s)
Watanabe T, Kobunai T, Yamamoto Y, Kanazawa T, Konishi T, Tanaka T, Matsuda K, Ishihara S, Nozawa K, Eshima K, Muto T, Nagawa H
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Journal Title
Eur J Cancer
Volume: 46(11)
Pages: 2119-26
Related Report
Peer Reviewed
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