• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prediction of high-risk stage II colorectal cancer by gene expression profile

Research Project

Project/Area Number 21591733
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTeikyo University

Principal Investigator

ISHIHARA Soichiro  帝京大学, 医学部, 講師 (00376443)

Co-Investigator(Kenkyū-buntansha) WATANABE Toshiaki  帝京大学, 医学部, 教授 (80210920)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords大腸癌 / ハイリスク / 術後補助化学療法 / DNAマイクロアレイ / 遺伝子発現
Research Abstract

Based on the gene expression of stage II colorectal cancer, we aimed to build a predictive model for recurrence after surgery. Using 80 samples as a training set, we examined gene expression by microarray and RT-PCR. We finally selected 8 genes whose expression differed significantly between patients who developed recurrence and who did not. We used these 8 genes for predictive model. The accuracy rate of prediction was 63% among 24 samples as a test set.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results)

  • [Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer2011

    • Author(s)
      Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
    • Journal Title

      Int J Oncol

      Volume: 38(1) Pages: 201-207

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis2011

    • Author(s)
      Watanabe T, Kobunai T, Yamamoto Y, Ikeuchi H, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
    • Journal Title

      Clin Colorectal Cancer

      Volume: 10(2) Pages: 134-141

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of vascular endothelial growth factor a, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients2011

    • Author(s)
      Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Shibuya H, Ikeuchi H
    • Journal Title

      Dis Colon Rectum

      Volume: 54(8) Pages: 1026-35

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential gene expression signatures between colorectal cancers with and without KRAS mutations : Crosstalk between the KRAS pathway and other signaling pathways2011

    • Author(s)
      Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Ikeuchi H, Eshima K
    • Journal Title

      Eur J Cancer

      Volume: 47(13) Pages: 1946-1954

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大腸癌研究会(JSCCR)大腸癌治療ガイドライン2010年版(Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer)2011

    • Author(s)
      Watanabe T, et al
    • Journal Title

      Clinical Colorectal Cancer

      Volume: 17 Issue: 1 Pages: 1

    • DOI

      10.1007/s10147-011-0315-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of vascular endothelial growth factor A, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients2011

    • Author(s)
      Watanabe T, et al
    • Journal Title

      Diseases of the Colon and Rectum

      Volume: 54 Issue: 8 Pages: 1026

    • DOI

      10.1097/dcr.0b013e31821c44af

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signalling pathways2011

    • Author(s)
      Watanabe T, et al
    • Journal Title

      European Journal of Cancer

      Volume: 47 Issue: 13 Pages: 1946

    • DOI

      10.1016/j.ejca.2011.03.029

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer.2011

    • Author(s)
      Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, et al.
    • Journal Title

      International Journal of Oncology

      Volume: 38(1) Pages: 201-207

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Significance of 18q Loss of Heterzygosity in Microsatellite-Stable Colorectal Cancer2010

    • Author(s)
      Watanabe T, Kobunai T, Yamamoto Y, Konishi T, Yano H, Iinuma H, Hayama T, Nozawa K, Ishihara S, Matsuda K
    • Journal Title

      J Clin Oncol

      Volume: 28(7)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes2010

    • Author(s)
      Watanabe T, Kobunai T, Yamamoto Y, Kanazawa T, Konishi T, Tanaka T, Matsuda K, Ishihara S, Nozawa K, Eshima K, Muto T, Nagawa H
    • Journal Title

      Eur J Cancer

      Volume: 46(11) Pages: 2119-26

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of response to preoperative radiotherapy, lymph node metastasis, and CEA level in patients undergoing total mesorectal excision of rectal cancer2010

    • Author(s)
      Ishihara S, Watanabe T, Kiyomatsu T, Yasuda K, Nagawa H
    • Journal Title

      Int J Colorectal Dis

      Volume: 25(12) Pages: 1417-1425

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerese chain reaction analysis of 10 genes.2010

    • Author(s)
      Watanabe T, Kobunai T, Yamamoto Y, Kanazawa T, Konishi T, Tanaka T, Matsuda K, Ishihara S, Nozawa K, et al.
    • Journal Title

      European Journal of Cancer

      Volume: 46(11) Pages: 2119-2126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of response to preoperative radiotherapy, lymph node metastasis, and CEA level in patients undergoing total mesorectal excision of rectal cancer.2010

    • Author(s)
      Ishihara S, Watanabe T, Kiyomatsu T, Yasuda K, Nagawa H.
    • Journal Title

      International journal of colorectal disease

      Volume: 25(12) Pages: 1417-1425

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Significance of 18q Loss of Heterzygosity in Microsatellite-Stable Colorectal Cancer.2010

    • Author(s)
      Watanabe T, Ishihara S, et al.
    • Journal Title

      Journal of Clinical Oncology 28(7)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray2009

    • Author(s)
      Watanabe T, Kobunai T, Tanaka T, Ishihara S, Matsuda K, Nagawa H
    • Journal Title

      Dis Colon Rectum

      Volume: 52(12) Pages: 1941-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression signature and the prediction of lymph node metastasisin colorectal cancer by DNA microarray.2009

    • Author(s)
      Watanabe T, Ishihara S, et al.
    • Journal Title

      Diseases of the Colon and Rectum 52(12)

      Pages: 1941-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi