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The effect of suppression of NF kB activity on the radio-sensitivity of colon cancer cells and on the prevention of intestinal damage.

Research Project

Project/Area Number 21591738
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHyogo Medical University

Principal Investigator

YOSHIDA Yasuhiko (2010-2011)  兵庫医科大学, 医学部, 研究生(研究員) (40434948)

王 孔志 (2009)  Hyogo College of Medicine, 医学部, 助教 (80340967)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Jiro  兵庫医科大学, 医学部, 教授 (90199373)
IIMURO Yuji  兵庫医科大学, 医学部, 教授 (30252018)
HIRANO Tadamichi  兵庫医科大学, 医学部, 講師 (90340968)
OKADA Toshihiro  兵庫医科大学, 医学部, 講師 (70351799)
UYAMA Naoki  兵庫医科大学, 医学部, 研究生(研究員) (70402873)
吉田 康彦  兵庫医科大学, 医学部, 助教 (40434948)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords放射性感受性 / 肝細胞増殖因子 / おとり型核酸 / 放射線障害 / 放躰性感受性 / 放射線感受性
Research Abstract

In a mouse model of radiation induced-chronic intestinal injury, fibrogenesis was seen in the submucosal layer. We investigated the effect of HGF administration and NF-kB decoy transfection on fibrogenesis of intestinal wall in a mouse model. HGF administration, but not NF-kB decoy transfection, inhibited the fibrogenesis in the intestinal wall. Next, we investigated the effect of low-dose HGF administration and NF-kB decoy transfection on proliferation ability of a cell line of human colon cancer. NF-kB decoy transfection, but not low-dose HGF administration, inhibited proliferation of cancer cells. Last, we investigated the relationship between NF-kB and EMT in cancer cells. Unfortunately, NF-kB transfection did not change the gene expression of EMT related molecules.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (15 results) Book (3 results)

  • [Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
    • Journal Title

      Laboratory Investigation

      Volume: 92(1) Issue: 1 Pages: 57-71

    • DOI

      10.1038/labinvest.2011.150

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells2011

    • Author(s)
      Hoshikawa Y, Kanki K, Ashla AA, Arakaki Y, Azumi J, Yasui T, Tezuka Y, Matsumi Y, Tsuchiya H, Kurimasa A, Hisatome I, Hirano T, Fujimoto J, Kagechika H, Shomori K, Ito H, Shiota G.
    • Journal Title

      Cancer Science

      Volume: 102(5) Issue: 5 Pages: 934-941

    • DOI

      10.1111/j.1349-7006.2011.01889.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis2011

    • Author(s)
      Seki E, Park E, Fujimoto J.
    • Journal Title

      Hepatology Research

      Volume: 41(7) Issue: 7 Pages: 597-610

    • DOI

      10.1111/j.1872-034x.2011.00822.x

    • NAID

      10031144129

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters2010

    • Author(s)
      Iimuro Y, Kashiwagi T, Yamanaka J, Hirano T, Saito S, Sugimoto T, Watanabe S, Kuroda N, Okada T, Asano Y, Uyama N, Fujimoto J.
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 17(5) Pages: 673-81

    • NAID

      10027663484

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20703846

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice2010

    • Author(s)
      Tsutsui H, Imamura M, Fujimoto J, Nakanishi K.
    • Journal Title

      Gastroenterol Res Pract

      Pages: 641865-641865

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20634907

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice2009

    • Author(s)
      Ishikawa T, Nakai N, Liu NN, Shiba K, Isozaki K, Matsuda I, Ito T, Fujimoto J, Hatakeyama K, Kanda T, Hirota S.
    • Journal Title

      Lab Invest

      Volume: 89(10) Pages: 1161-8

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/19636292

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] A novel small molecule inhibitor of FAK inhibits the ability of proliferation and invasion of human cholangiocarcinoma cell lines in vitro2011

    • Author(s)
      Uyama N, Iimuro Y, Kuroda N, Hirano T, Okada T, Asano Y, Suzumura K, Fujimoto J.
    • Organizer
      International Surgical Week 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel small molecule inhibitor of FAK inhibits the ability of proliferation and invasion of human cholangiocarcinoma cell lines in vitro2011

    • Author(s)
      Uyama N, Iimuro Y, Kuroda N, Hirano T, Okada T, Asano Y, Suzumura K, Fujimoto J
    • Organizer
      International Surgical Week ISW 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝内胆管癌組織におけるFAKの発現とその役割2011

    • Author(s)
      宇山直樹, 飯室勇二, 近藤祐一, 鈴村和大, 吉田康彦, 佐竹真, 麻野泰包, 岡田敏弘, 平野公通, 黒田暢一, 藤元治朗
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 肝癌外科切除における最終確認診断としての術中造影エコーの有用性2011

    • Author(s)
      飯室勇二, 近藤祐一, 宇多優吾, 鈴村和大, 吉田康彦, 宇山直樹, 麻野泰包, 岡田敏弘, 平野公通, 田中弘教, 飯島尋子, 西口修平, 藤元治朗
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of preoperative 3D hepatectomy simulation system for liver resection and transplantation : Application to various kind of liver resection procedure2011

    • Author(s)
      Fujimoto J, Iimuro Y, Yada A, Kondo Y, Saito S, Sueoka H, Ohashi K.
    • Organizer
      46th Annual Congress of the European Society for Surgical Research
    • Place of Presentation
      Aachen
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Fascin, an actin bundlling protein, can be a novel marker of human hepatic stellate cells and may regulate functions of HSCs through FAK-PI3K-AKT pathway2011

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Satake M, Okada T, Hirano T, Kuroda N, Fujimoto J.
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Fascin, an actin bundlling protein, can be a novel marker of human hepatic stellate cells and may regulate functions of Hscs through FAK-PI3 K-AKT pathway2011

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Satake M, Okada T, Hirano T, Kuroda N, Fujimoto J
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of unique liver regeneration in patients with giant liver cysts after fenestration of cysts without liver resection2010

    • Author(s)
      Iimuro Y, Okada T, Yada A, Kondo Y, Suzumura K, Yoshida Y, Uyama N, Fujimoto J.
    • Organizer
      The 61st Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞癌内線維化領域に存在する線維芽細胞の免疫組織学的検討2010

    • Author(s)
      宇山直樹, 飯室勇二, 中井紀博, 近藤祐一, 鈴村和大, 佐竹真, 吉田康彦, 杉本貴昭, 麻野泰包, 斉藤慎一, 王孔志, 岡田敏弘, 平野公通, 黒田暢一, 山中潤一, 藤元治朗
    • Organizer
      第14回日本肝臓学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 2年以上生存リンパ節転移陽性肝内胆管癌(ICC)切除症例の検討2010

    • Author(s)
      平野公通, 山中潤一, 麻野泰包, 飯室勇二, 黒田暢一, 岡田敏弘, 斉藤慎一, 杉本貴昭, 宇山直樹, 藤元治朗
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Application of computational portal flow dynamics simulation to liver regeneration analysis2009

    • Author(s)
      Iimuro Y, Uyama N, Sugimoto T, Saito S, Hirano T, Yamanaka J, Fujimoto J.
    • Organizer
      The 43rd World Congress of the International Society of Surgery
    • Place of Presentation
      Adelaide
    • Year and Date
      2009-09-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Heat shock protein 47 regulates expression of Collagen V and TIMP2 in pancreatic cancer cells2009

    • Author(s)
      Uyama N, Kuroda N, Ohashi K, Sugimoto T, Kondo Y, Suzumura K, Yoshida Y, Satake M, Asano Y, Saito S, Oh K, Okada T, Hirano T, Yamanaka J, Iimuro Y, Fujimoto J.
    • Organizer
      Digestive Disease Week and the 110th Annual Meeting of the AGA Institute
    • Place of Presentation
      Chicago
    • Year and Date
      2009-05-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞癌に対する分子治療の基礎的検討2009

    • Author(s)
      藤元治朗
    • Organizer
      (ワークショップ)第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝再生制御因子としての肝内門脈血流動態の解析と肝内メカニカルストレス受容体の検索2009

    • Author(s)
      飯室勇二, 宇山直樹, 斉藤慎一, 麻野泰包, 杉本貴昭, 岡田敏弘, 平野公通, 黒田暢一, 山中潤一, 藤元治朗
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞癌に対する遺伝子治療-臨床応用に向けての問題点2009

    • Author(s)
      平野公通, 山中潤一, 飯室勇二, 黒田暢一, 岡田敏弘, 斉藤慎一, 杉本貴昭, 麻野泰包, 吉田康彦, 鈴村和大, 藤元治朗
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-01
    • Related Report
      2011 Final Research Report
  • [Book] 消化器外科学レビュー2011-最新主要文献と解説-第1版(肝胆膵の画像診断)2011

    • Author(s)
      大橋浩一郎, 藤元治朗, 渡邊昌彦, 國土典宏, 土岐祐一郎
    • Publisher
      総合医学社
    • Related Report
      2011 Final Research Report
  • [Book] 総胆管輪状狭窄症(井廻道夫編)肝・胆道系症候群-その他の肝・胆道系疾患を含めて-2011

    • Author(s)
      飯室勇二
    • Publisher
      日本臨牀社
    • Related Report
      2011 Final Research Report
  • [Book] 疾病と検査2010

    • Author(s)
      岡田敏弘, 藤元治朗, 松田暉, 荻原俊男, 難波光義, 鈴木久美, 林直子
    • Publisher
      南江堂
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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