| Project/Area Number |
21591738
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
YOSHIDA Yasuhiko (2010-2011) 兵庫医科大学, 医学部, 研究生(研究員) (40434948)
王 孔志 (2009) Hyogo College of Medicine, 医学部, 助教 (80340967)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373)
IIMURO Yuji 兵庫医科大学, 医学部, 教授 (30252018)
HIRANO Tadamichi 兵庫医科大学, 医学部, 講師 (90340968)
OKADA Toshihiro 兵庫医科大学, 医学部, 講師 (70351799)
UYAMA Naoki 兵庫医科大学, 医学部, 研究生(研究員) (70402873)
吉田 康彦 兵庫医科大学, 医学部, 助教 (40434948)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射性感受性 / 肝細胞増殖因子 / おとり型核酸 / 放射線障害 / 放躰性感受性 / 放射線感受性 |
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| Research Abstract |
In a mouse model of radiation induced-chronic intestinal injury, fibrogenesis was seen in the submucosal layer. We investigated the effect of HGF administration and NF-kB decoy transfection on fibrogenesis of intestinal wall in a mouse model. HGF administration, but not NF-kB decoy transfection, inhibited the fibrogenesis in the intestinal wall. Next, we investigated the effect of low-dose HGF administration and NF-kB decoy transfection on proliferation ability of a cell line of human colon cancer. NF-kB decoy transfection, but not low-dose HGF administration, inhibited proliferation of cancer cells. Last, we investigated the relationship between NF-kB and EMT in cancer cells. Unfortunately, NF-kB transfection did not change the gene expression of EMT related molecules.
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