The functional analysis and treatment strategy of claudin-1 in a recurrence and metastasis of human colorectal cancer
| Project/Area Number |
21591740
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 大腸癌再発・転移 / Claudin-1 / 機能解析 / 大腸癌治療戦略 / 治療戦略 / claudin-1 |
|---|
| Research Abstract |
To investigate the potential involvement of claudin-1(CL-1) in the tumorigenesis of rectal cancer by analyzing the correlation between CL-1 expression, clinicopathological factors and prognosis. Rectal cancer tissue specimens from 306 patients were evaluated using immunohistochemical analysis for expression of CL-1 and correlated with clinicopathological factors. Loss of claudin-1 expression is a strong predictor of disease recurrence and poor patient survival in stage II and III rectal cancer.
The possible involvement of CL-1 was investigated in the tumorigenesis of UC-associated CRC. The immunostaining pattern of the high-grade dysplasia and UC-associated CRC for CL-1 showed much stronger and more diffuse staining in comparison to the normal or UC colonic mucosa. CL-1 plays a pivotal role in the regulation of cellular morphology and behavior in UC.
|
Report
(4 results)
Research Products
(76 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Claudin-1 Protein is a Major Factor Involved in the Tumorigenesis of Colorectal Cancer2009
Author(s)
Huo Q., Kinugasa T., Wang L., Huang J., Zhao J., Shibaguchi H., Kuroki Mo., Tanaka T., Yamashita Y., Nabeshima K., Iwasaki H. and Kuroki Ma
-
Journal Title
Anticancer Res
Volume: 29
Pages: 851-858
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
