| Project/Area Number |
21591742
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARUMI Shunji 弘前大学, 大学院・医学研究科, 准教授 (90250612)
TOYOKI Yoshikazu 弘前大学, 大学院・医学研究科, 講師 (70301025)
ISHIDO Keinosuke 弘前大学, 大学院・医学研究科, 助教 (00436023)
KUDO Daisuke 弘前大学, 医部附属病院, 助教 (00587024)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 大腸癌 / 転移性肝癌 / 化学療法 / 薬剤性肝障害 / トランスポーター / イリノテカン / 脂肪肝炎 / 類洞拡張 / 大腸癌肝転移 / 化学療法後肝障害 / アニオントランスポーター / 肝切除 |
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| Research Abstract |
Conversion h epatectomy is now accepted as a promising strategy against initially unresectable colorectal liver metastasis. In this project, we investigated the mechanisms of liver cell injury for the purpose of expanding the indication of conversion hepatectomy by pre venting chemotherapy induced liver damage. In clinical observation, we disclosed the histological pattern of liver injury according to chemotherapy regimen. In basic research, we developed a new animal model of irinotecan-induced chemotherapy-associated st eatohepatitis, and revealed molecular regulatory mechanisms in lipid metabolism and expression of organic anion transporters.
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