| Project/Area Number |
21591743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ODA Tatsuya University of Tsukuba, 大学院・人間総合科学研究科, 講師 (20282353)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Soichiro 筑波大学, 大学院・人間総合科学研究科, 講師 (40436275)
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| Co-Investigator(Renkei-kenkyūsha) |
KITA Eiji 筑波大学, 大学院・数理物質科学研究科, 教授 (80134203)
KANAMORI Toshiyuki 独立行政法人産業技術総合研究所, バイオニクス研究センターバイオナノマテリアルチーム, 主任研究員 (50356797)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝臓外科学 / がん / 磁性体 / ナノ粒子 / 電磁誘導加熱 |
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| Research Abstract |
For clinical application of induction heating cancer therapy, specific accumulation of magnetic nanoparticles to cancer tissue is a indispensable fundamental technique. Conventional approach, viz. tumor specific antibody conjugate nanoparticle, confer only 0.2mg/g tumor accumulation. Intending to precipitate more particles to tumor, we have tried to innovate multiple step administration of biotinaized and avidinaized magnetic nanoparticles alternateively. This approach, however, failed to accumulate nanoparticles to tumor, due to non-specific trap by Kpper cells in liver. When we tried alternative approach, i.e. decoration of nonparticle surface with original unique PEG, 0.58mg/g tumor accumulation have achieved.
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