| Project/Area Number |
21591744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
SHIMIZU Hiroaki 千葉大学, 大学院・医学研究院, 講師 (80272318)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
KIMURA Fumio 千葉大学, 大学院・医学研究院, 准教授 (70334208)
OHTSUKA Masayuki 千葉大学, 医学部附属病院, 講師 (90334185)
須田 浩介 千葉大学, 医学部・附属病院, 助教 (50400908)
三橋 登 千葉大学, フロンティアメディカル工学研究開発センター, 准教授 (80400985)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝再生 / 類洞内皮細胞 / 血管内皮前駆細胞 / 肝切除 |
|---|
| Research Abstract |
VEGF secreted by hepatocytes may play a key role in SEC proliferation, followed by increased Ang-1, presumably promoting sinusoidal maturation. Thereafter, Ang-2 mainly released from HSCs in the absence of VEGF may contribute to apoptosis of superfluous SECs for cessation of the regenerative process. In conclusion, Ang-Tie system, together with VEGF plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy
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