| Project/Area Number |
21591747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
ISAJI Shuji 三重大学, 大学院・医学系研究科, 教授 (70176121)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Masami 三重大学, 大学院・医学系研究科, 准教授 (90291418)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生体肝移植 / 過小グラフト / 脾臓 / 脾摘 / 肝再生 / 過少グラフト / 肝類洞内皮 / 門脈圧 / 炎症性サイトカイン / 肝虚血再潅流 / 免疫応答 |
|---|
| Research Abstract |
Small-for-size liver grafts are a serious obstacle for partial orthotopic liver transplantation. The results using a rat model suggest that a preservation solution containing APC is a potential novel and safe product for small-for-size liver transplantation, alleviating graft injury via anti-inflammatory and antiapoptotic effects and vasorelaxing conditions. Additionally, splenectomy before transplantation inhibited leukocyte infiltrations and pro-inflammatory cytokine synthesis which leads to hepatocellular apoptosis and impaired liver regeneration. Clinically, control of portal venous pressure immediately after living donor liver transplantation using small-for-size liver graft is very important, and preoperative assessment of the recipient's spleen volume and graft volume is very helpful to determine the necessity of splenectomy.
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