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CHALLNEGE TO OVERCOME LIVING DONOR LIVER TRANSPLANTATION USING SMALL-FOR-SIZE GRAFT

Research Project

Project/Area Number 21591747
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionMie University

Principal Investigator

ISAJI Shuji  三重大学, 大学院・医学系研究科, 教授 (70176121)

Co-Investigator(Kenkyū-buntansha) TABATA Masami  三重大学, 大学院・医学系研究科, 准教授 (90291418)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生体肝移植 / 過小グラフト / 脾臓 / 脾摘 / 肝再生 / 過少グラフト / 肝類洞内皮 / 門脈圧 / 炎症性サイトカイン / 肝虚血再潅流 / 免疫応答
Research Abstract

Small-for-size liver grafts are a serious obstacle for partial orthotopic liver transplantation. The results using a rat model suggest that a preservation solution containing APC is a potential novel and safe product for small-for-size liver transplantation, alleviating graft injury via anti-inflammatory and antiapoptotic effects and vasorelaxing conditions. Additionally, splenectomy before transplantation inhibited leukocyte infiltrations and pro-inflammatory cytokine synthesis which leads to hepatocellular apoptosis and impaired liver regeneration. Clinically, control of portal venous pressure immediately after living donor liver transplantation using small-for-size liver graft is very important, and preoperative assessment of the recipient's spleen volume and graft volume is very helpful to determine the necessity of splenectomy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Intracellular interferon-γstaining analysis of donor-specific T-cell responses in liver transplant recipients2012

    • Author(s)
      Okanami Y, Tsujimura K, Mizuno S, Tabata M, Isaji S, Akatsuka Y, Kuzushima K, Takahashi T, Uemoto S
    • Journal Title

      Transplant Proc

      Volume: 44(2) Pages: 548-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation for the patients with portal vein thrombosis : use of an interpositional venous graft passed posteriorly to the pancreatic parenchyma without using jump graft2012

    • Author(s)
      Mizuno S, Murata Y, Kuriyama N, Ohsawa I, Kishiwada M, Hamada T, Usui M, Sakurai H, Tabata M, Isaji S
    • Journal Title

      Transplant Proc

      Volume: 44(2) Pages: 356-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative liver dysfunction in living donors after left-sided graft hepatectomy : portal venous occlusion of the medial segment after lateral segmentectomy and hepatic venous congestion after left lobe hepatectomy2012

    • Author(s)
      Kumamoto K, Mizuno S, Kuriyama N, Ohsawa I, Kishiwada M, Hamada T, Usui M, Sakurai H, Tabata M, Isaji S
    • Journal Title

      Transplant Proc

      Volume: 44(2) Pages: 332-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donor age affects liver regeneration during early period in the graft liver and late period in the remnant liver after living donor liver transplantation2012

    • Author(s)
      Tanemura A, Mizuno S, Wada H, Yamada T, Nobori T, Isaji S
    • Journal Title

      World J Surg

      Volume: 36(5) Pages: 1102-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy2011

    • Author(s)
      Usui M, Kato H, Kuriyama N, Azumi Y, Kishiwada M, Mizuno S, Sakurai H, Tabata M, Hayashi T, Suzuki K, Isaji S
    • Journal Title

      Surg Today

      Volume: 41(2) Pages: 230-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients2011

    • Author(s)
      Muraki Y, Isaji S, et al
    • Journal Title

      Ann Transplant

      Volume: 16 Pages: 55-62

    • NAID

      120005228794

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lethal hepatic infarction following plasma exchange in living donor liver transplant patients2011

    • Author(s)
      Mizuno S, Isaji S, et al
    • Journal Title

      Transplant Int

      Volume: 24 Issue: 7 Pages: e57-e58

    • DOI

      10.1111/j.1432-2277.2011.01244.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring peripheral blood CD4+ adenosine triphosphate activity after living donor liver transplantation : impact of combination assaysof immune function and CYP3A5 genotype2011

    • Author(s)
      Mizuno S, Isaji S, et al
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 18 Issue: 2 Pages: 226-232

    • DOI

      10.1007/s00534-010-0335-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats.2010

    • Author(s)
      Kuriyama N, Isaji S, et al
    • Journal Title

      Liver Transplantation

      Volume: 16 Pages: 1-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective study on the outcome of patients with hepatocellular carcinoma registered for living donor liver transplantation : how long can they wait?2010

    • Author(s)
      Mizuno S, Isaji S, et al
    • Journal Title

      Transplantation

      Volume: 89 Pages: 650-654

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indocyanine green (ICG) fluorescence imaging-guided cholangiography for donor hepatectomy in living donor liver transplantation.2010

    • Author(s)
      Mizuno S, Isaji S
    • Journal Title

      American Journal of Transplantation

      Volume: 10 Pages: 2725-2726

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cytoprotective effect of addition of activated protein C into preservation solution on small-for-size grafts in rats2010

    • Author(s)
      Naohisa Kuriyama
    • Journal Title

      LIVER TRANSPLANTATION 16

      Pages: 1-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 移植後胆道狭窄に対する治療の長期成績胆管胆管吻合を施行した生体肝移植症例における術後胆道合併症の検討2011

    • Author(s)
      水野修吾,村田泰洋,熊本幸司,栗山直久,大澤一郎,岸和田昌之,濱田賢司,臼井正信,櫻井洋至,田端正巳,伊佐地秀司
    • Organizer
      日本移植学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体肝移植術後の門脈圧上昇には術前脾容量が関与する2011

    • Author(s)
      尭天一亨,水野修吾,信岡祐,栗山直久,大澤一郎,岸和田昌之,濱田賢司,臼井正信,櫻井洋至,田端正巳,伊佐地秀司
    • Organizer
      日本移植学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 生体肝移植術後血小板値はなぜ低下するのか? ADAMTS13の変動から見たグラフト肝微小循環障害と予後の観点から2011

    • Author(s)
      信岡祐,水野修吾,和田秀夫,大澤一郎,岸和田昌之,濱田賢司,臼井正信,櫻井洋至,田端正己,伊佐地秀司
    • Organizer
      日本肝胆膵外科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体肝移植術後免疫抑制療法におけるCD4陽性リンパ球ATP活性の有用性特にCYP3A5遺伝子多型との関連性について2010

    • Author(s)
      水野修吾,服部可奈,濱田賢司,大澤一郎,岸和田昌之,臼井正信,櫻井洋至,田端正己,伊佐地秀司
    • Organizer
      日本移植学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 脾臓は肝虚血再灌流障害後の免疫反応を調節する脾臓の新しい機能と肝臓外科における摘脾術の意義の再考2010

    • Author(s)
      加藤宏之,濱田賢司,村田泰洋,信岡祐,安積良紀,岸和田昌之,水野修吾,臼井正信,櫻井洋至,田端正己,伊佐地秀司
    • Organizer
      日本肝胆膵外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 脾臓は肝虚血再灌流障害後の免疫反応を調節する-脾臓の新しい機能と肝臓外科における摘脾術の意義の再考2010

    • Author(s)
      加藤宏之、伊佐地秀司
    • Organizer
      日本肝胆膵外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット過小グラフト肝移植における脾臓摘出術の細胞保護効果について2009

    • Author(s)
      栗山直久
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      副胃火国際会議場
    • Year and Date
      2009-04-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝虚血再還流障害モデルラットに対する組換えヒト可溶性トロンボモジュリンの保護効果2009

    • Author(s)
      岸和田昌之
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.medic.mie-u.ac.jp/hbpt/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.medic.mie-u.ac.jp/hbpt/HBP_and_Transplant_Surgery/gan_yi_zhi.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.me.com/shujiisaji1/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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