Cellular and molecular target therapy for hepatic ischemia-reperfusion injury
Project/Area Number |
21591748
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Hiroshima University |
Principal Investigator |
TASHIRO Hirotaka 広島大学, 大学院・医歯薬学総合研究科, 准教授 (90359894)
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Co-Investigator(Kenkyū-buntansha) |
KIMURA Yasuhiro 広島大学, 大学院・医歯薬学総合研究科, 准教授 (80314756)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 肝虚血再灌流障害 / 肝星細胞 / Rhoキナーゼ阻害剤 / リポソーム / ビタミンA / 肝虚血再潅流障害 / 分子・細胞標的治療 |
Research Abstract |
We have developed the vitamine A-coupled liposomes containing Rho kinase inhibitor to attenuate the hepatic ischemia-reperfusion injury in rat. First, GFP was specifically detected in the sinusoidal linings when the vitamine A-coupled liposome containing GFP was administered systemically. We have also confirmed that the liposomes have ameliorated the ischemia-reperfusion injuries at the dose of one-hundreds compared with alone Rho kinase inhibitor, with attenuating the side effects such as a hypotension
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Impact of pegylated-interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellularcar cinoma after curative hepatic resection2012
Author(s)
Tanimoto Y, Tashiro H, Aikata H, AmanoH, Oshita A, Kobayashi T, Kuroda K, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H.
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Journal Title
Ann Surg Oncol
Volume: 19
Pages: 418-425
Related Report
Peer Reviewed
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[Journal Article] Safety and Feasibility of Diet-Treated Donors With Steatotic Livers at the Initial Consultation for Living-Donor Liver Transplantation2012
Author(s)
Oshita A, Tashiro H, Amano H, Kobayashi T, Onoe T, Ide K, Takaki S, Takahashi S, Arihiro K, Chayama K, Ohdan H.
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Journal Title
Transplantation
Volume: (in press.)
Related Report
Peer Reviewed
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[Journal Article] Prognostic Significance of Antithrombin III Levels for Outcomes in Patients with Hepatocellular Carcinoma After Curative Hepatectomy2012
Author(s)
Iwako H, Tashiro H, Amano H, TanimotoY, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H.
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Journal Title
Ann Surg Oncol
Volume: (in press.)
Related Report
Peer Reviewed
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[Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection2012
Author(s)
Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
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Journal Title
Ann Surg Oncol
Volume: 19
Issue: 2
Pages: 418-425
DOI
Related Report
Peer Reviewed
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[Journal Article] IL28B SNP of donors and recipients can predict virological response to PE GIFN/RBV therapy in patients with recurrent hepatitis C after living donor liver transplantation2012
Author(s)
Kawaoka T, Takahashi S, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Aikata H, Ochi H, Onoe T, Tashiro H, Ohdan H, Chayama K
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Journal Title
J Gastroenterol Hepatol
Volume: (In press)
Issue: 9
Pages: 1467-1472
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment strategy for early hepatocellular carcinomas : Comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection2011
Author(s)
Tashiro H, Aikata H, Waki K, Amano H, Oshita H, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, AsaharaT, Ohdan H.
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Journal Title
J Surg Oncol
Volume: 104
Pages: 3-9
Related Report
Peer Reviewed
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[Journal Article] Therapeutic potential of propagated hepatocyte transplantation in liver failure2011
Author(s)
Amano H, Hino H, Tateno C, Emoto K, Imaoka Y, Yamasaki C, Itamoto T, Tashiro H, Asahara T, Ohdan H, Yoshizato K
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Journal Title
J Surg Res
Volume: 167
Issue: 1
Pages: e29-e37
DOI
Related Report
Peer Reviewed
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[Journal Article] Kinetics of cellular and humoral immunity in a successful case positive kidney transplantation : a case report2011
Author(s)
Tanimine N, Ide K, Yamashita M, Tanaka Y, Igarashi Y, Banshodani M, Tazawa H, Basnet NB, Doskali M, Onoe T, Tashiro H, Ohdan H
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Journal Title
Transplant Proc
Volume: 43
Issue: 6
Pages: 2411-2414
DOI
Related Report
Peer Reviewed
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[Journal Article] IL28B polymorphism may guide pegylated interferon plus ribavirin therapy even after curative treatment for hepatitis C virus-related hepatooellular carcinoma2011
Author(s)
Kawaoka T, Aikata H, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
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Journal Title
J Viral Hepat
Volume: 18
Issue: 10
Pages: e550-e560
DOI
Related Report
Peer Reviewed
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[Journal Article] Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery : Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining region2011
Author(s)
Kawaoka T, Aikata H, Miyaki D, Murakami E, Azakami T, Takaki S, Nagaoki Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Hiraga N, Miki D, TsugeM, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H, Chayama K
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Journal Title
Hepatol Res
Volume: 41
Issue: 11
Pages: 1126-1131
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report2011
Author(s)
Kawaoka T, Hiraga N, Takahashi S, Takaki S, Tsuge M, Nagaoki Y, Hashimoto Y, Katamura Y, Muki D, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Ochi H, Tashiro H, Ohdan H, Chayama K
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Journal Title
Intervirology (Elpub 25 Aug.)
Volume: (Epub)
Issue: 4
Pages: 306-310
DOI
Related Report
Peer Reviewed
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[Journal Article] A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava : report of a case2011
Author(s)
Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
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Journal Title
Surg Today (Epub 30 Nov.)
Volume: (Epub)
Issue: 5
Pages: 505-508
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Treatment strategy for early hepatocellular carcinomas : Comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection2011
Author(s)
Tashiro H, Aikata H, Waki K, Amano H, Oshita H, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T, Ohdan H.
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Journal Title
J Surg Oncol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Therapeutic potential of propagated hepatocyte transplantation in liver failure.2010
Author(s)
Amano H, Hino H, Tateno C, Emoto K, Imaoka Y, Yamasaki C, Itamoto T, Tashiro H, Asahara T, Ohdan H, Yoshizato K.
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Journal Title
J Surg Res
Volume: 167
Pages: 29-37
Related Report
Peer Reviewed
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[Journal Article] Suppression of hepatocellular carcinoma recurrence after rat liver trans plantation by FTY720, a sphingosine-1-phosphate analog2009
Author(s)
Ushitora Y, Tashiro H, Ogawa T, Tanimoto Y, Kuroda S, Kobayashi T, Miyata Y, Itamoto T, Asahara T, Ohdan H
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Journal Title
Transplantation 88
Pages: 980-986
Related Report
Peer Reviewed
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[Presentation] Child-PughB原発性肝細胞癌に対する肝切除・肝移植症例の検討2011
Author(s)
黒田慎太郎, 田代裕尊, 藤國宣明, 楠部潤子, 田澤宏文, 谷本新学, 小林剛, 大下彰彦, 天野尋暢, 番匠谷将孝, 井手健太郎, 尾上隆司, 大段秀樹
Organizer
第66回日本消化器外科学会総会
Place of Presentation
名古屋
Year and Date
2011-07-13
Related Report
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[Presentation] Child-Pugh B原発性肝細胞癌に対する肝切除・肝移植症例の検討2011
Author(s)
黒田慎太郎, 田代裕尊, 藤國宣明, 楠部潤子, 田澤宏文, 谷本新学, 小林剛, 大下彰彦, 天野尋暢, 番匠谷将孝, 井手健太郎, 尾上隆司, 大段秀樹
Organizer
第66回日本消化器外科学会総会
Place of Presentation
名古屋
Year and Date
2011-07-13
Related Report
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