Prediction of prognosis of hepatocellular carcinoma with use of measurement of methylated CCND2 gene in the blood
| Project/Area Number |
21591749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
IIZUKA Norio 山口大学, 医学部附属病院, 准教授 (80332807)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUHISA Yoshihiro 山口大学, 医学部附属病院, 医員 (30379961)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝癌 / 腫瘍検査学 / 肝臓外科 |
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| Research Abstract |
The purpose of this study is to develop a minimally invasive predictive system with use of methylated CCND2 gene in the serum responsible for outcome of patients with hepatocellular carcinoma(HCC).
(1) We determined several conditions for serum collection and DNA extraction.
(2) We established a quantitative methylation-specific PCR analysis for CCND2 gene in serum.
(3) We demonstrated that methylation levels of CCND2 gene in serum were associated with poor outcome of patents
We reported the relevant research in the form of 9 papers(total of IF=26. 6) and read 17 papers at academic meetings
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Report
(4 results)
Research Products
(35 results)
