Molecular mechanisms of hepatitis C reinfection in a transplanted liver

• Project/Area Number: 21591752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University (2010-2011); Department of Clinical Research, National Hospital Organization National Kyushu Cancer Center (2009)
• Principal Investigator: IKEGAMI Toru 九州大学, 大学病院, 助教 (80432938)
• Co-Investigator(Kenkyū-buntansha): TAKETOMI Akinobu 九州大学, 大学病院, 講師 (70363364) ; SUGIMACHI Keishi 九州大学, 大学病院, 特任助教 (90452763) ; 副島 雄二 九州大学, 大学病院, 助教 (30325526)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 移植再生医療 / ウイルス / 外科 / 臨床

Research Abstract

In 49 cases who underwent living donor liver transplantation for hepatitis C, mutations in the amino acids 70/91, ISDR, IRRDR, in addition of IL-28N single nuclear polymorphism were analyzed. It was drawn that the combination of viral, donor and recipient factors could forecast the interferon sensitivity in treating recurrent hepatitis C after living donor liver transplantation.

Research Products

• [Journal Article] Bacterial Sepsis after Living Donor Liver Transplantation (2012)
  • Author(s): Ikegami T, Shirabe K, Yoshiya S, Yoshizumi T, Ninomiya M, Uchiyama H, Soejima Y, Maehara Y
  • Journal Title: The Impact of Early Enteral Nutrition. J Am Coll Surg Volume: 214(3) Pages: 288-95
• [Journal Article] The impact of renal replacement therapy before or after living donor liver transplantation (2012)
  • Author(s): Ikegami T, Shirabe K, Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Harada N, Maehara Y
  • Journal Title: Clin Transplant Volume: 26 Pages: 143-8
• [Journal Article] Risk factors that increase mortality after living donor liver transplantation (2012)
  • Author(s): Yoshizumi T, Shirabe K, Taketomi A, Uchiyama H, Harada N, Ijichi H, Yoshimatsu M, Ikegami T, Soejima Y, Maehara Y
  • Journal Title: Transplantation Volume: 93 Pages: 93-8
• [Journal Article] Expanding the applications of microvascular surgical techniques to digestive surgeries : a technical review (2012)
  • Author(s): Uchiyama H, Shirabe K, Morita M, Kakeji Y, Taketomi A, Soejima Y, Yoshizumi T, Ikegami T, Harada N, Kayashima H, Morita K, Maehara Y
  • Journal Title: Surg Today Volume: 42 Pages: 111-20
  • NAID: 10030230572
• [Journal Article] Bacterial Sepsis after Living Donor Liver Transplantation : The Impact of Early Enteral Nutrition (2012)
  • Author(s): Ikegami T (1/8), et al
  • Journal Title: J Am Coll Surg Volume: 214 Pages: 288-95
  • Peer Reviewed
• [Journal Article] Expanding the applications of microvascular surgical techniques to digestive surgeries : a technical review (2012)
  • Author(s): Uchiyama H, Ikegami T (8/12), et al
  • Journal Title: Sure Today Volume: 42 Issue: 2 Pages: 111-20
  • DOI: 10.1007/s00595-011-0032-5
  • Peer Reviewed
• [Journal Article] De novo autoimmune hepatitis subsequent to switching from type 2b to type 2a alpha-pegylated interferon treatment for recurrent hepatitis C after liver transplantation (2011)
  • Author(s): Takeishi K, Shirabe K, Toshima T, Ikegami T, Morita K, Fukuhara T, Motomura T, Mano Y, Uchiyama H, Soejima Y, Taketomi A, Maehara Y
  • Journal Title: report of a case Volume: 41(7) Pages: 1016-9
• [Journal Article] Kinetics of Anti-Blood Type Isoagglutinin Titers and B Lymphocytes in ABO-Incompatible Living Donor Liver Transplantation With Rituximab and Plasma Exchange (2011)
  • Author(s): Uchiyama H, Mano Y, Taketomi A, Soejima Y, Yoshizumi T, Ikegami T, Shirabe K, Maehara Y
  • Journal Title: Transplantation Volume: 92 Pages: 1134-9
• [Journal Article] Minimal hilar dissection prevents biliary anastomotic stricture after living donor liver transplantation (2011)
  • Author(s): Taketomi A, Yoshizumi T, Uchiyama H, Kayashima H, Hashimoto N, Maehara Y
  • Journal Title: Transplantation Volume: 92 Pages: 1147-51
• [Journal Article] インターフェロンの上手な使い方 (2011)
  • Author(s): 武冨紹信, 本村貴志, 福原崇介, 池上徹, 吉住朋晴, 調憲, 前原喜彦
  • Journal Title: 肝移植後のHCV感染に対するPEG-IFN/Ribavirin療法 Volume: 63巻6号 Pages: 1158-1164
• [Journal Article] 前原喜彦肝癌治療のアルゴリズム (2011)
  • Author(s): 森田和豊, 調憲, 本村貴志, 間野洋平, 戸島剛男, 橋本直隆, 萱島寛人, 増田稔郎, 池上徹, 吉住朋晴, 武冨紹信, 池田哲夫
  • Journal Title: 外科治療 Volume: 105巻5号 Pages: 429-434
• [Journal Article] DonorとRecipientの宿主遺伝子背景からみ (2011)
  • Author(s): 本村貴志, 武冨紹信, 福原崇介, 池上徹, 吉住朋晴, 調憲, 前原喜彦
  • Journal Title: た再発HCVに対するIFN感受性予測 Volume: 63巻1号 Pages: 135-142
• [Journal Article] De novo autoimmune hepatitis subsequent to switching from type 2b to type 2a alpha-pegylated interferon treatment for recurent hepatitis C after liver transplantation : report of a case (2011)
  • Author(s): Takeishi K., et al
  • Journal Title: Surg Today Volume: 41 Issue: 7 Pages: 1016-9
  • DOI: 10.1007/s00595-010-4392-z
  • Peer Reviewed
• [Journal Article] インターフェロンの上手な使い方肝移植後のHCV感染に対するPEG-IFN/Ribavirin療法 (2011)
  • Author(s): 武冨紹信, 池上徹(4/7), 等
  • Journal Title: 肝・胆・膵 Volume: 63
• [Journal Article] DonorとRecipientの宿主遺伝子背景からみた再発HCVに対するIFN感受性予測 (2011)
  • Author(s): 本村貴志, 池上徹(4/8)), 等
  • Journal Title: 肝・胆・膵 Volume: 63 Pages: 135-142
• [Journal Article] 肝癌治療のアルゴリズム (2011)
  • Author(s): 森田和豊, 池上徹(8/12), 等
  • Journal Title: 外科治療 Volume: 105 Pages: 429-434
• [Journal Article] Evolving Strategies to Prevent Biliary Strictures after Living Donor Liver Transplantation (2010)
  • Author(s): Ikegami T, Soejima Y, Shirabe K, Taketomi A, Yoshizumi T, Uchiyama H, Fukuhara T, Ikeda T, Maehara Y
  • Journal Title: Transplant Proc Volume: 42(9) Pages: 3624-9
• [Journal Article] Mutations in hepatitis C virus genotype 1b and the sensitivity of interferon-ribavirin therapy after liver transplantation (2010)
  • Author(s): Fukuhara T, Taketomi A, Okano S, Ikegami T, Soejima Y, Shirabe K, Maehara Y
  • Journal Title: J Hepatol Volume: 52 Pages: 672-80
• [Journal Article] Evolving Strategies to Prevent Biliary Strictures after Living Donor Liver Transplantation Transplant Proc (2010)
  • Author(s): Ikegami T, Soejima Y, Shirabe K, Taketomi A, Yoshizumi T, Uchiyama H, Fukuhara T, Ikeda T, Maehara Y
  • Journal Title: Evolving Strategies to Prevent Biliary Strictures after Living Donor Liver Transplantation Volume: 42(9) Pages: 3624-9
• [Journal Article] Soejima Y, Shirabe K, Maehara Y. Improved Results of a Surgical Resection for the Recurrence of Hepatocellular Carcinoma After Living Donor Liver Transplantation (2010)
  • Author(s): Taketomi A, Fukuhara T, Morita K, Kayashima H, Ninomiya M, Yamashita Y, Ikegami T, Uchiyama H, Yoshizumi T
  • Journal Title: Ann Surg Oncol Volume: 17(9) Pages: 2283-9
• [Journal Article] Predictors of Extrahepatic Recurrence After Curative Hepatectomy for Hepatocellular Carcinoma (2010)
  • Author(s): Taketomi A, Toshima T, Kitagawa D, Motomura T, Takeishi K, Mano Y, Kayashima H, Sugimachi K, Aishima S, Yamashita Y, Ikegami T, Gion T, Uchiyama H, Soejima Y, Maeda T, Shirabe K, Maehara Y
  • Journal Title: Ann Surg Oncol Volume: 17(10) Pages: 2740-6
• [Journal Article] Use of recipient' s left hepatic artery for artery reconstruction in right lobe living donor liver transplantation with duct-to-duct anastomosis (2010)
  • Author(s): Uchiyama H, Ikegami T, Soejima Y, Ninomiya M, Kayashima H, Taketomi A, Shirabe K, Maehara Y
  • Journal Title: Transplantation Volume: 89 Pages: 1016-21
• [Journal Article] Evolving strategies to prevent biliary strictures after living donor liver transplantation. (2010)
  • Author(s): Ikegami T, et al.
  • Journal Title: Transplant Proc. Volume: 42 Pages: 3624-9
  • Peer Reviewed
• [Journal Article] Mutations in hepatitis C virus genotype 1b and the sensitivity of interferon-ribavirin therapy after liver transplantation. (2010)
  • Author(s): Fukuhara T, Ikegami T, et al.
  • Journal Title: J Hepatol. Volume: 52 Pages: 672-80
  • Peer Reviewed
• [Journal Article] Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesis. (2010)
  • Author(s): Fukuhara T, Ikegami T, et al.
  • Journal Title: Hepatol Res. Volume: 40 Pages: 171-8
  • Peer Reviewed
• [Journal Article] The benefits of interferon treatment in patients without sustained viral response after living donor liver transplantation for hepatitis C. (2010)
  • Author(s): Ikegami T, et al.
  • Journal Title: Transplant Proc. 41 Pages: 4246-52
  • Peer Reviewed
• [Journal Article] Mutations in hepatitis C virus genotype 1b and the sensitivity of interferon-ribavirin therapy after liver transplantation. (2010)
  • Author(s): Fukuhara T, Ikegami T, et al.
  • Journal Title: J Hepatol. 52 Pages: 672-80
  • Peer Reviewed
• [Journal Article] Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesis. (2010)
  • Author(s): Fukuhara T, Ikegami T, et al.
  • Journal Title: Hepatol Res. 40 Pages: 171-8
  • Peer Reviewed
• [Journal Article] De novo hepatocellular carcinoma in a liver graft with sustained hepatitis (2009)
  • Author(s): Morita K, Taketomi A, Soejima Y, Ikegami T, Fukuhara T, Iguchi T, Nagata S, Sugimachi K, Gion T, Maehara Y
  • Journal Title: De novo hepatocellular carcinoma in a liver graft with sustained hepatitis Volume: 15 Pages: 1412-6
• [Journal Article] C型肝炎患者の術前・術後管理 (2006)
  • Author(s): 池上徹、永田茂行、副島雄二、武冨紹信、祇園智信、杉町圭史、内山秀昭、吉住朋晴、原田昇、前原喜彦
  • Journal Title: 外科 Volume: 71巻4号 Pages: 399-406
• [Presentation] 宿主IL28B/ITPA遺伝子多型解析から見た移植後再発HCVに対する治療戦略 (2011)
  • Author(s): 本村貴志,武冨紹信,福原崇介,吉屋匠平,武藤純,的野る美,間野洋平,戸島剛男,森田和豊,萱島寛人,池上徹,吉住朋晴,調憲,前原喜彦
  • Organizer: 第19回日本消化器関連学会週間
  • Place of Presentation: 福岡
• [Presentation] 生体肝移植後の肝癌再発予防を目指したIL12/DC併用Neoadjuvant immunotherapyの展開 (2011)
  • Author(s): 萱島寛人,戸島剛男,岡野慎士,吉屋匠平,武藤純,的野る美,本村貴志,間野洋平,森田和豊,福原崇介,池上徹,吉住朋晴,武冨紹信,調憲,前原喜彦
  • Organizer: 第49回日本癌治療学会総会
  • Place of Presentation: 名古屋
• [Presentation] 肝・胆肝細胞癌に対する生体肝移植後の予後因子としてのmicroRNA発現の意義 (2011)
  • Author(s): 森田和豊,調憲,武冨紹信,吉屋匠平,武藤純,的野る美,本村貴志,間野洋平,戸島剛男,橋本直隆,萱島寛人,増田稔郎,池上徹,吉住朋晴,前原喜彦
  • Organizer: 第49回日本癌治療学会
  • Place of Presentation: 名古屋
• [Presentation] 生体肝移植後の肝癌再発予防を目指したIL12/DC併用Neoadjuvant immunoth erapyの展開 (2011)
  • Author(s): 萱島寛人, 池上徹(10/15), 等
  • Organizer: 第49回日本癌治療学会総会
  • Place of Presentation: 名古屋
• [Presentation] 血液型不適合肝移植における新しい免疫抑制プロトコールの有用性 (2010)
  • Author(s): 池上徹,副島雄二,調憲,武冨紹信,内山秀昭,吉住朋晴,二宮瑞樹,萱島寛人,森田和豊,武石一樹,前原喜彦
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] グラフト動注・門注療法を用いない血液型不適合肝移植 (2010)
  • Author(s): 池上徹
  • Organizer: 第110回 日本外科学会
  • Place of Presentation: 名古屋
• [Presentation] C型肝炎における肝組織中のmicroRNA-122発現の意義 (2009)
  • Author(s): 森田和豊,武冨紹信,梅田健二,井口友宏,永田茂行,杉町圭史,池上徹,祇園智信,副島雄二,前原喜彦
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] 肝移植後再発HCVに対するIFN治療におけるウイルスRNA変異による効果予測 (2009)
  • Author(s): 福原崇介,武冨紹信,副島雄二,森田和豊,植田茂,永田茂行,杉町圭史,池上徹,祇園智信,前原喜彦
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] HCV陽性例に対する生体肝移植後のステロイド使用法 (2009)
  • Author(s): 吉住朋晴,武冨紹信,副島雄二,原田昇,山下洋市,杉町圭史,丸山晴司,池上徹,永田茂行,前原喜彦
  • Organizer: 第29回日本移植学会
  • Place of Presentation: 仙台
• [Presentation] C型肝炎陽性肝細胞癌術後における初回IFN治療の有効性 (2009)
  • Author(s): 戸島剛男,武冨紹信,武石一樹,梅田健二,福原崇介,森田和豊,植田茂,井口友宏,實藤健作,永田茂行,杉町圭史,池上徹,祇園智信,副島雄二,前原喜彦
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡
• [Presentation] Elasticity Imagingによる新規低侵襲な肝線維化測定法の検討 (2009)
  • Author(s): 戸島剛男,武冨紹信,武石一樹,永田茂行,杉町圭史,池上徹,祇園智信,副島雄二,前原喜彦
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] 肝移植後再発HCVに対するIFN治療におけるウイルスRNA変異による効果予測 (2009)
  • Author(s): 原崇介、池上徹, 等
  • Organizer: 日本消化器外科学会
  • Place of Presentation: 大阪
• [Book] ABO血液型不適合移植の新戦略2010 (2010)
  • Author(s): 池上徹
  • Total Pages: 93
  • Publisher: 門脈・動脈注入療法を用いない新しい血液型不適合肝移植
• [Book] C型肝炎移植患者の術前・術後管理、外科 (2009)
  • Author(s): 池上徹
  • Total Pages: 7
  • Publisher: 南江堂