Significance of serum bile acid level to predict the effective functional hypertrophy of the nonembolized liver after portal vein embolization

• Project/Area Number: 21591757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: BEPPU Toru 熊本大学, 医学部附属病院, 准教授 (70301372)
• Co-Investigator(Kenkyū-buntansha): HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900) ; BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 増殖因子 / 肝再生 / 肝細胞増殖因子(HGF) / 肝萎縮 / 胆汁酸 / 門脈塞栓術 / 肝切除 / 肝切除術 / 肝容積 / 胆汁外瘻

Research Abstract

The clinical association between serum bile acid level changes and liver hypertrophy in portal vein embolization(PVE) is unknown. We clarified that PVE increases the serum bile acid level in patients with effective liver hypertrophy and the increase on day 3 is a useful predictor of effective hypertrophy(r=0. 613、P=0. 002). Serum bile acid levels were significantly higher in non-external bile drainage group and the regenerated liver volume was significantly greater(129ml vs. 39ml, P<0. 05). Besides, serum bile acid level is a useful predictor of liver regeneration.

Research Products

• [Journal Article] Portal vein embolization can prevent intrahepatic metastases to non-embolized liver (2012)
  • Author(s): Okabe K, Beppu T, Masuda T, Hayashi H, Okabe H, Komori H, Horino K, Sugiyama S, Ishiko T, Takamori H, Yamanaka T, Baba H
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 538-41
  • Peer Reviewed
• [Journal Article] Liver hanging maneuver decrease blood loss and operative time in a right-side hepatectomy (2012)
  • Author(s): Beppu T
  • Journal Title: Hepato-Gastroenterol Volume: 59 Pages: 542-545
  • NAID: 120005373806
  • Peer Reviewed
• [Journal Article] Fused 99m-Tc-GSA SPECT/CT imaging for the preoperative evaluation of postoperative liver function : can the liver uptake index predict postoperative hepatic functional reserve? (2012)
  • Author(s): Yoshida M
  • Journal Title: Jpn J Radiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Liver Functional Volumetry for Portal Vein Embolization Using a Newly-Developed 99mTc-Galactosyl Human Serum Albumin Scintigraphy SPECT-Computed Tomography Fusion System (2011)
  • Author(s): Beppu T, Hayashi H, Okabe H, Masuda T, Mima K, Sugiyama S, Horino K, Otao R, Chikamoto A, Doi K, Ishiko T, Takamori H, Yoshida M, Shiraishi S, Yamashita Y, Baba H
  • Journal Title: J Gastroenterol Volume: 46(7) Pages: 938-43
  • NAID: 10029313401
  • Peer Reviewed
• [Journal Article] Preoperative portal vein embolization(PVE) for patients with hepatocellular carcinoma can improve resectability and may improve disease-free survival (2011)
  • Author(s): Okabe H, Beppu T, Ishiko T, Masuda T, Hasyashi H, Otao R, Hasta H, Okabe K, Sugiyama S, Baba H
  • Journal Title: J Surg Oncol Volume: 104(6) Pages: 641-6
  • Peer Reviewed
• [Journal Article] Liver Functional Volumetry for Portal Vein Embolization Using a Newly-Developed 99mTc-Galactosyl Human Serum Albumin Scintigraphy SPE CT-Computed Tomography Fusion System (2011)
  • Author(s): Beppu T
  • Journal Title: J Gastroenterol Volume: 46 Pages: 938-943
  • NAID: 10029313401
  • Peer Reviewed
• [Journal Article] Preoperative portal vein embolization (PVE) for patients with hepatocellular carcinoma can improve resectability and may improve disease-free survival (2011)
  • Author(s): Okabe H
  • Journal Title: J Surg Oncol Volume: 104 Pages: 641-646
  • Peer Reviewed
• [Journal Article] A new approach to percutaneous transhepatic portal embolization using ethanolamine oleate iopamidol (2010)
  • Author(s): Beppu T, Iwatsuki M, Okabe H, Okabe K, Masuda T, Hayashi H, Sugiyama S, Horino K, Komori H, Hayashi N, Takamori H, Ishiko T, Baba H
  • Journal Title: J Gastroenterol Volume: 45 Pages: 211-217
  • NAID: 10027214645
  • Peer Reviewed
• [Journal Article] Serum HGF and TGF-b1 levels after right portal vein embolization (2010)
  • Author(s): Hayashi H, Beppu T, Sugita H, Horino K, Masuda T, Okabe H, Takamori H, Baba H
  • Journal Title: Hepatol Res Volume: 40 Pages: 311-317
  • Peer Reviewed
• [Journal Article] アシアロSPECT/CT融合画像による分肝機能評価 (2010)
  • Author(s): 別府透、林洋光、岡部弘尚、増田稔郎、太田尾龍、近本亮、石河隆敏、高森啓史、馬場秀夫白石慎哉、吉田守克、山下康行
  • Journal Title: 消化器内科 Volume: 50 Pages: 443-446
• [Journal Article] Serum HGF and TGF-β1 levels after right portal vein embolization. (2010)
  • Author(s): Beppu T
  • Journal Title: Hepatol Res40 Volume: 4 Pages: 311-317
  • NAID: 10027407888
  • Peer Reviewed
• [Journal Article] A new approach to percutaneous transhepatic portal embolization using ethanolamine oleate iopamidol (2010)
  • Author(s): Beppu T
  • Journal Title: J Gastroenerol 2010 45 Pages: 211-217
  • NAID: 10027214645
  • Peer Reviewed
• [Journal Article] Increase in the serum bile acid level predicts the effective hypertrophy of the nonembolized hepatic lobe after right portal vein embolization (2009)
  • Author(s): Hayashi H, Beppu T, Sugita H, Horino K, Komori H, Masuda T, Okabe H, Takamori H, Baba H
  • Journal Title: World J Surg Volume: 33 Pages: 1933-40
  • Peer Reviewed
• [Journal Article] Increase in the serum bile acid level predicts the effective hypertrophy of the nonembolized hepatic lobe after right portal vein embolization (2009)
  • Author(s): Hayashi H
  • Journal Title: World J Surg 33 Pages: 33-40
  • Peer Reviewed
• [Presentation] Preoperative portal vein embolization(PVE) can improve disease-free survival for patients with hepatocellular carcinoma (2011)
  • Author(s): Toru Beppu, Hideo Baba, et al.
  • Organizer: International Surgical Week 2011
  • Place of Presentation: Pacifico Yokohama, Japan
  • Year and Date: 2011-08-31
• [Presentation] 術前肝予備能評価の再考アシアロSPECT CT-fusionによる分肝機能評価門脈塞栓術と肝切除例における有用性 (2011)
  • Author(s): 増田稔郎
  • Organizer: 66回日本消化器外科学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-07-14
• [Presentation] 高ビリルビンを呈する肝細胞癌に対する肝切除の安全性と予後 (2011)
  • Author(s): 増田稔郎
  • Organizer: 23回日本肝胆膵外科学会
  • Place of Presentation: 東京京王プラザホテル
  • Year and Date: 2011-06-10
• [Presentation] 肝切除後の肝再生予測因子としての血清胆汁酸測定の意義 (2010)
  • Author(s): 太田尾龍、別府透、馬場秀夫, 他
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 海峡メッセ下関、下関市民会館(山口)
  • Year and Date: 2010-07-14
• [Presentation] 肝切除後の肝再生予測因子としての血清胆汁酸測定の意義 (2010)
  • Author(s): 太田尾龍、別府透
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 海峡メッセ下関、下関市民会館(福岡 下関)
  • Year and Date: 2010-07-14
• [Presentation] 門脈塞栓術前後における血清HGF, TGF-beta1の推移の臨床的意義 (2009)
  • Author(s): 林洋光、別府透、馬場秀夫, 他
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪,大阪国際会議場
  • Year and Date: 2009-07-17
• [Presentation] 門脈塞栓術前後における血清HGF, TGF-beta 1の推移の臨床的意義 (2009)
  • Author(s): 林洋光
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪 大阪国際会議場
  • Year and Date: 2009-07-17
• [Presentation] 右門脈塞栓術後の血清胆汁酸濃度のモニタリングは左葉の肝再生の予測に有用である (2009)
  • Author(s): 林洋光、別府透、馬場秀夫, 他
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 兵庫神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 右門脈塞栓術後の血清胆汁酸濃度のモニタリングは左葉の肝再生の予測に有用である (2009)
  • Author(s): 林洋光
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 兵庫 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] 肝切除後における胆汁外瘻化が肝再生を阻害する (2009)
  • Author(s): 太田尾龍、別府透、馬場秀夫, 他
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡、福岡国際会議場
  • Year and Date: 2009-04-04
• [Presentation] 肝切除後における胆汁外瘻化が肝再生を阻害する (2009)
  • Author(s): 太田尾龍
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2009-04-04