Significance of serum bile acid level to predict the effective functional hypertrophy of the nonembolized liver after portal vein embolization
| Project/Area Number |
21591757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
BEPPU Toru 熊本大学, 医学部附属病院, 准教授 (70301372)
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| Co-Investigator(Kenkyū-buntansha) |
HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 増殖因子 / 肝再生 / 肝細胞増殖因子(HGF) / 肝萎縮 / 胆汁酸 / 門脈塞栓術 / 肝切除 / 肝切除術 / 肝容積 / 胆汁外瘻 |
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| Research Abstract |
The clinical association between serum bile acid level changes and liver hypertrophy in portal vein embolization(PVE) is unknown. We clarified that PVE increases the serum bile acid level in patients with effective liver hypertrophy and the increase on day 3 is a useful predictor of effective hypertrophy(r=0. 613、P=0. 002). Serum bile acid levels were significantly higher in non-external bile drainage group and the regenerated liver volume was significantly greater(129ml vs. 39ml, P<0. 05). Besides, serum bile acid level is a useful predictor of liver regeneration.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Portal vein embolization can prevent intrahepatic metastases to non-embolized liver2012
Author(s)
Okabe K, Beppu T, Masuda T, Hayashi H, Okabe H, Komori H, Horino K, Sugiyama S, Ishiko T, Takamori H, Yamanaka T, Baba H
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Journal Title
Hepato-Gastroenterol
Volume: 59
Pages: 538-41
Related Report
Peer Reviewed
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[Journal Article] Liver Functional Volumetry for Portal Vein Embolization Using a Newly-Developed 99mTc-Galactosyl Human Serum Albumin Scintigraphy SPECT-Computed Tomography Fusion System2011
Author(s)
Beppu T, Hayashi H, Okabe H, Masuda T, Mima K, Sugiyama S, Horino K, Otao R, Chikamoto A, Doi K, Ishiko T, Takamori H, Yoshida M, Shiraishi S, Yamashita Y, Baba H
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Journal Title
J Gastroenterol
Volume: 46(7)
Pages: 938-43
NAID
Related Report
Peer Reviewed
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[Journal Article] A new approach to percutaneous transhepatic portal embolization using ethanolamine oleate iopamidol2010
Author(s)
Beppu T, Iwatsuki M, Okabe H, Okabe K, Masuda T, Hayashi H, Sugiyama S, Horino K, Komori H, Hayashi N, Takamori H, Ishiko T, Baba H
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Journal Title
J Gastroenterol
Volume: 45
Pages: 211-217
NAID
Related Report
Peer Reviewed
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