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Liver repair and reconstitution of the hepatic sinusoids after acute liver injury

Research Project

Project/Area Number 21591761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKitasato University

Principal Investigator

ITOH Yoshiya  北里大学, 医学部, 非常勤講師 (40203187)

Co-Investigator(Kenkyū-buntansha) MAJIMA Masataka  北里大学, 医学部, 教授 (70181641)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肝再生 / VEGF / マクロファージ / アセトアミノフェン / 肝類洞 / 肝微小血管 / 類洞
Research Abstract

The failure of liver to regenerate is considered a critical contributing factor in liver dysfunction and liver failure after chemical, liver surgery, and inflammation. Hepatic tissue repair, including the reconstitution of hepatic microvasculature, plays a critical role in determining the final outcome of acutely injured liver. The present study was conducted to examine whether VEGF, a well-known angiogenic growth factor, and its receptor, VEGFR1, are involved in liver repair and regeneration. In the model of acute liver injury elicited by acetaminophen(APAP) and hepatic ischemia/reperfusion, VEGFR1 signaling plays an important role in liver repair and sinusoidal restoration after APAP hepatotoxicity and hepatic ischemia/reperfusion through the recruitment of macrophages expressing VEGFR1.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 9 results) Presentation (7 results)

  • [Journal Article] Thromboxane A_2 receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells2012

    • Author(s)
      Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M
    • Journal Title

      Cancer Sci

      Volume: 103(4) Issue: 4 Pages: 700-7

    • DOI

      10.1111/j.1349-7006.2012.02200.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment2012

    • Author(s)
      Minamino T, Ito Y, et al
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 259 Pages: 104-114

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity2011

    • Author(s)
      T Kato, Y Ito, H Kanako, T Suzuki, T Hideaki, T Minamino, S Kato, H Sakagami, M Shibuya, M Majima
    • Journal Title

      Toxicol Sci

      Volume: 120(3) Pages: 218-228

    • Related Report
      2011 Final Research Report
  • [Journal Article] Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice2011

    • Author(s)
      Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 300(2)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation2011

    • Author(s)
      Hosono K, Majima M, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Pages: 1049-1058

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor receptor-1 signaling facilitates liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity2011

    • Author(s)
      Kato H, Ito Y, et al.
    • Journal Title

      Toxicol Sci

      Volume: 120 Pages: 218-229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice2011

    • Author(s)
      Mishima T, Ito Y, et al.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Erythropoietin on Angiogenesis With the Increased Adhesion of Platelets to the Microvessels in the Hind-Limb Ischemia Model in Mice2010

    • Author(s)
      Kato S, Amano H, Ito Y, Eshima K, Aoyama N, Tamaki H, Sakagami H, Satoh Y, Izumi T, Majima M.
    • Journal Title

      J Pharmacol Sci

      Volume: 112(2) Pages: 167-75

    • NAID

      10029888784

    • Related Report
      2011 Final Research Report
  • [Journal Article] COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems2010

    • Author(s)
      Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
    • Journal Title

      Am J Pathol

      Volume: 176(3) Pages: 1469-83

    • Related Report
      2011 Final Research Report
  • [Journal Article] m-PGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice2010

    • Author(s)
      Kamata H, Ito Y, et al.
    • Journal Title

      Biomed Pharmacother

      Volume: 64 Pages: 409-416

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived EP-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth2009

    • Author(s)
      Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 382(4) Pages: 720-725

    • Related Report
      2011 Final Research Report
  • [Journal Article] Bone marrow-derived EP-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth.2009

    • Author(s)
      Ogawa Y, Ito Y, et al.
    • Journal Title

      Biochem Biophys Res Commun. 382

      Pages: 720-725

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel therapeutic strategy for liver sinusoidal obstruction syndrome.2009

    • Author(s)
      Ito Y.
    • Journal Title

      J Gastroenterol Hepatol. 24

      Pages: 933-934

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of a Prostaglandin E type Receptor, EP3, in up-regulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis.2009

    • Author(s)
      Amano H, Ito Y, et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 2318-2324

    • NAID

      10027198074

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of VEGFR1 signaling in liver injury and repair following hepatic ischemia/reperfusion injury in mice2012

    • Author(s)
      Ohkubo H, Ito Y, Minamino T, Hosono K, Watanabe M, Majima M.
    • Organizer
      第37回日本微小循環学会
    • Place of Presentation
      盛岡、岩手
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of VEGFR1 signaling in liver injury and repair following hepatic ischemia/reperfusion injury in mice2012

    • Author(s)
      大久保、伊藤, ら
    • Organizer
      第37回日本微小循環学会
    • Place of Presentation
      盛岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] アセトアミノフェン誘発性肝障害後の肝修復における血管内皮増殖因子1型受容体の役割2011

    • Author(s)
      加藤哲希、伊藤義也、鈴木立紀、細野加奈子、南野勉、馬嶋正隆
    • Organizer
      第32回日本炎症再生医学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Vascular endothelial growth factor receptor-1 tyrosine kinase signaling facilitates hepatic repair and regeneration after acetaminophen-induced liver injury2010

    • Author(s)
      Yoshiya Ito, Tetsuki Kato, Tsutomu Minamino, Kanako Hosono, Masahiko Watanabe, Masataka Majima
    • Organizer
      15th International Symposium on Cells of the Hepatic Sinusoid
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] アセトアミノフェン誘発性肝障害におけるVEGF受容体シグナリングの役割2010

    • Author(s)
      加藤哲希、伊藤義也、細野加奈子、鈴木達紀、馬嶋正隆
    • Organizer
      第37回日本トキシコロジー学会学術年会
    • Place of Presentation
      沖縄
    • Related Report
      2011 Final Research Report
  • [Presentation] Vascular endothelial growth factor receptor-1 tyrosine kinase signaling facilitates hepaitc repair and regeneration after acetaminophen-induced liver injury2010

    • Author(s)
      Ito Y, et al.
    • Organizer
      International Symposium on Cells of Hepatic Sinusoid
    • Place of Presentation
      Pasedena, Calfornia, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] エンドトキシン血症における肝微小循環障害の成立機序とその病態生理学的意義2009

    • Author(s)
      伊藤義也、渡邊昌彦、馬嶋正隆
    • Organizer
      第24回日本Shock学会総会
    • Place of Presentation
      金沢
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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