Liver repair and reconstitution of the hepatic sinusoids after acute liver injury
| Project/Area Number |
21591761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
ITOH Yoshiya 北里大学, 医学部, 非常勤講師 (40203187)
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| Co-Investigator(Kenkyū-buntansha) |
MAJIMA Masataka 北里大学, 医学部, 教授 (70181641)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肝再生 / VEGF / マクロファージ / アセトアミノフェン / 肝類洞 / 肝微小血管 / 類洞 |
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| Research Abstract |
The failure of liver to regenerate is considered a critical contributing factor in liver dysfunction and liver failure after chemical, liver surgery, and inflammation. Hepatic tissue repair, including the reconstitution of hepatic microvasculature, plays a critical role in determining the final outcome of acutely injured liver. The present study was conducted to examine whether VEGF, a well-known angiogenic growth factor, and its receptor, VEGFR1, are involved in liver repair and regeneration. In the model of acute liver injury elicited by acetaminophen(APAP) and hepatic ischemia/reperfusion, VEGFR1 signaling plays an important role in liver repair and sinusoidal restoration after APAP hepatotoxicity and hepatic ischemia/reperfusion through the recruitment of macrophages expressing VEGFR1.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Thromboxane A_2 receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells2012
Author(s)
Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M
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Journal Title
Cancer Sci
Volume: 103(4)
Issue: 4
Pages: 700-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice2011
Author(s)
Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M.
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 300(2)
Related Report
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[Journal Article] COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems2010
Author(s)
Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
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Journal Title
Am J Pathol
Volume: 176(3)
Pages: 1469-83
Related Report
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[Journal Article] Bone marrow-derived EP-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth2009
Author(s)
Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
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Journal Title
Biochem Biophys Res Commun
Volume: 382(4)
Pages: 720-725
Related Report
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