| Project/Area Number |
21591765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UYAMA Naoki 兵庫医科大学, 医学部, 研究生(研究員) (70402873)
SATAKE Makoto 兵庫医科大学, 医学部, 助教 (70399153)
IIMURO Yuuji 兵庫医科大学, 医学部, 教授 (30252018)
FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肝臓外科学 / CCC / ケモカイン / 分子治療 / 新生血管抑制 / アンタゴニスト |
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| Research Abstract |
In the present study, we investigated the role of CXCR2 in intrahepatic cholangiocellular carcinoma(ICC). First, expression of CXCR2 is estimated by immunohistochemical staining in ICC using thirty ICC human specimens. Next, the role of CXCR2 was estimated in vitro by proliferation assay, migration assay, or invasion assay. In vivo effect was also estimated using xenograft mice model. As a result, blockage of CXCR2 significantly inhibited proliferation, migration, and invasion of ICC in vitro. Tumor growth of xenograft mice model was also inhibited by CXCR2 antagonist. Our results suggested that CXCR2 act crucial role in the development of ICC. Blockage of CXCR2 may be a promising therapeutic approach for ICC.
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