| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To clarify the resistant mechanism of gemcitabine(GEM), which is a standard agent for pancreatic cancer, a combination of targeted proteomic (LC-MS/MS)and metabolomic analyses were applied. The Attenuation of GEM phosphorylation by suppression of deoxycitidine kinase (dCK)was the most important mechanism for GEM resistance by using acquired resistant model and comparison of tissue expression profile and survival.
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