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Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma

Research Project

Project/Area Number 21591768
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNiigata University

Principal Investigator

WAKAI Toshifumi  新潟大学, 医歯学総合病院, 講師 (50372470)

Co-Investigator(Kenkyū-buntansha) SHIRAI Yoshio  新潟大学, 医歯学系, 准教授 (50216173)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胆道外科学 / 胆管癌 / 胆管切離断端 / p53-binding protein 1 / DNA損傷修復応答 / 上皮内癌 / アポトーシス / 53-binding protein 1
Research Abstract

This study aimed to clarify the early DNA damage response mediated by 53BP1 in tumor specimens of ductal resection margins and to elucidate its predictive value for clinically evident local recurrence at ductal stumps in 110 patients undergoing resection for extrahepatic cholangiocarcinoma. Ductal margin status was the only independent risk factor for local recurrence(P=0. 001). The cumulative probability of local recurrence at 5 years was 10%, 40%, and 100% in patients with negative ductal margins, positive with carcinoma in situ, and positive with invasive carcinoma, respectively(P<0. 001). Of the 14 tumor specimens of carcinoma in situ, 10 showed diffuse localization of 53BP1 in nuclei(53BP1 inactivation) and 4 showed discrete nuclear foci of 53BP1(53BP1 activation). Apoptotic index was markedly decreased in tumor specimens with 53BP1 inactivation compared to those with 53BP1 activation(median index, 0% vs. 22%; P<0. 001). Among 14 patients with residual carcinoma in situ, the cumulative probability of local recurrence was significantly higher in patients with 53BP1 inactivation than in patients with 53BP1 activation(60% vs. 0% at 5 years ; P=0. 020). In conclusion, after resection for extrahepatic cholangiocarcinoma, clinically evident local recurrence at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results)

  • [Journal Article] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma2011

    • Author(s)
      Wakai T, Shirai Y, Sakata J, Korita PV, Matsuda Y, Takamura M, Ohashi R, Nagahashi M, Ajioka Y, Hatakeyama K
    • Journal Title

      Int J Oncol

      Volume: 38(5) Pages: 1227-1236

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma2011

    • Author(s)
      若井俊文、松田康伸, 他8名
    • Journal Title

      Int J Oncol

      Volume: 38 Issue: 5 Pages: 1227-1236

    • DOI

      10.3892/ijo.2011.959

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胆管癌根治切除後の胆管切離断端に遺残した上皮内癌における早期DNA損傷修復応答と局所再発との関連2010

    • Author(s)
      若井俊文, 白井良夫, 坂田純, Korita V. Pavel, 味岡洋一, 畠山勝義
    • Journal Title

      胆道

      Volume: 24(5) Pages: 667-674

    • NAID

      10030361447

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胆管癌根治切除後の胆管切離断端に遺残した上皮内癌における早期DNA損傷修復応答と局所再発との関連2010

    • Author(s)
      若井俊文, 他
    • Journal Title

      胆道

      Volume: 24 Pages: 667-674

    • NAID

      10030361447

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma2011

    • Author(s)
      Wakai T, Shirai Y, Sakata J, Korita PV, Nagahashi M, Ajioka Y, Hatakeyama K
    • Organizer
      INTERNATIONAL SURGICAL WEEK 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Early DNA Damage Response and Local Recurrence at Ductal Resection Margins in Patients Undergoing Resection for Extrahepatic Cholangiocarcinoma2010

    • Author(s)
      Wakai T, Shirai Y, Sakata J, Korita PV, Nagahashi M, Hatakeyama K
    • Organizer
      96th Annual Clinical Congress, American College of Surgeons
    • Place of Presentation
      Washington, DC
    • Year and Date
      2010-10-05
    • Related Report
      2011 Final Research Report
  • [Presentation] <ワークショップ>肝門部胆管癌術後の胆管切離断端部遺残腫瘍におけるDNA damage responseと予後との関連2010

    • Author(s)
      若井俊文,白井良夫,坂田純,永橋昌幸,井上真,畠山勝義
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝門部胆管癌術後の胆管切離断端部遺残腫瘍におけるDNA damage responseと予後との関連2010

    • Author(s)
      若井俊文, 他
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胆管癌における53BP1を介したDNA損傷修復機構の解明及びその臨床的意義2009

    • Author(s)
      若井俊文,白井良夫,松田康伸,坂田純,味岡洋一,畠山勝義
    • Organizer
      第17回日本消化器関連学会週間JDDW 2009
    • Place of Presentation
      京都
    • Year and Date
      2009-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 胆管癌における53BP1を介したDNA損傷修復機構の解明及びその臨床的意義2009

    • Author(s)
      若井俊文
    • Organizer
      第17回日本消化器関連学会週間 JDDW 2009
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆管癌根治切除後の胆管切離断端部遺残腫瘍におけるDNA damage responseと局所再発との関連2009

    • Author(s)
      若井俊文,白井良夫,坂田純,金子和弘,永橋昌幸,畠山勝義
    • Organizer
      第45回日本胆道学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 胆管癌根治切除後の胆管切離断端部遺残腫瘍におけるDNA damage responseと局所再発との関連2009

    • Author(s)
      若井俊文
    • Organizer
      第45回日本胆道学会学術集会
    • Place of Presentation
      東京ベイ幕張(千葉)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆管断端における癌遺残が肝外胆管癌根治術後の遠隔成績に与える影響2009

    • Author(s)
      若井俊文,白井良夫,坂田純,金子和弘,永橋昌幸,畠山勝義
    • Organizer
      第64回日本消化器外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-16
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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