| Project/Area Number |
21591773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Kobe University |
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Principal Investigator |
HORI Yuichi 神戸大学, 保健学研究科, 准教授 (80248004)
|
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| Co-Investigator(Kenkyū-buntansha) |
AJIKI Tetsuo 神戸大学, 医学研究科, 特命教授 (80379403)
KU Yonson 神戸大学, 医学研究科, 教授 (40195615)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
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| Keywords | 再生医療 / 糖尿病 / 幹細胞 / 膵臓 / 組織幹細胞 |
|---|
| Research Abstract |
Although pancreatic organ transplantation is only curable option in type I diabetes mellitus, there is an extreme shortage of engraftable donor tissue. Tissue-specific stem cells are uniquely suited for regenerative medicine of diabetes mellitus. To this end, we produced pan-stem cell marker(CD133) knockout/GFP knockin mice. In CD133^(+/GFP) mice, GFP positive cells concentrated on the cells in specific region such as pancreas, liver and intestine, which is thought to be stem cell niche.
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