Isolation of adult pancreatic stem cells for regenerative medicine of diabetes mellitus
| Project/Area Number |
21591773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
HORI Yuichi 神戸大学, 保健学研究科, 准教授 (80248004)
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| Co-Investigator(Kenkyū-buntansha) |
AJIKI Tetsuo 神戸大学, 医学研究科, 特命教授 (80379403)
KU Yonson 神戸大学, 医学研究科, 教授 (40195615)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 再生医療 / 糖尿病 / 幹細胞 / 膵臓 / 組織幹細胞 |
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| Research Abstract |
Although pancreatic organ transplantation is only curable option in type I diabetes mellitus, there is an extreme shortage of engraftable donor tissue. Tissue-specific stem cells are uniquely suited for regenerative medicine of diabetes mellitus. To this end, we produced pan-stem cell marker(CD133) knockout/GFP knockin mice. In CD133^(+/GFP) mice, GFP positive cells concentrated on the cells in specific region such as pancreas, liver and intestine, which is thought to be stem cell niche.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma accompanied with inferior vena cava tumor thrombus2011
Author(s)
Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Ku Y, Murakami M
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Journal Title
J Gastroenterol
Volume: 46
Pages: 913-920
Related Report
Peer Reviewed
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