| Project/Area Number |
21591774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Hiroshima University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
SUDO Takeshi 広島大学, 医歯薬学総合研究科, 助教 (10423378)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 癌 / 膵腫瘍性疾患 / テロメア・テロメラーゼ / 免疫療法 / 遺伝子治療 |
|---|
| Research Abstract |
We did an analysis of preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunohistochemistry for preoperative diagnosis of pancreatic malignancy. The sensitivity, specificity, and overall accuracy of hTERT expression were 85%, 82%, and 84%, respectively which were higher than those of cytology. We examined telomerase activity and hTERT expression in ampullary carcinoma to determine whether these parameters could be used as indicators of prognosis. High telomerase activity and strong hTERT expression may serve as new prognostic markers for evaluating the prognosis of patients with resected ampullary carcinoma
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