Analysis of telomere and telomerase activation mechanism in pancreatic neoplasms for molecularly targeted therapy
| Project/Area Number |
21591774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIYAMA Eiso 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
SUDO Takeshi 広島大学, 医歯薬学総合研究科, 助教 (10423378)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 癌 / 膵腫瘍性疾患 / テロメア・テロメラーゼ / 免疫療法 / 遺伝子治療 |
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| Research Abstract |
We did an analysis of preoperative pancreatic juice specimens to evaluate the feasibility of detection of hTERT expression by immunohistochemistry for preoperative diagnosis of pancreatic malignancy. The sensitivity, specificity, and overall accuracy of hTERT expression were 85%, 82%, and 84%, respectively which were higher than those of cytology. We examined telomerase activity and hTERT expression in ampullary carcinoma to determine whether these parameters could be used as indicators of prognosis. High telomerase activity and strong hTERT expression may serve as new prognostic markers for evaluating the prognosis of patients with resected ampullary carcinoma
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Number of metastatic lymph nodes, but not lymph node ratio, is an independent prognostic factor after resection of pancreatic carcinoma2010
Author(s)
Murakami Y, Uemura K, Sudo T, Hayashidani Y, Hashimoto Y, Nakashima A, Yuasa Y, Kondo N, Ohge H, Sueda T
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Journal Title
J Am Coll Surg
Volume: 211(2)
Pages: 196-204
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of perioperative serum CA 19-9 levels in patients with resectable pancreatic cancer2010
Author(s)
Kondo N, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Hashimoto Y, Nakashima A, Sakabe R, Shigemoto N, Kato Y, Ohge H, Sueda T
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Journal Title
Ann Surg Oncol
Volume: 17(9)
Pages: 2321-9
Related Report
Peer Reviewed
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