The development of novel therapy for cardiac allograft vasculopathy after heart transplantation to modulate the proteoglycans formation

• Project/Area Number: 21591785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Tohoku University
• Principal Investigator: KAWAMOTO Shunsuke 東北大学, 大学院・医学系研究科, 准教授 (20400244)
• Co-Investigator(Kenkyū-buntansha): KOICHI Tabayashi 東北大学, 大学院・医学系研究科, 名誉教授 (90142942) ; IGUCHI Atsushi 東北大学, 大学院・医学系研究科, 非常勤講師 (90222851)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 移植・再生 / 循環器・高血圧 / 細胞外マトリックス / 遺伝子治療 / 移植・再生医療

Research Abstract

Focusing on overproduced proteoglycans as major components of extracellular matrix in the cardiac allograft vasculopathy after heart transplantation, vascular maturation process has been examined in newborn rabbits model to pursue possibility for proteoglycans modulation by administrating protamine sulfate to inhibit the effects of endogenous heparan sulfate proteoglycan.