Therapeutic angiogenesis using sustained release of platelet-rich plasma from biodegradable gelatin hydrogel
Project/Area Number |
21591796
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Kyoto University |
Principal Investigator |
MARUI Akira 京都大学, 医学研究科, 准教授 (60402856)
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Co-Investigator(Kenkyū-buntansha) |
MIWA Senri 京都大学, 医学研究科, 講師 (10359812)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 血管新生治療 / 多血小板血漿 / 増殖因子 / 血管新生療法 |
Research Abstract |
We used platelet-rich-plasma(PRP) as a novel method for therapeutic angiogenesis of limb ischemia. We showed that PRP contains several potent angiogenic growth factors such as SDF-1, PDGF-BB, VEGF, and bFGF. In addition, sustained release of PRP from biodegradable gelatin hydrogel facilitated angiogenesis both in normal and diabetic murine ischemic limb. This technique may be a promising option for therapeutic angiogenesis in the clinical settings.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] New therapeutic approach for impaired arteriogenesis in diabetic mouse hind limb ischemia2008
Author(s)
Bir SC, Fujita M, Marui A, Hirose K, Arai Y, Sakaguchi H, Huang Y, Esaki J, Ikeda T, Tabata Y, Komeda M
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Journal Title
Circ J
Volume: 72(4)
Pages: 633-40
NAID
Related Report
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[Journal Article] 患者まで届く再生医療生体吸収性担体を用いた重症下肢虚血に対する血管新生療法
Author(s)
丸井晃, 田畑泰彦, 柳茂樹, 山本雅哉, 米澤淳, 桂敏也, 手良向聡, 横出正之, 清水章, 中尾一和, 坂田隆造
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Journal Title
再生医療
Volume: 10巻1号
Pages: 37-44
NAID
Related Report
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[Presentation] New Therapeutic Approach for Impaired Arteriogenesis in Diabetic Mouse Hind limb Ischemia2008
Author(s)
Bir SC, Fujita M, Hirose K, Marui A, Arai Y, Sakaguchi H, Esaki J, Huang Y, Ikeda T, Tabata Y, Komeda M
Organizer
セロトニン研究会
Place of Presentation
京都
Related Report
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[Presentation] Sustained Release of Platelet-Rich Plasma, Cocktail of Potent Angiogenic Cytokines, Restores Blood Perfusion by Recruitment of Bone Marrow Derived Hematopoietic stem Cells in the Mouse Hind Limb Ischemia2008
Author(s)
Bir SC, Marui A, Esaki J, Yamahara K, Tsubota H, Fujita M, Tabata Y, Ikeda T
Organizer
American Heart Association Scientific Sessions
Place of Presentation
New Orleans, The US
Related Report
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[Presentation] A Novel Therapeutic Angiogenesis With Sustained Delivery Form Of Platelet-Rich Plasma In Mouse Hind limb Ischemia Model2008
Author(s)
Bir SC, Akira Marui, Jiro Esaki, Hisashi Sakaguchi, Yoshio Arai, Keiichi Hirose, Tadashi Ikeda, Yasuhiko Tabata, Masatoshi Fujita, FAHA.; Masashi Komeda
Organizer
ACC Annual Scientific Session
Place of Presentation
Chicago, The US
Related Report
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