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Reduction of inflammatory response in brain dead donor through activation of parasympathetic nervous system

Research Project

Project/Area Number 21591800
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKyushu University

Principal Investigator

TANOUE Yosihisa (2010-2011)  九州大学, 大学病院, 講師 (40372742)

大石 恭久 (2009)  Kyushu University, 医学研究院, 助教 (20529870)

Co-Investigator(Kenkyū-buntansha) 田ノ上 禎久  九州大学, 大学病院, 助教 (40372742)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳死ドナー / 臓器保護 / 心臓移植
Research Abstract

Remarkable dysfunction of vital organ in brain dead donor is associated with poor outcome of the organ transplantation. Excessive catecholamine release followed by inadequate response of inflammatory system plays a pivotal role in the organ dysfunction. In the current study, we attempted to inhibit the deleterious response through activation of parasympathetic nervous system.【Materials and Methods】Japanese white rabbit weighing 2. 8-3. 2 kg was divided into two groups(VNS group and sham group). In each group, rabbits were anesthetized and brain death was introduced with rapid inflation of balloon catheter inserted into cranial epidural space. In VNS group, electrical stimulation of bilateral cervical vagal nerves was initiated at 15 minutes before brain death, and continued for 180 minutes. The left ventricular systolic function and serum concentration of catecholamine was evaluated.【Results】Increment of blood pressure together with excessive catecholamine release was observed immediately after brain death in sham group. In contrast, these responses were significantly reduced in VNS group. Sham group showed gradual deterioration of the left ventricular function. However, these parameters kept unchanged in VNS group.【Conclusion】Mandatory activation of parasympathetic nervous system inhibited excessive catecholamine release followed by hyperdynamic state. This homeostatic effect reduced myocardial damage and contributed to maintain the optimal ventricular function.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2009

All Presentation (2 results)

  • [Presentation] 脳死ドナー臓器保護における副交感神経系の役割2009

    • Author(s)
      前田武俊(他5名)
    • Organizer
      第42回日本胸部外科学会九州地方会
    • Year and Date
      2009-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳死ドナー臓器保護における副交感神経系の役割2009

    • Author(s)
      前田武俊, 他5名
    • Organizer
      第42回日本胸部外科学会九州地方会
    • Place of Presentation
      iichiko 総合文化センター
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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