Establishment of disease entity for lung cancer in never-smokers
| Project/Area Number |
21591816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
YANO Tokujiro 九州大学, 医学研究院, 准教授 (80304781)
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| Co-Investigator(Kenkyū-buntansha) |
SHOJI Fumihiro 九州大学, 医学研究院, 特任助教 (90444851)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 非喫煙者肺癌 / 非小細胞肺癌 / 腺癌 / p53遺伝子変異 / 上皮細胞成長因子受容体遺伝子変異 / 酸化ストレス / 抗酸化力 / 非小細胞性肺癌 |
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| Research Abstract |
We investigated the difference of molecular biology between never-smoked non-small cell lung cancer(NSCLC) and smoked NSCLC. As far as we examined, only high incidence of EGFR mutation in never-smoked NSCLC was recognized. On the other hand, the level of AOC(anti-oxidant capacity) was significantly lower in never-smoked NSCLC patients than in ever-smoked ones although there was no significant relationship between serum OS(oxidative stress) level and smoking status. In addition, the oxidative DNA damage rate of never-smoked NSCLC patients was significantly higher than that of patients with benign diseases. In conclusion, the low AOC in never-smoked NSCLC might be attributed to the excessive oxidative DNA damages.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Feasibility study of postoperative adjuvant chemotherapy with S-1(tegaful, gimeracil, oteracil potassium) for non-small cell lung cancer-LOGIK 0601 study2010
Author(s)
Yano T, Yamazaki K, Maruyama R, Tokunaga S, Shoji F, Higashi H, Takeo S, Ichinose Y, Maehara Y
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Journal Title
Lung Cancer
Volume: 67
Pages: 184-187
Related Report
Peer Reviewed
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[Journal Article] Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking2009
Author(s)
Ohba T, Kometani T, Shoji F, Yano T, Yoshino I, Taguchi K, Kuraoka I, Oda S, Maehara Y
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Journal Title
Mutation Res
Volume: 677
Pages: 66-71
Related Report
Peer Reviewed
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