Detection of tyrosine kinase gene mutation using genotyping assay
| Project/Area Number |
21591820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
SASAKI Hidefumi 名古屋市立大学, 大学院・医学研究科, 准教授 (00336695)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Motoki 名古屋市立大学, 大学院・医学研究科, 准教授 (40315883)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 肺癌 / KIF5B/RET / FISH / EGFR / Kras / 非喫煙者 / 遺伝子転座 / 腺癌 / タバコ / NRF2 / NFE2L2 / 扁平上皮癌 / 分子標的 / 遺伝子増幅 / ジェノタイピング |
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| Research Abstract |
Novel KIF5B/RET translocation was found in lung cancer using a next-generation sequencing assay. We have developed fluorescence in situ hybridization(FISH) assay to detect KIF5B/RET transfusion gene. We have investigated Kras gene mutation statuses using genotyping assay and compared with Kras copy number, Glut-1 expression and other clinico-pathological backgrounds of lung cancers.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Long exposure of environmental tobacco smoke associated with activating EGFR mutations in never-smokers with non-small cell lung cancer2011
Author(s)
Kawaguchi T, Ando M, Kubo A, Takada M, Atagi S, Okishio K, Asami K, Matsumura A, Tsujino K, Ignatius OS, Sasaki H
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Journal Title
Clin Cancer Res
Volume: 17
Pages: 39-45
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Peer Reviewed
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[Presentation] Association of gender and passive smoking with epidermal growth factor receptor mutations in never-smokers with non-small cell lung cancer : A prospective study based on detailed passive smoking questionnarire2010
Author(s)
Kawaguchi T, Ando M, Kubo A, Takada M, Atagi S, Okishio K, Asami K, Matsumura A, Tsujino K, Sasaki H
Organizer
2010 ASCO annual meeting, central poster session
Place of Presentation
Chicago
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