The effect of RANKL inhibitor on thymic medulla formation

• Project/Area Number: 21591821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Nagoya City University
• Principal Investigator: HIKOSAKA Yu 名古屋市立大学, 大学医学研究科, 助教 (90534769)
• Co-Investigator(Kenkyū-buntansha): YANO Motoki 名古屋市立大学, 大学医学研究科, 准教授 (40315883) ; SASAKI Hidefumi 名古屋市立大学, 大学医学研究科, 准教授 (00336695) ; MORIYAMA Satoru 名古屋市立大学, 大学医学研究科, 助教 (50551264)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 免疫学 / 胸腺 / 自己寛容 / RANKL

Research Abstract

The cytokine RANK ligand(RANKL) was produced by positively selected thymocytes and regulated the cellularity of mTEC by interacting with RANK. In this study, we analyzed the effect of RANK-Fc on thymic medulla formation. At results, RANK-Fc protein did not affect the population of mTEC significantly.