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Prediction of postoperative recurrences by gene expression profiling in patients with primary resected lung cancer

Research Project

Project/Area Number 21591822
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKitasato University

Principal Investigator

IYODA Akira  北里大学, 医学部, 准教授 (10302548)

Co-Investigator(Kenkyū-buntansha) SATOH Yukitoshi  北里大学, 医学部, 教授 (90321637)
AMANO Hideki  北里大学, 医学部, 助教 (60296481)
根津 賢司  北里大学, 医学部, 講師 (10530850)
小川 史洋  北里大学, 医学部, 助教 (80383610)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺癌 / テーラーメイド治療 / 予後 / 組織型
Research Abstract

We analyzed LCNEC gene expression, gene mutation and immunohistochemical expression of known molecular targets and compared expression to that of lung adenocarcinomas. We analyzed 13 patients with primary LCNEC and 14 patients with adenocarcinoma(AC). We evaluated immunohistochemical(IHC) expression for c-KIT, human epidermal growth factor receptor type 2(HER2), and vascular endothelial growth factor(VEGF), gene mutation for EGFR, K-ras and c-kit, and gene expression using fluorescence in situ hybridization(FISH) for EGFR. In cases with LCNEC, the IHC expression of c-KIT, HER2, and VEGF were 76.9%, 30.8%, and 100%, respectively. There was a significant difference in IHC expression in c-KIT and HER2 between LCNEC and AC. Two cases of LCNEC had overexpression of HER2, and EGFR gene mutation was greater in the AC group, with only a single EGFR mutation(exon 18) identified in the LCNEC group. Although LCNEC had a higher rate of expression of c-KIT by IHC, no c-kit gene mutations were found. These findings suggest a potential role for Anti-VEGF, Anti-c-KIT, and possibly Anti-HER2 targeted agents in the treatment of LCNEC.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (13 results)

  • [Journal Article] Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma2011

    • Author(s)
      Iyoda A, Travis WD, Sarkaria IS, Jiang SX, Amano H, Sato Y, Saegusa M, Rusch VW, Satoh Y
    • Journal Title

      Exp Therap Med

      Volume: 2 Pages: 1041-1045

    • Related Report
      2011 Final Research Report
  • [Journal Article] Prediction of postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease2011

    • Author(s)
      Iyoda A, Jiang SX, Amano H, Ogawa F, Matsui Y, Kurouzu N, Hara H, Nezu K, Mikami T, Saegusa M, Satoh Y
    • Journal Title

      Exp Therap Med

      Volume: 2 Pages: 1073-1076

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma2011

    • Author(s)
      Iyoda A, Travis WD, 他
    • Journal Title

      Exp Ther Med

      Volume: 2 Issue: 6 Pages: 1041-1045

    • DOI

      10.3892/etm.2011.343

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease2011

    • Author(s)
      Iyoda A, Jiang SX, 他
    • Journal Title

      Exp Ther Med

      Volume: 2 Issue: 6 Pages: 1073-1076

    • DOI

      10.3892/etm.2011.342

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The current status and future direction of surgical treatments for lung cancer2010

    • Author(s)
      Rusch VW, 伊豫田明, 吉村博邦, 佐藤之俊, 早川和重
    • Journal Title

      肺癌

      Volume: 50 Pages: 253-264

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Predictors of postoperative survival in patients with locally advanced non-small cell lung carcinoma2010

    • Author(s)
      Iyoda A, Hiroshima K, Moriya Y, Yoshida S, Suzuki M, Shibuya K, Yoshino I
    • Journal Title

      Surgery Today

      Volume: 40 Pages: 725-728

    • NAID

      10027396937

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 肺神経内分泌腫瘍に対する手術および術後補助療法に関する検討2011

    • Author(s)
      伊豫田明、蒋世旭、山崎宏継、石井大、中島裕康、小川史洋、松井啓夫、塩見和、原英則、久朗津尚美、益田典幸、早川和重、佐藤之俊
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺神経内分泌腫瘍に対する手術および術後補助療法に関する検討2011

    • Author(s)
      伊豫田明, 他
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺大細胞神経内分泌癌に対する遺伝子変異、蛋白発現解析2011

    • Author(s)
      伊豫田明、蒋世旭、根津賢司、小川史洋、松井啓夫、天野英樹、原英則、久朗津尚美、益田典幸、早川和重、佐藤之俊
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      誌上発表(予定東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺大細胞神経内分泌癌に対する遺伝子変異、蛋白発現解析2011

    • Author(s)
      伊豫田明, 他
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (東京開催予定→震災により)(誌上発表に変更)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺大細胞神経内分泌癌に対する分子標的治療を目的とした遺伝子変異、蛋白発現解析2010

    • Author(s)
      伊豫田明、蒋世旭、根津賢司、小川史洋、松井啓夫、天野英樹、原英則、久朗津尚美、益田典幸、早川和重、佐藤之俊
    • Organizer
      第51回日本肺癌学会総会・ワークショップ
    • Place of Presentation
      広島国際会議場(広島県)
    • Year and Date
      2010-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺大細胞神経内分泌癌に対する分子標的治療を目的とした遺伝子変異、蛋白発現解析2010

    • Author(s)
      伊豫田明
    • Organizer
      日本肺癌学会総会・ワークショップ
    • Place of Presentation
      広島国際会議場(広島県)
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺大細胞神経内分泌癌切除症例における術後再発の検討2010

    • Author(s)
      伊豫田明、小川史洋、松井啓夫、天野英樹、久朗津尚美、原英則、根津賢司、吉村博邦、佐藤之俊
    • Organizer
      第63回日本胸部外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺大細胞神経内分泌癌切除症例における術後再発の検討2010

    • Author(s)
      伊豫田明
    • Organizer
      日本胸部外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 間質性肺炎合併肺癌における術後急性増悪関連因子の検討2010

    • Author(s)
      伊豫田明、秋山啓輔、小川史洋、伊藤諭子、松井啓夫、天野英樹、原英則、根津賢司、吉村博邦、佐藤之俊
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 間質性肺炎合併肺癌における術後急性増悪関連因子の検討2010

    • Author(s)
      伊豫田明
    • Organizer
      日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌治療のスタンダード-外科治療と補助療法との組み合わせ-肺大細胞神経内分泌癌の治療経験から2010

    • Author(s)
      伊豫田明、蒋世旭、根津賢司、小川史洋、松井啓夫、天野英樹、原英則、岡安勲、益田典幸、早川和重、吉村博邦、佐藤之俊
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-04-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌治療のスタンダード-外科治療と補助療法との組み合わせ-肺大細胞神経内分泌癌の治療経験から2010

    • Author(s)
      伊豫田明
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Postoperative recurrence and the prognosis in patients with pulmonary large cell neuroendocrine carcinoma2009

    • Author(s)
      Iyoda A, Jiang SX, Ijima D, Nezu K, Ogawa F, Matsui Y, Amano H, Hara H, Okayasu I, Masuda N, Hayakawa K, Yoshimura H, Satoh Y
    • Organizer
      13th World Conference on Lung Cancer
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-08-02
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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