A mouse model of lung tissue transplantation with biocompatible scaffold materials

• Project/Area Number: 21591825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: SAWAFUJI Makoto 慶應義塾大学, 医学部, 講師(非常勤) (10226079)
• Co-Investigator(Kenkyū-buntansha): WATANABE Masazumi 慶應義塾大学, 医学部, 教授 (90201227) ; IZUMI Yotaro 慶應義塾大学, 医学部, 講師 (90245506) ; KOHNO Mitsutomo 慶應義塾大学, 医学部, 講師 (10276272)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 呼吸器外科学 / 移植・再生医療 / 呼吸器外科

Research Abstract

We developed a mouse model of lung tissue transplantation using biocompatible scaffold materials. Fragments of fetal lung tissue taking from GFP mice were infused with biocompatible materials into the lungs of wild type recipient mice. Grafts expressing GFP were observed for three days after transplantation.

Research Products

• [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice (2012)
  • Author(s): Kohno M, Watanabe M, Izumi Y, Tasaka S, Kitagawa Y, Maruyama I, Kobayashi K
  • Journal Title: Thorac Cardiovasc Surg Volume: 60(2) Pages: 124-30
  • Peer Reviewed
• [Journal Article] Treatment of intractable interstitial lung injury with alemtuzumab after lung transplantation (2011)
  • Author(s): Kohno M, Perch M, Andersen E, Carlsen J, Andersen CB, Iversen M
  • Journal Title: Transplant Proc Volume: 43(5) Pages: 1868-70
  • Peer Reviewed
• [Journal Article] Airway administration of dexamethasone, 3'-5'-cyclic adenosine monophosphate, and isobutylmethylxanthine facilitates compensatory lung growth in adult mice (2011)
  • Author(s): Takahashi Y, Izumi Y, Kohno M, Kawamura M, Ikeda E, Nomori H.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 300(3)
  • Peer Reviewed
• [Presentation] ラット肺瘻モデルにおけるフィブリン糊肺実質内充填による肺瘻閉鎖 (2009)
  • Author(s): 江間俊哉、河野光智、儀賀理暁、田島敦志、泉陽太郎、渡辺真純、川村雅文、堀之内宏久、小林紘一
  • Organizer: 第26回日本呼吸器外科学会総会
• [Presentation] 生体適合性ゲル化物質の肺実質内充填による肺瘻閉鎖の実験的検討 (2009)
  • Author(s): 河野光智、江間俊哉、儀賀理暁、泉陽太郎、渡辺真純、堀之内宏久、川村雅文、小林紘一
  • Organizer: 第26回日本呼吸器外科学会総会