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New interventional approach using LED plus lens for treatment of malignant mesothelioma

Research Project

Project/Area Number 21591826
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTokyo Medical University

Principal Investigator

USUDA Jitsuo  東京医科大学, 医学部, 准教授 (60338803)

Co-Investigator(Kenkyū-buntansha) IKEDA Norihiko  東京医科大学, 外科学, 教授 (70246205)
一ノ瀬 修二  東京医科大学, 医学部, 助教 (10424491)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords光線力学治療 / 胸膜中皮腫 / 発光ダイオード / 悪性胸膜中皮腫 / LED / PDT / 光線力学的治療
Research Abstract

It was able to gather rays of light from LED using lens and photodynamic therapy using LED plus lens killed malignant mesothelioma cells. Moreover, combination treatment, consisting of pemetrexed followed by NPe6-PDT, should be further investigated as a new treatment modality for malignant pleural mesothelioma. In the future, this combination treatment, PDT using LED plus lens and pemetrexed, may contribute to a reduction in local recurrence and a prolonged survival period in patients with malignant pleural mesothelioma.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (56 results)

All 2012 2011 2010 2009

All Journal Article (23 results) (of which Peer Reviewed: 5 results) Presentation (26 results) Book (7 results)

  • [Journal Article] 肺癌に対する治療戦略2012

    • Author(s)
      臼田実男、池田徳彦
    • Journal Title

      光アライアンス

      Volume: 23巻7号 Pages: 1-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] レーザーによる中心型肺癌の早期発見と内視鏡治療2012

    • Author(s)
      臼田実男、池田徳彦
    • Journal Title

      光アライアンス

      Volume: 23巻,7号 Pages: 23-26

    • Related Report
      2011 Final Research Report
  • [Journal Article] 光線力学的診断と治療2012

    • Author(s)
      臼田実男、池田徳彦
    • Journal Title

      医学のあゆみ

      Volume: 240巻 Pages: 501-504

    • Related Report
      2011 Final Research Report
  • [Journal Article] 光線力学的療法(PDT)の現状と将来展望2012

    • Author(s)
      奥仲哲弥、坂庭信行、臼田実男、池田徳彦
    • Journal Title

      Oplus E(OPTIC ELECTRONICS)

      Volume: 34巻,2号 Pages: 135-138

    • Related Report
      2011 Final Research Report
  • [Journal Article] Molecular determinants of photodynamic therapy for lung cancers2011

    • Author(s)
      Usuda J., Ichinose S., Ishizumi T., Ohtani K., Inoue T., Imai K., Maehara S., Ohira T., Kato H., Ikeda N
    • Journal Title

      Lasers Surg Med

      Volume: 43 Pages: 591-599

    • Related Report
      2011 Final Research Report
  • [Journal Article] New aspects of photodynamic therapy for central type early lung cancer2011

    • Author(s)
      Ikeda N, Usuda J, Kato H, Ishizumi T, Ichinose S, Ohtani K, Honda H, Furukawa K, Okunaka T, Tsutsui H
    • Journal Title

      Lasers Surg Med

      Volume: 43 Pages: 749-754

    • Related Report
      2011 Final Research Report
  • [Journal Article] 気管支内視鏡検査と画像所見のABC画像の読影(5)癌光診断2011

    • Author(s)
      臼田実男、池田徳彦
    • Journal Title

      レスピレーションリサーチファンデーション・呼吸

      Volume: 30巻 Pages: 134-138

    • Related Report
      2011 Final Research Report
  • [Journal Article] 肺癌の病態と治療・光線力学的治療2011

    • Author(s)
      石角太一郎、臼田実男、池田徳彦
    • Journal Title

      からだの科学(日本評論社)

      Volume: 270巻 Pages: 99-102

    • Related Report
      2011 Final Research Report
  • [Journal Article] がんにおける光線力学的治療法(PDT)の現状2011

    • Author(s)
      奥仲哲弥、坂庭信行、臼田実男、池田徳彦
    • Journal Title

      レーザー研究

      Volume: 39巻 Pages: 101-105

    • Related Report
      2011 Final Research Report
  • [Journal Article] Molecular determinants of photodynamic therapy for lung cancers2011

    • Author(s)
      Usuda J, et al
    • Journal Title

      Lasers in Surgery and Medicine

      Volume: 43 Issue: 7 Pages: 591-599

    • DOI

      10.1002/lsm.21097

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New aspects of photodynamic therapy for central type early stage lung cancer2011

    • Author(s)
      Ikeda N, et al
    • Journal Title

      Lasers in Surgery and Medicine

      Volume: 43 Issue: 7 Pages: 749-754

    • DOI

      10.1002/lsm.21091

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways> 1.0cm in diameter2010

    • Author(s)
      Usuda J., Ichinose S., Ishizumi T., Hayashi H., Ohtani K., Maehara S., Ono S., Honda H., Kajiwara N., Uchida O., Tsutsui H., Ohira T., Kato H., Ikeda N.
    • Journal Title

      Clin Cancer Res

      Volume: 16 Pages: 2198-2204

    • Related Report
      2011 Final Research Report
  • [Journal Article] Management of multiple primary lung cancer in patients with centrally located early cancer lesions2010

    • Author(s)
      Usuda J., Ichinose S., Ishizumi T., Hayashi H., Hayashi H., Ohtani K., Maehara S., Ono S., Kajiwara N., Uchida O., Tsutsui H., Ohira T., Kato H., Ikeda N.
    • Journal Title

      J Thorac Oncol

      Volume: 5 Pages: 62-68

    • Related Report
      2011 Final Research Report
  • [Journal Article] Breast cancer resistant protein(BCRP) is a molecular determinant of the outcome of photodynamic therapy(PDT) for centrally located early lung cancer2010

    • Author(s)
      Usuda J., Tsunoda Y., Ichinose S., Ishizumi T., Ohtani K., Maehara S., Ono S., Tsutsui H., Ohira T., Okunaka T., Furukawa K., Sugimoto Y., Kato H., Ikeda N.
    • Journal Title

      Lung Cancer

      Volume: 67 Pages: 198-204

    • Related Report
      2011 Final Research Report
  • [Journal Article] Novel photodynamic therapy against biliary tract carcinoma using mono-L-aspartyl chlorine e6 : basic evaluation for its feasibility and efficacy2010

    • Author(s)
      Kasuya K, Shimazu M, Suzuki M, Kuroiwa Y, Usuda J, Itoi T, Tsuchida A, Aoki T.
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 17 Pages: 313-321

    • NAID

      10027422793

    • Related Report
      2011 Final Research Report
  • [Journal Article] 我が国におけるPDT(Photodynamic therapy)開発とレーザー装置の変遷2010

    • Author(s)
      加藤治文、臼田実男
    • Journal Title

      レーザー研究

      Volume: 38巻 Pages: 733-733

    • Related Report
      2011 Final Research Report
  • [Journal Article] Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways >1.0cm in diameter2010

    • Author(s)
      Usuda J, et al.
    • Journal Title

      Clinical Cancer Research

      Volume: 16 Pages: 2198-2204

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel photodynamic therapy against biliary tract carcinoma using mono-L-aspartyl chlorine e62010

    • Author(s)
      Kasuya K, Usuda J, et al
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 17 Pages: 313-321

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways>1.0cm in diameter2010

    • Author(s)
      Usuda J, et al.
    • Journal Title

      Clinical Cancer Research 16

      Pages: 2198-2204

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集内視鏡における診断・治療法の新展開治療1)気管支内腫瘍の光線力学的治療2009

    • Author(s)
      臼田実男、池田徳彦
    • Journal Title

      呼吸器科(科学評論社)

      Volume: 14巻 Pages: 492-497

    • Related Report
      2011 Final Research Report
  • [Journal Article] レーザー治療・高周波治療2009

    • Author(s)
      大谷圭志、臼田実男、嶋田喜久、相馬孝博、池田徳彦
    • Journal Title

      胸部外科(南江堂)

      Volume: 62巻 Pages: 739-743

    • Related Report
      2011 Final Research Report
  • [Journal Article] 自家蛍光気管支鏡を用いた蛍光診断-その変遷と今後の展望2009

    • Author(s)
      本多英俊、山口学、大谷圭志、臼田実男、池田紀彦
    • Journal Title

      日本レーザー医学会誌

      Volume: 30巻 Pages: 31-36

    • NAID

      10024789458

    • Related Report
      2011 Final Research Report
  • [Journal Article] 特集生活習慣病クリニック予防と治療効果対策肺癌2009

    • Author(s)
      奥仲哲弥、臼田実男、池田紀彦
    • Journal Title

      モダンフィジシャン(新興医学出版社)

      Volume: 29巻 Pages: 871-874

    • Related Report
      2011 Final Research Report
  • [Presentation] Photodynamic therapy for lung cancers2011

    • Author(s)
      Usuda J, et al
    • Organizer
      13th IPA(International Photodynamic Association) World congress
    • Place of Presentation
      Innsbrunck, Austria
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Photodynamic therapy using NPe6 for multiple primary lung cancers2011

    • Author(s)
      Usuda J.
    • Organizer
      The 3^<rd> Symposium of the Asian Photodynamic Association
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Diagnosis and Treatment Outcomes of Early Central Lung Cancer-including a case of synchronous double squamous primaries2011

    • Author(s)
      Honda H, Usuda J, Ikeda N.
    • Organizer
      14^<th> World Congress on Lung Cancer
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] Photodynamic therapy for lung cancers2011

    • Author(s)
      Usuda J.
    • Organizer
      13^<th> International Photodynamic Association World Congress
    • Place of Presentation
      Innsbruck, Austria
    • Related Report
      2011 Final Research Report
  • [Presentation] Photodynamic therapy using NPe6 for multiple primary lung cancers2011

    • Author(s)
      Usuda J.
    • Organizer
      14^<th> World Congress on Lung Cancer
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌に対するレーザー治療2011

    • Author(s)
      臼田実男
    • Organizer
      第18回気管支鏡専門医大会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 呼吸器内視鏡の夢を語るー気管支鏡治療の立場から2011

    • Author(s)
      臼田実男, (11人中1番目)
    • Organizer
      第34回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌に対する光線力学的治療2011

    • Author(s)
      臼田実男, (9人中1番目)
    • Organizer
      第21回日本光線力学学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経内分泌肺癌におけるKotho発現と予後との関係2011

    • Author(s)
      臼田実男, (11人中1番目)
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌に対するレーザー治療2011

    • Author(s)
      臼田実男、奥仲哲弥、池田紀彦
    • Organizer
      第32回日本レーザー医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways >1.0cm in diameter2010

    • Author(s)
      Usuda J
    • Organizer
      American Association of Clinical Oncology Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways more than 1.0 cm in diameter2010

    • Author(s)
      Usuda J, Ikeda N, Kato H, Ohira T.
    • Organizer
      2010 ASCO Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways more than 1.0 cm in diameter2010

    • Author(s)
      Usuda J.
    • Organizer
      16^<th> World Congress for Bronchology
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2011 Final Research Report
  • [Presentation] Photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways2010

    • Author(s)
      Usuda J, Kato H, Ikeda N.
    • Organizer
      24th International Congress Laser Medicine and International Academy of Laser Medicine and Surgery(IALMS) Courses
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Management of Multiple Primary Lung Cancer Patients with Centrally Located Early Cancer Lesions2010

    • Author(s)
      Usuda J.
    • Organizer
      4th Asia Pacific Lung Cancer Conference
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌に対する最新のレーザー治療2010

    • Author(s)
      臼田実男, (10人中1番目)
    • Organizer
      レーザー学会学術講演会第30回年次大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 末梢型肺癌に対する光線力学的治療の検討2010

    • Author(s)
      臼田実男, (11人中1番目)
    • Organizer
      第33回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] レザフィリンの進行肺がん治療への応用について(ランチョンセミナー)2010

    • Author(s)
      臼田実男, (10人中1番目)
    • Organizer
      第20回日本光線力学学会学術講演会
    • Place of Presentation
      福井
    • Related Report
      2011 Final Research Report
  • [Presentation] 外科におけるPDT2010

    • Author(s)
      臼田実男, (7人中1番目)
    • Organizer
      第32回日本光医学・光生物学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺大細胞神経内分泌癌におけるアンチエイジング遺伝子Klotho発現の臨床的意義2010

    • Author(s)
      臼田実男, (10人中1番目)
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌に対する最新のレーザー治療2010

    • Author(s)
      臼田実男, (9人中1番目)
    • Organizer
      第31回日本レーザー医学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] Outcome of photodynamic therapy using NPe6 for bronchogenic carcinomas in central airways more than 1.0 cm in diameter2010

    • Author(s)
      Usuda J
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Combined therapy with photodynamic therapy and chemotherapy using pemetrexed for malignant mesothelioma2009

    • Author(s)
      Usuda J
    • Organizer
      The 4th Seoul National University Bundang Hospital PDT Colloquium
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Breast cancer resistant protein(BCRP) is a molecular determinant of the outcome of photodynamic therapy(PDT) for centrally located early lung cancer2009

    • Author(s)
      Usuda J.
    • Organizer
      12^<th> International Photodynamic Association World Congress
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Combined therapy with photodynamic therapy and chemotherapy using pemetrexed for malignant mesothelioma2009

    • Author(s)
      Usuda J.
    • Organizer
      The 5th Meeting of Asian Thoracic Surgical Club
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Breast cancer resistant protein(BCRP) is a molecular determinant of PDT using Photofrin2009

    • Author(s)
      Usuda J.
    • Organizer
      13th World Conference on Lung Cancer
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Book] 17光線力学治療気管支鏡ベストテクニック, 1版2012

    • Author(s)
      臼田実男、池田徳彦
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] 自家蛍光気管支鏡気管支鏡ベストテクニック, 1版2012

    • Author(s)
      池田徳彦、本多英俊、臼田実男
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] Therapeutic Bronchoscopy : Photodynamic therapy in Lung Cancers Flexible Bronchoscopy2012

    • Author(s)
      Kato H and Usuda J.
    • Related Report
      2011 Final Research Report
  • [Book] 12肺癌ー(6)特殊な治療ーa)光線力学的治療インフォームドコンセントのための図説シリーズ肺癌,改訂4版2011

    • Author(s)
      臼田実男
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Final Research Report
  • [Book] 第11章、光線力学的治療の適応拡大、次世代光医療-レーザー技術の臨床への橋渡し, 1版2010

    • Author(s)
      奥仲哲弥、臼田実男
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] 4肺がんの治療-2)特殊な治療-(2)光線力学的治療インフォームドコンセントのための図説シリーズ肺癌,改訂3版2009

    • Author(s)
      池田徳彦、臼田実男
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Final Research Report
  • [Book] 5最新の癌治療-レーザー療法がん診療update・日本医師会雑誌特別号2009

    • Author(s)
      加藤治文、臼田実男、萩原優、河野貴文、加藤靖文、稲田秀洋
    • Publisher
      日本医師会
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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