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Assessment of diffusion-weighted imaging and genetic analysis related to water molecules of lung cancers

Research Project

Project/Area Number 21591828
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKanazawa Medical University

Principal Investigator

USUDA Katsuo  金沢医科大学, 医学部, 教授 (00324046)

Co-Investigator(Kenkyū-buntansha) UEDA Yoshimichi  金沢医科大学, 医学部, 教授 (50271375)
MATOBA Munetaka  金沢医科大学, 医学部, 准教授 (90288308)
SAGAWA Motoyasu  金沢医科大学, 医学部, 教授 (70292274)
SAKUMA Tsutomu  金沢医科大学, 医学部, 教授 (90215674)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords呼吸器外科学 / 肺癌 / Magnetic Resonance Imaging(MRI) / 拡散強調画像 / FDG-PET / ADC(Apparent diffusion coefficient) / SUV max / 画像診断 / 正診率 / SUV_max / ADC(Apparent diffusion coefficient))
Research Abstract

DWI is superior to PET-CT in detection of primary lesions and nodal assessment of non-small cell lung cancers. DWI is superior to PET-CT in distinguishing benign from malignant pulmonary nodules. DWI signal intensity and distribution can represent the amount of cancer cells and their distribution in the carcinoma. ADC value of DWI is associated with tumor cellular density and angiogenesis expressed by CD31 activity.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (15 results) Book (1 results)

  • [Journal Article] Significance of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Lung Cancer : Correlation of the Apparent Diffusion Coefficient Value with Clinicopathological Prognostic Factors2012

    • Author(s)
      Zhao XT, et.al
    • Journal Title

      J Kanazawa Med Univ

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging (DWI) signal intensity and distribution represents the amount of cancer cells and their distribution in primary lung cancer2012

    • Author(s)
      Usuda K, et.al.
    • Journal Title

      Clinical Imaging

      Volume: (In press) Issue: 2 Pages: 265-272

    • DOI

      10.1016/j.clinimag.2012.04.026

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging is superior to PET in the detection and nodal assessment of lung cancers2011

    • Author(s)
      Usuda K, Zhao XT, Sagawa M, Matoba M, Kuginuki Y, Ueda Y, Sakuma T
    • Journal Title

      Ann. Thorac. Surg

      Volume: 91 Pages: 1689-1695

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging(DWI) signal intensity and distribution represents the amount of cancer cells and their distribution in primary lung cancer2011

    • Author(s)
      Usuda K, Zhao XT, Sagawa M, Aikawa H, Ueno M, Tanaka M, Machid Y, Matoba M, Ueda Y. Sakuma T
    • Journal Title

      Clinical Imaging

      Volume: 91 Pages: 1689-1695

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging is superior to PET in the detection and nodal assessment of lung cancers2011

    • Author(s)
      Usuda K, et.al.
    • Journal Title

      Ann.Thorac.Surg.

      Volume: 91 Issue: 6 Pages: 1689-1695

    • DOI

      10.1016/j.athoracsur.2011.02.037

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion-weighted imaging is superior to PET in the detection and nodal assessment of lung cancers.2011

    • Author(s)
      Usuda K.
    • Journal Title

      Ann.Thorac.Surg.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between glucose transporter-1 expression and 18-fluoro-2-deoxy-glucose uptake on positron emission tomography in lung cancer2010

    • Author(s)
      Usuda K, Sagawa M, Aikawa H, Ueno M, Tanaka M, Machida Y, Zhao XT, Ueda Y, Higashi K, Sakuma T
    • Journal Title

      Gen. Thorac. Cardiovasc. Surg

      Volume: 58 Pages: 405-410

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between glucose transporter-1 expression and 18-fluoro-2-deoxy-glucose uptake on positron emission tomography in lung cancer.2010

    • Author(s)
      Usuda K
    • Journal Title

      Gen.Thorac. Cardiovasc. Surg. 58(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺癌のMR拡散強調画像所見に対する病理学及び免疫染色所見の検討2011

    • Author(s)
      趙希?、薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 上田善道, 佐久間勉
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪市.(大阪国際会議場)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌例でのEGFR遺伝子変異とMR拡散強調画像・FDG-PET・病理所見との比較検討2011

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, Zhao XiTong, 的場宗孝, 上田善道, 佐久間勉
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪市.(大阪国際会議場)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌例でのEGFR遺伝子変異とMR拡散強調画像・FDG-PET・病理所見との比較検討2011

    • Author(s)
      薄田勝男, 他
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪市(大阪国際会議場)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺癌のMR拡散強調画像所見に対する病理学及び免疫染色所見の検討2011

    • Author(s)
      趙希〓、薄田勝男, 他
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪市(大阪国際会議場)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparative study of diffusion-weighted magnetic resonance imaging and FDG-PET to detect lung cancer and its nodal involvement2011

    • Author(s)
      Usuda K, Sagawa M, Zhao XT, Aikawa H, Ueno M, Tanaka M, Machida Y, Matoba M, Ueda Y, Sakuma T
    • Organizer
      European Congress of Radiology
    • Place of Presentation
      Vienna.(Austria Center Vienna)
    • Year and Date
      2011-03-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌の術前N因子診断において胸部MR拡散強調画像がFDG-PETより有用であった5症例の検討2010

    • Author(s)
      田中良, 薄田勝男, 上野正克, 町田雄一郎, 相川広一, 的場宗孝, 佐川元保, 佐久間勉
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島市.(広島国際会議場)
    • Year and Date
      2010-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 胸部病変に対するMR拡散強調画像の有用性の検討2010

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, Xi Tong Zhao, 的場宗孝, 上田善道, 佐久間勉
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島市.(広島国際会議場)
    • Year and Date
      2010-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 胸部病変に対するMR拡散強調画像の有用性の検討2010

    • Author(s)
      薄田勝男
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島市ANAクラウンプラザホテル広島
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌の病期診断に対するMR拡散強調画像とFDG-PETの有用性の検討2010

    • Author(s)
      薄田勝男, 趙希?, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 佐藤智美, 的場宗孝, 上田善道, 佐久間勉
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台市.(仙台国際センター)
    • Year and Date
      2010-05-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌例におけるMR拡散強調画像所見に対する病理学所見の検討2010

    • Author(s)
      趙希?, 薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 上田善道, 的場宗孝, 佐久間勉
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台市.(仙台国際センター)
    • Year and Date
      2010-05-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌例のMR拡散強調画像の信号パターンの画像解析2010

    • Author(s)
      薄田勝男, 趙希?, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 佐藤智美, 的場宗孝, 上田善道, 佐久間勉
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台市.(仙台国際センター)
    • Year and Date
      2010-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 術前胸部MRI拡散強調画像が乳癌の肺転移診断に有用であった1例2010

    • Author(s)
      佐藤智美、町田雄一郎、上野正克, 田中良, 相川広一, 薄田勝男, 田中聡子、佐川元保, 佐久間勉
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台市.(仙台国際センター)
    • Year and Date
      2010-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] MRI拡散強調画像が術前リンパ節転移の評価に有益であった肺癌切除例の1例2010

    • Author(s)
      相川広一, 薄田勝男, 田中良, 町田雄一郎, 上野正克, 佐川元保, 佐久間勉
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台市.(仙台国際センター)
    • Year and Date
      2010-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺病変に対するMR拡散強調画像の検討2009

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 的場正孝, 上田善道, 佐久間勉
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京都.(京王プラザホテル)
    • Year and Date
      2009-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺病変に対するMR拡散強調画像の検討2009

    • Author(s)
      薄田勝男
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京新宿京王プラザホテル
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Book] 縦隔セミノーマ.縦隔腫瘍.縦隔疾患.呼吸器症候群(第2版)2009

    • Author(s)
      薄田勝男
    • Total Pages
      5
    • Publisher
      別冊日本臨牀、大阪
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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