| Project/Area Number |
21591830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
YASUDA Manabu 産業医科大学, 医学部, 非常勤医師 (50352307)
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| Co-Investigator(Kenkyū-buntansha) |
HANAGIRI Takeshi 産業医科大学, 医学部, 准教授 (30299614)
TAKENOYAMA Mituhiro 産業医科大学, 医学部, 非常勤講師 (10309966)
安元 公正 産業医科大学, 医学部, 教授 (30150452)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アスベスト / 肺癌 / 腫瘍抗原 / Annexin A2 / SEREX |
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| Research Abstract |
This study analysed the humoral immune response in lung cancer patients with asbestos exposure in order to identify new surrogate markers of the carcinogenic risk in populations exposed to asbestos. A serological analysis identified five distinct antigens reactive with IgG derived from a lung cancer patient with high asbestos exposure. In one of the isolated antigens, quantitative RT-PCR indicated that annexin A2(AnxA2) was overexpressed in lung cancer tissues and normal lung from patients with high asbestos exposure. Antibody against AnxA2 was detected in 9/15(60%) of lung cancer patients with high asbestos exposure ; however, in only 1/12(8%) of lung cancer patients with low asbestos exposure. AnxA2 was also overexpressed in malignant mesothelioma cells, and the antibody was also positive in 9/15(60%) of patients with malignant mesothelioma. Furthermore, this study also focused on the clinical significance of pre-operative serum levels of Osteopontin(OPN) in patients with NSCLC who underwent a complete resection. The pre-operative serum OPN level of each patient was a useful predictor of an unfavorable prognosis, however, it was not associated with previous asbestos exposure. In conclusion, the antibody titer against AnxA2 may be a potentially useful new diagnostic surrogate marker for asbestos-related lung cancer and malignant mesothelioma.
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