Analysis of heterogeneity related g factors in carcinogenesis of lung cancer.
| Project/Area Number |
21591831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEMATSU Yoshiki 産業医科大学, 医学部, 助教 (10546469)
YASUMOTO Kosei 産業医科大学, 医学部, 名誉教授 (30150452)
ONO Kenji 産業医科大学, 医学部, 助教 (40369062)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | EGFR / lung cancer / heterogeneity |
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| Research Abstract |
Lung cancer has been the most common cancer in the world for several decades and the prognosis is currently unacceptable. Activating mutations in the epidermal growth factor receptor(EGFR) gene in lung adenocarcinoma are associated with a dramatic clinical response to EGFR-tyrosine kinase inhibitors(TKI). However, patients often experience a relapse. However, the whole picture and biological significance regarding acquired resistance remains unclear. in this research. We planned the experiment to establish the visualization for the cancer cell transferred for GFR gene transiently and stably by using lung cancer cell lines, measurement for tumor growth potential by co-culture, and investigation of relationship between mix ratio and drug resistance to EGFR-TKI. We also examined the clinical feature of adenosquamous cell carcinoma as a representative model for heterogeneity of the tumor. Furtherer, our results showed that various alterations in gene or protein expression can account for all resistant mechanisms and this phenomenon suggests the existence of complicated relationships among acquired resistance-related genes. We also reported that T790M may thus be a useful marker for predicting a favorable prognosis in Japanese patients treated by an EGFR-TKI.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Preoperative CYFRA 21-1 and CEA as prognostic factors in patientswith stage I non-small cell lung cancer2011
Author(s)
Hanagiri T, Sugaya M, Takenaka M, Oka S, Baba T, Shigematsu Y, Nagata Y, Shimokawa H, Uramoto H, Takenoyama M, Yasumoto K, Tanaka F
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Journal Title
Lung Cancer
Volume: 74
Issue: 1
Pages: 112-117
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical Relevance of TAp73 andΔNp73 Protein Expression in Ovarian Cancer : A Series of 83 Cases and Review of the Literature2011
Author(s)
Hofstetter G, Berger A, Chamson M, Muller-Holzner E, Reimer D, Ulmer H, Uramoto H, Marth C, G Zeimet A, Zeillinger R, Concin N
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Journal Title
Int J Gynecol Pathol
Volume: 30
Issue: 6
Pages: 527-531
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort2011
Author(s)
Yano S, Yamada T, Takeuchi S, Tachibana K, Minami Y, Yatabe Y, Mitsudomi T, Tanaka H, Kimura T, Kudoh S, Nokihara H, Ohe Y, Yokota J, Uramoto U, Yasumoto Y, Kiura K, Higashiyama M, Oda M, Saito H, Yoshida J, Kondoh K, Noguchi M.
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Journal Title
J Thorac Oncol
Volume: 6
Issue: 12
Pages: 2011-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Comprehensive Molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status2010
Author(s)
Onitsuka T, Uramoto H, Ono K, Takenoyama M, Hanagiri T, Oyama T, Izumi H, Kohno K, Yasumoto K
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Journal Title
J Thorac Oncol
Volume: 5
Issue: 5
Pages: 591-596
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Loss of PTEN expression by blocking nuclear translocation of EGR1 in Gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations2010
Author(s)
Yamamoto C, Basaki Y, Kawahara A, Nakashima K, Kage M, Izumi H, Kohno K, Uramoto H, Yasumoto K, Kuwano M, Ono M
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Journal Title
Cancer Research
Volume: 70
Issue: 21
Pages: 8715-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between lymphangiogenesis-/micrometastasis-and adhesion-related molecules in resected stage I NSCLC2010
Author(s)
Yamashita T, Uramoto H, Onitsuka T, Ono K, Baba T, So T, So T, Takenoyama M, Hanagiri T, Oyama T, Yasumoto K
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Journal Title
Lung Cancer
Volume: 70
Issue: 3
Pages: 320-328
DOI
Related Report
Peer Reviewed
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[Presentation] ヒト非小細胞肺癌のゲフィチニブ耐性獲得におけるPTEN欠失とその制御メカニズム2010
Author(s)
山本千鶴子, 馬崎雄二, 村上雄一, 河原明彦, 鹿毛政義, 浦本秀隆, 安元公正, 和泉弘人, 河野公俊, 桑野信彦, 小野眞弓
Organizer
第69回日本癌学会学術総会
Place of Presentation
リーガロイヤルホテル大阪
Related Report
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[Presentation] Epithelial-mesenchymal transition status and EGFR mutation on EGFR-TKI-resistant lung adenocarcinoma2010
Author(s)
Uramoto H, Onitsuka T, Shimokawa H, Iwata T, Nakagawa M, Nagata Y, Shigematsu Y, Baba T, Ono K, Takenoyama M, Hanagiri T, Oyama T, Yasumoto K
Organizer
9th International Conference of The Asian Clinical Oncology Society
Place of Presentation
岐阜グランドホテル
Related Report
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