Ultimate non-invasive estimation for cerebral blood flow and metabolism using by high field MR imaging

• Project/Area Number: 21591832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: INOUE Takashi 東北大学, 大学院・医学系研究科, 非常勤講師 (70326651)
• Co-Investigator(Kenkyū-buntansha): TOMINAGA Teiji 東北大学, 大学院・医学研究科, 教授 (00217548)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 神経画像診断学 / MRI / 脳血流 / 脳血管性障害 / 脳代謝 / 超高磁場 / 非侵襲 / 酸素摂取率 / 脳卒中

Research Abstract

Non-invasive estimation for cerebral blood flow and metabolism using by high field MR imaging was developed. Flow-sensitive attenuated inversion recovery method was clarified to measure cerebral blood flow in patients with stroke. MR spectroscopy was firstly applied for clinical examination to measure brain temperature of patients with stroke.

Research Products

• [Journal Article] Ruptured aneurysm of a posterior inferior cerebellar artery communicating artery. Case report and histological findings (2012)
  • Author(s): Sugiyama S, Fujimura M, Inoue T, Shimizu H, Watanabe M, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 52 Pages: 81-83
  • Peer Reviewed
• [Journal Article] Annual rupture risk of growing unruptured cerebral aneurysms detected by magnetic resonance angiography (2012)
  • Author(s): Inoue T, Shimizu H, Fujimura M, Saito A, Tominaga T
  • Journal Title: J Neurosurg Volume: (in press)
  • Peer Reviewed
• [Journal Article] Efficacy of prophylactic blood pressure lowering according to a standardized postoperative management protocol to prevent symptomatic cerebral hyperperfusion after direct revascularization surgery for moyamoya disease (2012)
  • Author(s): Fujimura M, Inoue T, Shimizu H, Saito A, Mugikura S, Tominaga T
  • Journal Title: Cerebrovasc Dis Volume: 33 Pages: 436-445
  • Peer Reviewed
• [Journal Article] Hemosiderin detected by t2*-weighted magnetic resonance imaging in patients with unruptured cerebral aneurysms : Indication of previous bleeding? (2011)
  • Author(s): Takada S, Inoue T, Niizuma K, Shimizu H, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 51 Pages: 275-281
  • Peer Reviewed
• [Journal Article] Hemodynamic analysis of growing intracranial aneurysms arising from a posterior inferior cerebellar arter (2011)
  • Author(s): Sugiyama SI, Meng H, Funamoto K, Inoue T, Fujimura M, Nakayama T, Omodaka S, Shimizu H, Takahashi A, Tominaga T
  • Journal Title: World Neurosurg
  • Peer Reviewed
• [Journal Article] Subarachnoid hemorrhage due to ruptured posterior cerebral artery aneurysm simultaneously associated with multiple remote intracerebral hemorrhages-case report (2011)
  • Author(s): Sonobe S, Fujimura M, Endo H, Inoue T, Shimizu H, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 51 Pages: 836-838
  • NAID: 10030030712
  • Peer Reviewed
• [Journal Article] Cerebral blood flow after surgery for unruptured cerebral aneurysms : Effects of surgical manipulation and irrigation fluid (2011)
  • Author(s): Shimizu H, Inoue T, Fujimura M, Saito A, Tominaga T
  • Journal Title: Neurosurgery Volume: 69 Pages: 677-688
  • Peer Reviewed
• [Journal Article] Compromise of brain tissue caused by cortical venous reflux of intracranial dural arteriovenous fistulas : Assessment with diffusion-weighted magnetic resonance imaging (2011)
  • Author(s): Sato K, Shimizu H, Fujimura M, Inoue T, Matsumoto Y, Tominaga T
  • Journal Title: Stroke Volume: 42 Pages: 998-1003
  • Peer Reviewed
• [Journal Article] Predictive role of modified clinical diffusion mismatch in early neurological deterioration due to atherothrombotic ischemia in the anterior circulation (2011)
  • Author(s): Saito A, Shimizu H, Fujimura M, Inoue T, Tominaga T
  • Journal Title: Acta Neurochir(Wien) Volume: 153 Pages: 2205-2210
  • Peer Reviewed
• [Journal Article] Cerebral arteritis with extremely late onset secondary to bacterial meningitis-case report (2011)
  • Author(s): Kawaguchi T, Ogawa Y, Inoue T, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 51 Pages: 302-305
  • NAID: 10028105286
  • Peer Reviewed
• [Journal Article] [asymptomatic intracerebral hemorrhage under strict blood pressure control due to postoperative cerebral hyperperfusion in a patient with moyamoya disease] (2011)
  • Author(s): Ito A, Fujimura M, Inoue T, Tominaga T
  • Journal Title: No Shinkei Geka Volume: 39 Pages: 681-686
  • Peer Reviewed
• [Journal Article] Significance of focal cerebral hyperperfusion as a cause of transient neurologic deterioration after extracranial-intracranial bypass for moyamoya disease : Comparative study with non-moyamoya patients using n-isopropyl-p-[(123)i] iodoamphetamine single-p (2011)
  • Author(s): Fujimura M, Shimizu H, Inoue T, Mugikura S, Saito A, Tominaga T
  • Journal Title: Neurosurgery Volume: 68 Pages: 957-964
  • Peer Reviewed
• [Journal Article] Simultaneous occurrence of subarachnoid hemorrhage and epistaxis due to ruptured petrous internal carotid artery aneurysm : Association with transsphenoidal surgery and radiation therapy : Case report (2011)
  • Author(s): Endo H, Fujimura M, Inoue T, Matsumoto Y, Ogawa Y, Kawagishi J, Jokura H, Shimizu H, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 51 Pages: 226-229
  • Peer Reviewed
• [Journal Article] ruptured aneurysm at the anterior wall of the internal carotid artery in a patient with systemic lupus erythematosus and secondary antiphospholipid syndrome (2011)
  • Author(s): Chonan M, Fujimura M, Inoue T, Tominaga T
  • Journal Title: No Shinkei Geka Volume: 39 Pages: 675-680
  • Peer Reviewed
• [Journal Article] Hemosiderin detected by T2^*-weighted magnetic resonance imaging in patients with unruptured cerebral aneurysms : indication of previous bleeding? (2011)
  • Author(s): 井上敬, 他
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 51 Pages: 275-281
  • Peer Reviewed
• [Journal Article] Cerebral blood flow after surgery for unruptured cerebral aneurysms : effects of surgical manipulation and irrigation fluid (2011)
  • Author(s): 井上敬, 他
  • Journal Title: Neurosurgery Volume: 69 Pages: 677-688
  • Peer Reviewed
• [Journal Article] Predictive role of modified clinical diffusion mismatch in early neurological deterioration due to atherothrombotic ischemia in the anterior circulation (2011)
  • Author(s): 井上敬
  • Journal Title: Acta Neurochir (Wien) Volume: 153 Pages: 2205-10
  • Peer Reviewed
• [Journal Article] Acute-stage diffusion-weighted magnetic resonance imaging for predicting outcome of poor-grade aneurysmal subarachnoid hemorrhage (2010)
  • Author(s): Sato K, Shimizu H, Fujimura M, Inoue T, Matsumoto Y, Tominaga T
  • Journal Title: J Cereb Blood Flow Metab Volume: 30 Pages: 1110-1120
  • Peer Reviewed
• [Journal Article] Lectin-like oxidized low-density lipoprotein receptor 1 and matrix metalloproteinase expression in ruptured and unruptured multiple dissections of distal middle cerebral artery : Case report (2010)
  • Author(s): Saito A, Fujimura M, Inoue T, Shimizu H, Tominaga T
  • Journal Title: Acta Neurochir(Wien) Volume: 152 Pages: 1235-1240
  • Peer Reviewed
• [Journal Article] Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque (2010)
  • Author(s): Saito A, Fujimura M, Inoue T, Shimizu H, Tominaga T
  • Journal Title: Acta Neurochir(Wien) Volume: 152 Pages: 589-595
  • Peer Reviewed
• [Journal Article] De novo formation of orbital cavernous malformation 9 years after surgical management of dural arteriovenous fistula in the anterior middle fossa : Case report (2010)
  • Author(s): Omodaka S, Fujimura M, Endo T, Inoue T, Shimizu H, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 50 Pages: 324-327
  • NAID: 10026192340
  • Peer Reviewed
• [Journal Article] Paradoxical association of moyamoya syndrome with large middle cerebral artery aneurysm and subarachnoid hemorrhage. Case report (2010)
  • Author(s): Endo H, Fujimura M, Inoue T, Shimizu H, Tominaga T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 50 Pages: 1088-1091
  • NAID: 10027123882
  • Peer Reviewed
• [Journal Article] Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque (2010)
  • Author(s): 井上敬, 他
  • Journal Title: Acta Neurochir (Wien) Volume: 152 Pages: 589-595
  • Peer Reviewed
• [Journal Article] Lectin-like oxidized low-density lipoprotein receptor 1 and matrix metall oproteinase expression in ruptured and unruptured multiple dissections of distal middle cerebral artery : case report (2010)
  • Author(s): 井上敬, 他
  • Journal Title: Acta Neurochir (Wien) Volume: 152 Pages: 1235-1240
  • Peer Reviewed
• [Journal Article] Acute-stage diffusion-weighted magnetic resonance imaging for predicting outcome of poor-grade aneurysmal subarachnoid hemorrhage (2010)
  • Author(s): 井上敬, 他
  • Journal Title: JCBFM (印刷中)
  • Peer Reviewed
• [Journal Article] Simple assessment of cerebral hemodynamics using single-slab 3d time-of-flight mr angiography in patients with cervical internal carotid artery steno-occlusive diseases : Comparison with quantitative perfusion single-photon emission ct (2009)
  • Author(s): Hirooka R, Ogasawara K, Inoue T, Fujiwara S, Sasaki M, Chida K, Ishigaki D, Kobayashi M, Nishimoto H, Otawara Y, Tsushima E, Ogawa A
  • Journal Title: AJNR Am J Neuroradiol Volume: 30 Pages: 559-563
  • Peer Reviewed
• [Journal Article] Simple assessment of cerebral hemodynamics using single-slab 3D time-of-flight MR angiography in patients with cervical internal carotid artery steno-occlusive diseases : comparison with quantitative perfusion single-photon emission CT (2009)
  • Author(s): 井上敬, 他
  • Journal Title: AJNR 30 Pages: 559-563
  • Peer Reviewed
• [Presentation] 静脈血採血スペクトによる脳血流量定量法 (2011)
  • Author(s): 井上敬
  • Place of Presentation: 京都
  • Year and Date: 2011-07-31
• [Presentation] 頭部外傷後の遷延性意識障害症例に対する3T-MRI評価 (2010)
  • Author(s): 井上敬
  • Organizer: 第33回日本脳神経外傷学会
  • Place of Presentation: 京
  • Year and Date: 2010-03-05
• [Presentation] Preoperative evaluation of cerebral blood flow and metabolism in patients with arteriovenous malformation using 3. 0T magnetic resonance imaging (2009)
  • Author(s): 井上敬
  • Organizer: 国際脳卒中学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-11
• [Presentation] Preoperative evaluation of cerebral blood flow and metabolism in patients with arteriovenous malformation using 3.0T magnetic resonance imaging (2009)
  • Author(s): 井上敬, 他
  • Organizer: 国際脳卒中外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-11
• [Book] ブレインナーシング (2011)
  • Author(s): 井上敬
  • Total Pages: 230
  • Publisher: メディカ出版
• [Book] functional MRIでの言語野同定の限界 (2010)
  • Author(s): 井上敬
  • Publisher: 株式会社シナジー
• [Book] 脳神経検査のグノーティ・セアウトンpart 1 (2010)
  • Author(s): 井上敬, 他
  • Total Pages: 211
  • Publisher: 株式会社シナジー
• [Book] functional MRIでの言語野同定の限界
  • Author(s): 井上敬, 他
  • Publisher: 株式会社シナジー(印刷中)