| Project/Area Number |
21591833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松村 明 筑波大学, 大学院・人間総合科学研究科, 教授 (90241819)
鶴嶋 英夫 筑波大学, 大学院・人間総合科学研究科, 講師 (50315470)
大根田 修 筑波大学, 大学院・人間総合科学研究科, 教授 (30311872)
山下 年晴 筑波大学, 大学院・人間総合科学研究科, 助教 (50400677)
長野 真澄 筑波大学, 大学院・人間総合科学研究科, 研究員 (30436282)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生医療 / 脳梗塞 / 脳血管障害 / 脳神経疾患 / 血管内皮前駆細胞 / 動物モデル / 機能的血管内皮前駆細胞 / 一過性脳梗塞モデル |
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| Research Abstract |
In this study, we evaluated the therapeutic effect of EPCs with low aldehyde dehydrogenase activity(Alde-Low EPCs) in rats with acute cerebral infarction, and our results provide insight that may help to identify a therapeutic mechanism of EPCs for acute cerebral infarction. The administration of Alde-Low EPCs into rats with acute cerebral infarction results in the accumulation and migration of the Alde-Low EPCs into the infarct area and the subsequent decrease of infarct volume. Moreover, we found that the stromal cell-derived factor-1(SDF-1) and CXC chemokine receptor 4(CXCR4) signaling pathway may regulate the accumulation of Alde-Low EPCs. The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction.
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