| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Elucidating the mechanisms of neurogenesis after ischemia is crucial for the development of regenerative therapy for stroke. Brain-type fatty acid binding protein(B-FABP) is supposed to regulate neurogenesis during development and to have a cytoprotective role ; however, the roles on neurogenesis and neuronal injury after ischemia have not been studied well. In this study, we used a mouse forebrain ischemia model, and examined expression change of B-FABP after ischemia. In addition, we evaluated the effects of B-FABP gene knockout on neurogenesis and neuronal injury after ischemia. The current study revealed that B-FABP is expressed in neuronal stem cells, and regulates proliferation of neuronal stem cells under physiological and ischemic conditions, though the role of B-FABP on ischemic neuronal injury is not evident.
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