Roles of FABP and its regulating factors on neurogenesis after ischemia
| Project/Area Number |
21591834
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
SUGITA Masao 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (70235886)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KINOUCHI Hiroyuki 山梨大学, 医学工学総合研究部, 教授 (30241623)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 脳虚血 / 脂肪酸結合蛋白 / 神経新生 / 神経細胞保護 |
|---|
| Research Abstract |
Elucidating the mechanisms of neurogenesis after ischemia is crucial for the development of regenerative therapy for stroke. Brain-type fatty acid binding protein(B-FABP) is supposed to regulate neurogenesis during development and to have a cytoprotective role ; however, the roles on neurogenesis and neuronal injury after ischemia have not been studied well. In this study, we used a mouse forebrain ischemia model, and examined expression change of B-FABP after ischemia. In addition, we evaluated the effects of B-FABP gene knockout on neurogenesis and neuronal injury after ischemia. The current study revealed that B-FABP is expressed in neuronal stem cells, and regulates proliferation of neuronal stem cells under physiological and ischemic conditions, though the role of B-FABP on ischemic neuronal injury is not evident.
|
Report
(4 results)
Research Products
(1 results)
