| Project/Area Number |
21591836
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University |
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Principal Investigator |
MIYACHI Shigeru 名古屋大学, 大学院・医学系研究科, 准教授 (00293697)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Takehiro 名古屋大学, 医学部附属病院, 医員
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 未破裂脳動脈瘤 / 破裂リスク / コンピューターシミュレーション / 三次元画像 / MRI / 血流解析 / wall shear stress / MRi / 脳動脈瘤 / computer fluid dynamics / MR fluid dynamics / 破裂 / 増大 / 血管モデル / 剪断力 |
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| Research Abstract |
BACKGROUND : Hemodynamics in intracranial aneurysms is thought to play an important role in their growth and rupture. Usual computed fluid dynamics(CFD) based on three-dimensional(3D) computed tomographic(CT) angiography requires a time-consuming process for analysis. Magnetic resonance fluid dynamics(MRFD) based on MR images is a new tool for analyzing flow dynamics and a promising method for obtaining such information more easily. We compared the data from MRFD and CFD and studied the clinical feasibility of MRFD.
METHODS : A total of15aneurysms, including two ruptured ones, in15patients were investigated with MR imaging and 3D-CT angiography. The flow data of MRFD and CFD, 3D stream lines, flow velocity profile and wall shear stress(WSS) were extracted from the image reconstruction and were compared each other.
RESULTS : Both flow dynamics images showed quite similar 3D flow pattern and WSS map. However, the calculated value of maximum WSS was quite different and there was no significant correlation. Further, in one ruptured case, CFD showed less visualization to evaluate the intra-aneurysmal flow.
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