Facial nerve regeneration by suppression of axon growth inhibition signals

Research Project

Project/Area Number	21591838
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Kobe University
Principal Investigator	TANIGUCHI Masaaki 神戸大学, 医学部附属病院, 講師 (60346195)
Co-Investigator(Kenkyū-buntansha)	KOHMURA Eiji 神戸大学, 医学研究科, 教授 (30225388) KONDOH Takeshi 神戸大学, 医学研究科, 医学研究員 (50273769)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	実験脳外科学 / 顔面神経再生 / 軸索再生阻害因子 / プロテオグリカン / 顔面神経 / コンドロイチナーゼ / RGM / 軸策再生阻害因子 / 末梢神経再生
Research Abstract	The present study demonstrated enhanced recovery of the rat facial nerve function after transection and suturing of the facial nerve by degradation of proteoglycan by chondroitinase injection. The degree of the recovery was, however, only up to 40% of the normal side. Manual stimulation in combination with the chondroitinase injection resulted in additional recovery of about 20%.

Report

(4 results)