The Investigation of tumor suppression effect of EP4 receptor inhibitors in glioblastoma

• Project/Area Number: 21591839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tottori University
• Principal Investigator: WATANABE Takashi 鳥取大学, 医学部, 教授 (00175100)
• Co-Investigator(Kenkyū-buntansha): KAMBE Atsushi 鳥取大学, 医学部, 助教 (70348283)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 膠芽腫 / プロスタグランジンE2受容体EP4 / EGFR / 脳・神経 / 脳神経疾患 / 癌

Research Abstract

We have investigated the tumor suppression effects of selective inhibitors of Prostaglandin E2 receptor, EP4 in human glioblastoma cells. The EP4 expression in malignat gliomas were higher relative to the lower grade gliomas on Immunohistochemistry staining and Western blotting analysis. The selective EP4 receptor inhibitors ONO-AE3-208 and ONO-AE1-328 exhibited the effects of tumor proliferation suppression, tumor invasion suppression and apoptosis induction at high-dose concentrations(50-100uM). They indicated the necessity of further conditional investigations to perform in vivo experiments.

Research Products

• [Presentation] The COX inhibitor, sulindac sulfide inhibits EP4 expression and suppresses the growth of Glioblastoma cells (2011)
  • Author(s): 神部敦司
  • Organizer: 12^<th> International Conference on Bioactive Lipids in Cancer
  • Place of Presentation: Seattle, USA
  • Year and Date: 2011-09-19
• [Presentation] The cyclooxygenase inhibitors inhibit EP4 expression and suppresses the growth of glioblastoma cells (2010)
  • Author(s): 神部敦司
  • Organizer: Joint Neurosurgical Convention 2010
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-01-25
• [Presentation] The cyclooxygenase inhibitors inhibit EP4 expression and suppresses the growth of glioblastoma cells. (2010)
  • Author(s): 神部敦司
  • Organizer: Joint Neurosurgical Convention 2010
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-01-25