The effect of CYR61 expression on oncolytic viral treatment for malignant glioma
| Project/Area Number |
21591841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
SUGIU Kenji 岡山大学, 岡山大学病院, 講師 (40325105)
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| Co-Investigator(Kenkyū-buntansha) |
KUROZUMI Kazuhiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20509608)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 悪性グリオーマ / オンコリティックウイルス / CYR61 / 細胞微小環境 / 腫瘍血管新生 |
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| Research Abstract |
We are studying oncolytic viral(OV) therapy as a new therapeutic modality for malignant glioma. In OV therapy-induced changes of the several proangiogenic factors, we confirmed the significant, induction of cysteine-rich protein 61(CYR61) gene expression in tumors treated to OV. We are exploring the influence of angiotome such as CYR61 on OV therapy and continue to make new OV.
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Report
(4 results)
Research Products
(129 results)
