| Project/Area Number |
21591844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SATOMI Junichiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (10304510)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAHIRO Shinji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60145315)
KANEMATSU Yasuhisa 徳島大学, 病院, 助教 (90363142)
YAGI Kenji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80551837)
TADA Yoshiteru 徳島大学, 病院, 助教 (30547964)
SATA Masataka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (80345214)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳動脈瘤 / 高血圧 / エストロゲン / 炎症 / 酸化ストレス |
|---|
| Research Abstract |
Statins exert pleiotropic effects on the vasculature, independent of their cholesterol-lowering properties. In a rat model we studied whether statins prevent the initiation and growth of cerebral aneurysms. A hydrophilic statin at low dose prevented the cerebral aneurysm formation, which was associated with eNOS up-regulation. On the other hand, the statin at high doses and a lipophilic statin promoted aneurysm growth and rupture ; the deleterious effects were associated with vascular apoptosis. Our results issue a warning that statins exert bidirectional effects on cerebral aneurysms.
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