Protective effect of rare sugar D-allose on ischemic injuries occurred by brain embolism.

• Project/Area Number: 21591846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kagawa University
• Principal Investigator: TOKUDA Masaaki 香川大学, 医学部, 教授 (10163974)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Fuminori 香川大学, 医学部, 准教授 (40271085) ; ITANO Toshifumi 香川大学, 大学本部, 理事 (60145042)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 希少糖 / D-アロース / 脳梗塞 / 血液脳関門 / 虚血再還流障害 / 活性酸素 / 血管脳関門 / D-トアロース / オートラジオグラフィー

Research Abstract

We performed the experiment using a rat model with brain ischemia and reperfusion. Male SD rats weighing 350-400g were used. The ischemic model was made by placing a nylon thread in the mid brain artery for 60 min. D-allose reduces the impaired region of brain embolism in a dose dependent manner. D-allose(50mg/ kg～800mg/ kg) was administered intravenously. Oxidative stress markers were markedly reduced by D-allose. Thus, D-allose was revealed to reduce the impaired region of brain embolism in a dose-dependent manner.

Research Products

• [Journal Article] Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat (2011)
  • Author(s): Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep RF, Itano T, Miyamoto O
  • Journal Title: Neurosci Lett Volume: 487(1) Pages: 103-6
• [Journal Article] Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat (2011)
  • Author(s): Nakamura T, 他10名
  • Journal Title: Neuroscience Letters Volume: 487 Issue: 1 Pages: 103-106
  • DOI: 10.1016/j.neulet.2010.10.004
  • Peer Reviewed
• [Journal Article] Anti-oxidative effects of d-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat. (2011)
  • Author(s): Nakamura T, 他10名
  • Journal Title: Neuroscience Letters Volume: 487 Pages: 103-106
  • Peer Reviewed
• [Presentation] How the New frontier of D-psicose world has been created in Kagawa (2011)
  • Author(s): Masaaki Tokuda
  • Organizer: Rare Sugar Congress in Kagawa 2011
  • Place of Presentation: かがわ国際会議場
  • Year and Date: 2011-11-10
• [Presentation] D-allose reduces cisplatin rephrotoxicity by inhibition of tumor necrosis factor-alfa (2011)
  • Author(s): Yuki Miyawaki, 他4名
  • Organizer: Rare Sugar Congress in Kagawa 2011
  • Place of Presentation: かがわ国際会議場
  • Year and Date: 2011-11-10
• [Presentation] Rare sugar D-allose strongly induces Thioredoxin interacting protein (TXNIP) and inhibits osteoclast differentiation in Raw264 cells (2011)
  • Author(s): Fuminori Yamaguchi, 他8名
  • Organizer: Rare Sugar Congress in Kagawa 2011
  • Place of Presentation: かがわ国際会議場
  • Year and Date: 2011-11-10
• [Presentation] How the New frontier of D-psicose world has been created in Kagawa (2011)
  • Author(s): Masaaki Tokuda
  • Organizer: Rare Sugar Congress in Kagawa
• [Presentation] D-allose reduces cisplatin rephrotoxicity by inhibition of tumor necrosis factor-alfa (2011)
  • Author(s): Yuki Miyawaki, Masaaki Ueki, Takehiko Asaga, Masaaki Tokuda, Gotaro Shirakami
  • Organizer: Rare Sugar Congress in Kagawa
• [Presentation] Rare sugar D-allose strongly induces Thioredoxin interacting protein(TXNIP) and inhibits osteoclast differentiation in Raw264 cells (2011)
  • Author(s): Fuminori Yamaguchi, Kana Yamada, Chisato Noguchi, Kazuyo Kamitori, Youyi Dong, Yuko Hirata, Mohammad A Hossain, Ikuko Tsukamoto, Masaaki Tokuda
  • Organizer: Rare Sugar Congress in Kagawa
• [Presentation] 希少糖の医薬品及び食品への利用 (2009)
  • Author(s): 徳田雅明, 塚本郁子
  • Organizer: 第47回生物物理学会年会
  • Place of Presentation: 徳島文理大学 徳島キャンパス
  • Year and Date: 2009-10-30
• [Presentation] 希少糖の医薬品及び食品への利用
  • Author(s): 徳田雅明、塚本郁子
  • Organizer: 第47回生物物理学会年会
• [Remarks]
  • URL: http://www.kms.ac.jp/~physiol1/index.html
• [Remarks]
  • URL: http://www.kms.ac.jp/~kishoto/
• [Remarks]
  • URL: http://www.kms.ac.jp/~kishoto/