Effect of statins on the blood-brain barrier
| Project/Area Number |
21591848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | 独立行政法人国立病院機構長崎医療センター (2011)
Department of Clinical Research, National Hospital Organization Nagasaki Medical Center (2009-2010) |
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Principal Investigator |
MOROFUJI Yoichi 独立行政法人国立病院機構長崎医療センター, 臨床研究センター, 客員研究員 (40437869)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Kentaro 長崎大学, 医学部歯学部付属病院, 助教 (40404222)
SO Gohei 長崎大学, 医学部歯学部付属病院, 医員 (80530427)
TAKAHATA Hideaki 独立行政法人国立病院機構, 長崎医療センター・脳神経外科, 医師 (80607854)
TAKESHITA Tomonori 長崎大学, 医学部歯学部付属病院, 医員 (30597365)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | スタチン / 血液脳関門 / タイトジャンクション / 脳卒中 / blood-brain barrier / statins / tight junctions / stroke / claudin-5 / brain endothelial cells |
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| Research Abstract |
We investigated the effect of pitavastatin on barrier functions of an in vitro BBB model with primary cultures of rat brain capillary endothelial cells(RBEC). Our data indicate that pitavastatin strengthens the barrier integrity in primary cultures of RBEC. The BBB-stabilizing effect of pitavastatin may be mediated partly through inhibition of the mevalonate pathway and subsequent up-regulation of claudin-5 expression.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Pitavastatin Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells2010
Author(s)
Morofuji Y, Nakagawa S, So G, Hiu T, Horai S, Hayashi K, Tanaka K, Suyama K, Deli MA, Nagata I, Niwa M.
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Journal Title
Cell Mol Neurobiol
Volume: 30(5)
Pages: 727-35
NAID
Related Report
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[Presentation] The Effects of Statins on Blood-Brain Barrier-Possibility of therapeutic option for stroke-(oral presentation)2010
Author(s)
Y. Morofuji, S. Nakagawa, S. Horai, G. So, K. Tsutsumi, H. Baba, K. Suyama, I. Nagata, M. Niwa
Organizer
3rd International Conference on Hypertension, Lipids, Diabetes and Stroke Prevention
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Preoperative Platelet Aggregation Predicts Periprocedual Complications in Neuroendovascular Surgery2010
Author(s)
Yoichi Morofuji, Gohei So, Takeshi Hiu, Junichi Kawakubo, Nobutaka Horie, Kentaro Hayashi, Hideaki Takahata, Naoki Kitagawa, Kazuhiko Suyama, Izumi Nagata
Organizer
The 10^th Korean and Japanese Friendship Conference on Surgery for Cerebral Stroke Huis Ten Bosch
Place of Presentation
Sasebo, Nagasaki, Japan
Related Report
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