| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Our study shows the expression of COX-2 in the cerebral aneurysm(CA) wall and suggests that this protein is involved in CA pathogenesis. Chronic inflammation due to COX-2 expression is thought to be the main cause of CA rupture, and our study suggests the possibility for medically treating unruptured CAs with a COX-2 inhibitor. In future, the administration of specific prostanoids receptor inhibitors could become the first-choice therapy for patients with unruptured CAs.
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