| Project/Area Number |
21591853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Nobutaka 横浜市立大学, 医学研究科, 教授 (60214673)
KANNO Hiroshi 横浜市立大学, 医学研究科, 客員准教授 (40244496)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | Caveolin-1 / 脳虚血 / プレコンディショニング / 虚血耐性 / 全脳虚血 / CAVEOLIN-1 |
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| Research Abstract |
The cerebral ischemic preconditioning didn' t work in Caveolin-1 knockout mice and their cerebrovascular volume in the hippocampi was reduced. Their collateral formation of Willis ring was higher than WT mice, which might be a compensating mechanism. And in the hippocampi of young Caveolin-1 knockout mice, the synapse signaling components were reduced and neurodegenerative changes indicative Alzheimer's disease were seen, which are generally related to aging. Additionally, neuron-targeted Caveolin-1 re-expression in caveolin-1 knockout neurons in vitro decreased amyloid beta protein expression. These data suggests loss of cavolin-1 accelerates neurodegeneration and aging.
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