Simultaneous measurement for brain disease by the combined system of Low field Magnetic resonance images and micro Magnetoencephalogram

• Project/Area Number: 21591855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka City University
• Principal Investigator: TSUYUGUCHI Naohiro 大阪市立大学, 大学院・医学研究科, 准教授 (50295705)
• Co-Investigator(Kenkyū-buntansha): TAKAMI Toshihiro 大阪市立大学, 大学院・医学研究科, 講師 (20305626) ; OHATA Kenji 大阪市立大学, 大学院・医学研究科, 教授 (70194264) ; ADACHI Yoshiaki 金沢工業大学, 付属研究所 (80308585)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 神経科学 / 脳神経疾患 / MEG / MRI / SQUID / 脳磁図 / micro SQUID / rat / 低磁場 / てんかん

Research Abstract

This study aims to establish the simultaneous measurement of MEG and MRI combined system by the passive and active sensing of SQUID. We are now developing a low field MRI system which can be integrated with the MEG system for small animals. This micro SQUID MEG system could detect femtotesla magnetic fields of epileptic spike and evoked potential in rat brains. The SQUID MRI could detect the T1 signal of water and lipid in low field magnetic field, furthermore clearly separate these two signals. This result leads to construct 2D imaging by low field MRI.

Research Products

• [Journal Article] SQUID-Based Low Field MRI System for Small Animals (2011)
  • Author(s): Junichi Hatta, Masakazu Miyamoto, Yoshiaki Adachi, Member, IEEE, Jun Kawai, Gen Uehara, and Hisashi Kado
  • Journal Title: IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY Volume: 21 Pages: 526-529
• [Journal Article] Development of A SQUID-Based Low-Field NMR/MRI (2011)
  • Author(s): SystemMasakazu Miyamoto, Junichi Hatta, Daisuke Oyama, Yoshiaki Adachi, Jun Kawai, Gen Uehara, Takahiro Ohkubo
  • Journal Title: Physics Procedia Volume: 00 Pages: 1-4
• [Journal Article] SQUID-Based Low Field MRI System for Small Animals (2011)
  • Author(s): J Hatta, M Miyamoto, Y Adachi, J Kawai, G Uehara, H.Kado
  • Journal Title: IEEE Transactions on Applied Superconductivity Volume: 21 Issue: 3 Pages: 526-529
  • DOI: 10.1109/tasc.2010.2091101
  • Peer Reviewed
• [Presentation] Development of A SQUID-Based Low-Field NMR/MRI System (2011)
  • Author(s): M. Miyamoto, J. Hatta, D. Oyama, Y. Adachi, J. Kawai, G. Uehara, T. Ohkubo
  • Organizer: Superconductivity Centennial Conference
  • Place of Presentation: Hargue
  • Year and Date: 2011-09-19
• [Presentation] SQUIDによる低磁場NMR/MRI計測の信号雑音比の改善 (2011)
  • Author(s): 宮本政和, 八田純一, 小山大介, 河合淳, 樋口正法, 足立善昭, 上原弦
  • Organizer: 第26回日本生体磁気学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-04
• [Presentation] Mesurement of Magnetic Field of brain activities in Rat using modified micro SQUID system (2011)
  • Author(s): Naohiro Tsuyuguchi, Yoshiaki Adachi, Kenji Ohata, Nobuki Murayama
  • Organizer: The 34^<th> Annual Meeting of the Japan Neuroscience Society Neuroscience Society
  • Place of Presentation: Yokohama
• [Presentation] Measurement of Magnetic Field of brain activities in Rat using modified micro SQUID system (2011)
  • Author(s): Naohiro Tsuyuguchi, Yoshiaki Adachi, Kenji Ohatan, Nobuki Murayama
  • Organizer: The 34^<th> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama
• [Presentation] Measurement of magnetic field of brain activities in rat using micro SQUID (2010)
  • Author(s): Naohiro Tsuyuguchi
  • Organizer: International conference on Biomagnetism
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2010-04-01
• [Presentation] Measurement of Magnetic Evoked Field of brain activities in Rat using micro SQUID (2010)
  • Author(s): Naohiro Tsuyuguchi, Yoshiaki Adachi, Takehiro Uda, Yoshihito Shigihara, Kenji Ohatan, Jun Kawai, Gen Uehara
  • Organizer: International Conference on Biomagnetism 2010
  • Place of Presentation: Dubrinik, Croatia