a role of glial cells in the central nervous system to prevent retrograde degeneration of the facial nucleus and a mechanism for axonal regeneration
| Project/Area Number |
21591859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | facial motoneuron / retrograde degeneration / axonal injury / brainstem / glial cell / axonal injuly / axonal regeneration / facial nerve / facial nucleus / axotomy / central nervous system / stereotactic surgery / facial nerve injury / astrocyte / Schwann cell |
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| Research Abstract |
Axonal injury models throughout the facial nerve from brainstem to the target was utilized to analyze the mechanism of retrograde motoneuron degeneration and seek the preventing factors against the neuronal loss. Peripheral injury induced little motoneuron degeneration, but brainstem injury showed massive and rapid degeneration resulting in only 3% neuronal survival on day 28.Peripheral nerve autograft induced 8-times axonal survival and erythropoietin 3-times, but no other neuroprotective factors found so far. Nitric oxide was supposed to be related to the mechanism of neuronal loss but apoptosis was not. The neuroprotective mechanism for retrograde degeneration might give us the cue for CNS regeneration.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Whole genome analysis from microdissected tissue revealed adult suptratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile2011
Author(s)
Hirose Y, Sasaki H, Miwa T, Ohba S, Ikeda E, Abe M, Ikeda S, Kobayashi M, Kawase T, Hasegawa M, Yoshida K
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Journal Title
Neurosurgery
Volume: 69-2
Pages: 376-390
Related Report
Peer Reviewed
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[Presentation] 眼窩内腫瘍の外科治療2011
Author(s)
長谷川光広
Organizer
第31回日本脳神経外科コングレス総会
Place of Presentation
パシフィコ横浜(神奈川)
Year and Date
2011-05-07
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