| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Axonal injury models throughout the facial nerve from brainstem to the target was utilized to analyze the mechanism of retrograde motoneuron degeneration and seek the preventing factors against the neuronal loss. Peripheral injury induced little motoneuron degeneration, but brainstem injury showed massive and rapid degeneration resulting in only 3% neuronal survival on day 28.Peripheral nerve autograft induced 8-times axonal survival and erythropoietin 3-times, but no other neuroprotective factors found so far. Nitric oxide was supposed to be related to the mechanism of neuronal loss but apoptosis was not. The neuroprotective mechanism for retrograde degeneration might give us the cue for CNS regeneration.
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