Establishment of clinical entity about temporal lobe epilepsy with MRI-negative and PET-positive hippocampus

• Project/Area Number: 21591865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MAEHARA Taketoshi 東京医科歯科大学, 医学部附属病院, 講師 (40211560)
• Co-Investigator(Kenkyū-buntansha): 成相 直 東京医科歯科大学, 医学部附属病院, 講師 (00228090) ; 新井 信隆 剤)東京都医学研究機構, 医学(系)研究科(研究員), 参事研究員 (10167984)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 側頭葉てんかん / MRI / FDG-PET / 海馬多切術 / 海馬 / てんかん / 記銘力 / 手術成績 / 焦点

Research Abstract

The purpose of this study is to analyze characteristics of patients with intractable temporal lobe epilepsy(TLE) who have MRI-negative and PET-positive hippocampus and then to establish optimal surgical treatment in seizure outcome and memory preservation. We performed lesionectomy and hippocampal transection for TLE patients with benign brain tumors and cavernous angiomas who have MRI-negative and PET-positive hippocampus. All patients obtained seizure-free outcome and preservation of memory function at 2years after surgery.

Research Products

• [Journal Article] Mismatchnegativity for speech sounds in temporallobe epilepsy (2012)
  • Author(s): Hara, K. Ohta, K. Miyajima, M. Hara, M. Iino, H. Matsuda, A. Watanabe, S. Matsushima, E. Maehara, T. Matsuura, M.
  • Journal Title: Epilepsy Behav Volume: 23 Pages: 335-341
  • Peer Reviewed
• [Journal Article] Mismatch negativity for speech sounds in temporal lobe epilepsy (2012)
  • Author(s): Hara, K., Ohta, K., Miyajima, M., Hara, M., Iino, H., Matsuda, A., Watanabe, S., Matsushima, E., Maehara, T., Matsuura, M.
  • Journal Title: Epilepsy Behav Volume: 23 Issue: 3 Pages: 335-341
  • DOI: 10.1016/j.yebeh.2012.01.019
  • Peer Reviewed
• [Journal Article] Abnormal mismatch negativity forpure-tone sounds in temporal lobeepilepsy (2011)
  • Author(s): Miyajima M, Ohta K, Hara K, Iino H, Maehara T, Hara M, Matsuura M, Matsushima E.
  • Journal Title: Epilepsy Res Volume: 94 Pages: 149-157
  • Peer Reviewed
• [Journal Article] Preoperative factorsassociated with antiepileptic drugwithdrawal following surgery forintractable temporal lobe epilepsy (2011)
  • Author(s): Maehara T, Ohno K.
  • Journal Title: Neurol Med Chir Volume: 51 Pages: 344-8
  • Peer Reviewed
• [Journal Article] Intraoperative Monitoring of epileptic foci : usefulness of multimodality image-guided epilepsy surgery performed in combination with electrocorticography (2011)
  • Author(s): Maehara T.
  • Journal Title: Brain Nerve Volume: 63(4) Pages: 321-9
  • NAID: 40018773077
• [Journal Article] Intraoperative Monitoring of epileptic foci : usefulness of multimodality image-guided epilepsy surgery performed in combination with electrocorticography (2011)
  • Author(s): Maehara T
  • Journal Title: Brain Nerve Volume: 63 Pages: 321-329
  • NAID: 40018773077
• [Journal Article] Preoperative factors associated with antiepileptic drug withdrawal following surgery for intractable temporal lobe epilepsy (2011)
  • Author(s): Maehara T, Ohno K
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 51 Pages: 344-348
  • NAID: 10029137876
  • Peer Reviewed
• [Journal Article] Abnormal mismatch negativity for pure-tone sounds in temporal lobe epilepsy (2011)
  • Author(s): Miyajima M, Ohta K, Hara K, Iino H, Maehara T, Hara M, Matsuura M, Matsushima E
  • Journal Title: Epilepsy Res Volume: 94 Issue: 3 Pages: 149-157
  • DOI: 10.1016/j.eplepsyres.2011.01.009
  • Peer Reviewed
• [Journal Article] てんかん原生領域への脳機能画像を用いたアプローチ (2010)
  • Author(s): 前原健寿、成相直、田中洋次、大野喜久郎
  • Journal Title: 臨床脳波 Volume: 52 Pages: 628-635
• [Journal Article] An autopsycase presenting repetitive hypoglycemiaand unique cortical dysplasia (2010)
  • Author(s): Hayashi M, Hachiya Y, Arai N
  • Journal Title: Brain Dev Volume: 32 Pages: 289-92
  • Peer Reviewed
• [Journal Article] 迷走神経刺激によるてんかん治療 (2009)
  • Author(s): 前原健寿
  • Journal Title: 臨床精神医学 38 Pages: 1739-1745
• [Presentation] MRI病変を有しない側頭葉外てんかんの焦点診断と長期手術成績 (2012)
  • Author(s): 前原健寿、稲次基希、田中洋次、大野喜久郎
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-20
• [Presentation] てんかん外科手術検討例の発作時ビデオ脳波モニタリング (2011)
  • Author(s): 前原健寿、稲次基希、菅原祐之、原恵子、松浦雅人、大野喜久郎
  • Organizer: 第41回日本臨床神経生理学会ワークショップ
  • Place of Presentation: 静岡
  • Year and Date: 2011-11-11
• [Presentation] てんかん外科手術検討例の発作時ビデオ脳波モニタリングワークショップ (2011)
  • Author(s): 前原健寿, 他
  • Organizer: 第41回日本臨床神経生理学会
  • Place of Presentation: 静岡
  • Year and Date: 2011-11-11
• [Presentation] てんかん焦点検査の低侵襲診断手術および手術成績に対する有用性の検証特別シンポジウム (2011)
  • Author(s): 前原健寿、成相直、田中洋次、稲次基希、石井賢二、石渡喜一、大野喜久郎
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-13
• [Presentation] 側頭葉切除患者におけるFDG-PET、flumazenil-PET統計学的解析 (2011)
  • Author(s): 前原健寿、成相直、田中洋次、稲次基希、石井賢二、石渡喜一,日浦幹夫,大野喜久郎
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-07
• [Presentation] 側頭葉切除患者における中枢性ベンゾジアゼピン受容体拮抗薬flumazenil-PET統計学的解析 (2011)
  • Author(s): 前原健寿, 他
  • Organizer: 第5回日本てんかん学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-18
• [Presentation] 最新の神経画像検査を用いた側頭葉疾患の多機能画像診断 (2011)
  • Author(s): 前原健寿
  • Organizer: 第31回日本脳神経外科コングレス総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-05-07
• [Presentation] 最新の神経画像検査を用いた側頭葉疾患の多機能画像診断 (2011)
  • Author(s): 前原健寿
  • Organizer: 第31回日本脳神経外科コングレス総
  • Place of Presentation: 横浜
  • Year and Date: 2011-05-07
• [Presentation] 慢性頭蓋内脳波記録とPET統計学的解析を用いた側頭葉てんかん術後発作残存の検討 (2011)
  • Author(s): 前原健寿、成相直、石井賢二、石渡喜一、大野喜久郎
  • Organizer: 第34回日本てんかん外科学会シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2011-01-20
• [Presentation] Kikuo Ohno Hippocampal transection for temporal lobeepilepsy patients with organic lesions and MRI-normal hippocampus (2010)
  • Author(s): Taketoshi Maehara, Tadashi Nariai, Yoji Tanakai, Keiko Hara, Miho Miyajima, Satsuki Wtanabe, Masato Matsuura
  • Organizer: 64th annualmeeting of the American Epilepsy Society
  • Place of Presentation: USA
  • Year and Date: 2010-12-05
• [Presentation] Hippocampal transection for temporal lobe epilepsy patients with organic lesions and MRI-normal hippocampus (2010)
  • Author(s): Taketoshi Maehara
  • Organizer: 64th annual meeting of the American Epilepsy Society
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 2010-12-05
• [Presentation] Neuroimagingによる大脳皮質形成障害のてんかん病態解析 (2010)
  • Author(s): 前原健寿、成相直、田中洋次、石井賢二、石渡喜一、大野喜久郎
  • Organizer: 第40回日本臨床神経生理学会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-02
• [Presentation] Neuroimagingによる大脳皮質形成障害のてんかん病態解析 (2010)
  • Author(s): 前原健寿
  • Organizer: 第40回日本臨床神経生理学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-02
• [Presentation] Functional distribution of the palmsensory area using intraoperativeintrinsic optical imaging (2010)
  • Author(s): Taketoshi Maehara, Motoki Inaji, Tadashi Nariai, Katsushige Sato, Kikuo Ohno
  • Organizer: 29^thinternational congress of clinicalneurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 2010-10-30
• [Presentation] 側頭葉てんかん術後抗てんかん薬中止と発作残存に着目した長期手術成績 (2010)
  • Author(s): 前原健寿、田中洋次、大野喜久郎
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-28
• [Presentation] 側頭葉てんかん術後抗てんかん薬中止と発作残存に着目した長期手術成績 (2010)
  • Author(s): 前原健寿
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2010-10-28
• [Presentation] 側頭葉てんかん患者におけるFDG-PET統計学的解析を用いた局所脳機能異常ネットワーク解析 (2010)
  • Author(s): 前原健寿、成相直、田中洋次、石井賢二、石渡喜一、大野喜久郎
  • Organizer: 第44回日本てんかん学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-10-14
• [Presentation] 側頭葉切除患者における中枢性ベンゾジアゼピン受容体拮抗薬flumazenil-PET統計学的解析 (2010)
  • Author(s): 前原健寿、成相直、田中洋次、稲次基希、石井賢二、石渡喜一、日浦幹夫,松浦雅人、大野喜久郎
  • Organizer: 第5回日本てんかん学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-18
• [Presentation] 側頭葉てんかん患者におけるFDG-PET統計学的解析を用いた側頭葉低代謝域の検討 (2010)
  • Author(s): 前原健寿、成相直、田中洋次、石井賢二、石渡喜一、大野喜久郎
  • Organizer: 第4回日本てんかん学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-12
• [Presentation] 病巣切除と海馬到達のための側頭葉先端病変への種々のapproach (2010)
  • Author(s): 前原健寿
  • Organizer: 第6回nuorosurgical video conference
  • Place of Presentation: 東京
  • Year and Date: 2010-02-12
• [Presentation] 器質性病変とMRI陰性PET陽性海馬を有する側頭葉てんかんに対する海馬多切術の検討 (2010)
  • Author(s): 前原健寿、成相直、田中洋次、長崎弘和、石井賢二、石渡喜一、大野喜久郎
  • Organizer: 第33回日本てんかん外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-21
• [Presentation] 教育講演「側頭葉外てんかん」 (2010)
  • Author(s): 前原健寿
  • Organizer: 第33回日本てんかん外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-21
• [Presentation] てんかん原生領域診断への脳機能画像を用いたアプローチ (2009)
  • Author(s): 前原健寿
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 小倉
  • Year and Date: 2009-11-19
• [Presentation] MRI病変を有するてんかん患者におけるPETナビゲーション下の 術中皮質脳波 (2009)
  • Author(s): 前原健寿
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 小倉
  • Year and Date: 2009-11-19
• [Presentation] Kikuo Ohno C11-flumazenil and F18-fluorodeoxyglucose (2009)
  • Author(s): Taketoshi Maehara, Tadashi Nariai, Motoki Inaji, Yoji Tanaka, Hirokazu Nagasaki, Kenji Ishii, Kiich Ishiwata
  • Organizer: PETco-registration for image-guidedsurgery in patients with lesionalepilepsy AESC
  • Place of Presentation: Osaka
  • Year and Date: 2009-06-19
• [Presentation] C11-flumazenil and F18-fluorodeoxyglucose PET co-registration for image-guided surgery in patients with lesional epilepsy (2009)
  • Author(s): 前原健寿
  • Organizer: AESC 2009
  • Place of Presentation: Osaka
  • Year and Date: 2009-06-19