| Project/Area Number |
21591870
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
|
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| Research Institution | Osaka University |
|---|
Principal Investigator |
KAGAWA Naoki 大阪大学, 医学系・研究科, 助教 (50444542)
|
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| Co-Investigator(Kenkyū-buntansha) |
HOSEN Naoki 大阪大学, 医学系・研究科, 准助教 (10456923)
HASHIMOTO Naoya 大阪大学, 医学系・研究科, 准助教 (90315945)
YOSHIMINE Toshiki 大阪大学, 医学系・研究科, 教授 (00201046)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KINOSHITA Manabu 大阪大学, 医学系・研究科, 助教 (40448064)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 腫瘍幹細胞 / 悪性脳腫瘍 / 分子標的薬剤 / 腫瘍発生 / 治療耐性 |
|---|
| Research Abstract |
In this study, we showed that CD166/ activated leukocyte cell adhesion molecule(ALCAM) was highly expressed on glioblastoma progenitor cells. ALCAM^+ CD133^+ cells were highly enriched with tumor-sphere-initiating cells in vitro. The investigation about the in vitro and in vivo function of ALCAM in glioblastoma cells demonstrated ALCAM and its soluble isoform may be involved in invasion, progression and angiogenesis in glioblastomas and can result in poor prognosis or resistance against chemo-radiotherapies. Development of molecular targeting therapy against souble ALCAM should be planned in the future.
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