Investigation of new treatment target genes for GBM based on classification of GBM stem cells

• Project/Area Number: 21591874
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: HIDE Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820)
• Co-Investigator(Kenkyū-buntansha): KURATSU Jun-ichi 熊本大学, 大学院・生命科学研究部, 教授 (20145296) ; NAKAMURA Hideo 熊本大学, 医学部附属病院, 助教 (30359963) ; MAKINO Keishi 熊本大学, 大学院・生命科学研究部, 助教 (90381011)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 癌幹細胞 / 神経膠芽腫 / 培養 / 治療

Research Abstract

Seven of GBM stem cell from human GBM tissues were established. Classification of GBM stem cells is going now. A candidate of GBM stem cell marker was identified, which highly expressed in perivasucular area and invasion front where GBM stem cells and niche exist. Characterization of this gene for GBM stem cells is going on.

Research Products

• [Journal Article] Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MGMT status (2012)
  • Author(s): Makino K, Nakamura H, Hide T, Kuratsu J
  • Journal Title: J Neurooncol Volume: 106(1) Pages: 155-60
  • NAID: 120005254835
  • Peer Reviewed
• [Journal Article] Salvage treatment with temozolomide in refractory or relapsed primary central nervous system lymphoma and assessment of the MG MT status (2012)
  • Author(s): Makino K, Nakamura H, Hide T, et al
  • Journal Title: J Neurooncol Volume: 106 Pages: 155-60
  • NAID: 120005254835
  • Peer Reviewed
• [Journal Article] Essential role of the Hedgehog signaling pathway in human glioma-initiating cells (2011)
  • Author(s): Takezaki T, Hide T, Takanaga H, Nakamura H, Kuratsu JI, Kondo T
  • Journal Title: Cancer Sci Volume: 29 Pages: 1306-1312
  • NAID: 10029295137
  • Peer Reviewed
• [Journal Article] Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells (2011)
  • Author(s): Hide T, Takezaki T, Nakatani Y, Nakamura H, Kuratsu J, Kondo T
  • Journal Title: Stem Cells Volume: 29 Pages: 590-9
  • Peer Reviewed
• [Journal Article] Risk of primary childhood brain tumors related to season of birth in Kumamoto Prefecture (2011)
  • Author(s): Makino K, Nakamura H, Hide T, Kuratsu J
  • Journal Title: Childs Nerv. Syst Volume: 27 Pages: 75-78
  • Peer Reviewed
• [Journal Article] プロラクチノーマに対する内視鏡下被膜摘出術の有用性と問題点 (2011)
  • Author(s): 矢野茂敏, 秀拓一郎, 倉津純一
  • Journal Title: 日本内分泌学会雑誌 Volume: 87巻 Pages: 64-66
• [Journal Article] Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells (2011)
  • Author(s): Hide T, et al
  • Journal Title: Stem Cells Volume: 29 Pages: 590-599
  • Peer Reviewed
• [Journal Article] Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells. (2011)
  • Author(s): Hide T., et al.
  • Journal Title: Stem Cells Volume: 4 Pages: 590-599
  • Peer Reviewed
• [Journal Article] Essential role of the Hedgehog signaling pathway in human glioma-initiating cells (2011)
  • Author(s): Takezaki T., et al.
  • Journal Title: Cancer Science Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Risk of primary childhood brain tumors related to season of birth in Kumamoto Prefecture, Japan. (2011)
  • Author(s): Makino K., et al
  • Journal Title: Childs Nerv Syst. Volume: 27 Pages: 75-78
  • NAID: 120003913473
  • Peer Reviewed
• [Journal Article] 内視鏡単独下垂体腫瘍摘出術の進歩経験と改善から振り返った治療成績の変化 (2010)
  • Author(s): 矢野茂敏, 河野隆幸, 秀拓一郎, 工藤真励奈, 倉津純一
  • Journal Title: 日本内分泌学会雑誌 Volume: 86巻 Pages: 57-59
• [Journal Article] ステロイドパルス療法直後に神経症候の増悪をきたした脊髄動静脈瘻の1例 (2010)
  • Author(s): 山本文夫, 光藤尚, 伊藤康幸, 渡邉聖樹, 秀拓一郎, 森岡基浩, 平野照之, 高田明, 橋本洋一郎, 内野誠
  • Journal Title: 神経治療学 Volume: 27(1) Pages: 83-89
  • Peer Reviewed
• [Journal Article] Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation (2009)
  • Author(s): Hide T, Takezaki T, Nakatani Y, Nakamura H, Kuratsu J, Kondo T
  • Journal Title: Cancer Res Volume: 69 Pages: 7953-7959
  • Peer Reviewed
• [Journal Article] Antitumor effect of humanized anti-interleukin-6 receptor antibody(tocilizumab) on glioma cell proliferation (2009)
  • Author(s): Kudo M, Jono H, Shinriki S, Yano S, Nakamura H, Makino K, Hide T, Muta D, Ueda M, Ota K, Ando Y, Kuratsu J
  • Journal Title: J Neurosurg Volume: 111 Pages: 219-225
  • Peer Reviewed
• [Journal Article] 脳腫瘍"癌幹細胞"の発見と治療への展開 (2009)
  • Author(s): 秀拓一郎, 倉津純一
  • Journal Title: BRAIN and NERVE Volume: 61 Pages: 781-789
  • Peer Reviewed
• [Journal Article] 脳腫瘍"癌幹細胞"の発見と治療への展開 (2009)
  • Author(s): 秀拓一郎, 倉津純一
  • Journal Title: Brain and Nerve 61 Pages: 781-789
• [Journal Article] Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation (2009)
  • Author(s): 秀拓一郎, et al.
  • Journal Title: Cancer Research 69 Pages: 7953-7959
  • Peer Reviewed
• [Journal Article] Antitumor effect of humanized anti-interleukin-6 receptor antibody(tocilizumab)on glioma cell proliferation (2009)
  • Author(s): Kudo M., et al
  • Journal Title: J Neurosurg 111 Pages: 219-225
  • Peer Reviewed
• [Presentation] 非機能性下垂体腺腫に対する内視鏡的拡大蝶形骨洞手術の適応について (2012)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第21回日本間脳下垂体腫瘍学会
  • Place of Presentation: 東京ステーションコンファレンス(東京)
  • Year and Date: 2012-02-25
• [Presentation] 非機能性下垂体腺腫に対する内視鏡的拡大蝶形骨洞手術の適応について (2012)
  • Author(s): 秀拓一郎
  • Organizer: 第21回日本間脳下垂体腫瘍学会
  • Place of Presentation: 東京ステーションコンファレンス(東京都)
  • Year and Date: 2012-02-25
• [Presentation] 膠芽腫幹細胞～膠芽腫の治療の現状と研究の展望～ (2011)
  • Author(s): 秀拓一郎
  • Organizer: GCOE特別セミナー(医科学教育セミナー)
  • Place of Presentation: 東京大学医科学研究所/2号館大講義室
  • Year and Date: 2011-12-20
• [Presentation] 膠芽腫幹細胞～膠芽腫の治療の現状と研究の展望～ (2011)
  • Author(s): 秀拓一郎
  • Organizer: GCOE特別セミナー
  • Place of Presentation: 東京大学医科学研究所/2号館大講義室(東京都)(招待講演)
  • Year and Date: 2011-12-20
• [Presentation] オリゴデンドロサイト前駆細胞の形質転換に伴う遺伝子発現の変化 (2011)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第29回日本脳腫瘍学会
  • Place of Presentation: 水明館(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] オリゴデンドロサイト前駆細胞の形質転換に伴う遺伝子発現の変化 (2011)
  • Author(s): 秀拓一郎
  • Organizer: 第29回日本脳腫瘍学会
  • Place of Presentation: 水明館(岐阜県)
  • Year and Date: 2011-11-27
• [Presentation] 中脳多房性Virchow-Robin spacesの1例 (2011)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第18回日本神経内視鏡学会
  • Place of Presentation: ホテルグランヴィア岡山(岡山)
  • Year and Date: 2011-11-18
• [Presentation] 中脳多房性Virchow-Robin spacesの1例 (2011)
  • Author(s): 秀拓一郎
  • Organizer: 第18回日本神経内視鏡学会
  • Place of Presentation: ホテルグランヴィア岡山(岡山県)
  • Year and Date: 2011-11-18
• [Presentation] Alteration of gene expression profile in oligodendrocyte precursor cells transforming into glioma initiating cells (2011)
  • Author(s): Takuichiro Hide, et al
  • Organizer: The 12^<th> Young-Honam and Kyushu Neurosurgical Joint Meeting
  • Place of Presentation: リーガロイヤルホテル小倉(福岡)
  • Year and Date: 2011-11-12
• [Presentation] Alteration of gene expression profile in oligodendrocyte precursor cells transforming into glioma initiating cells (2011)
  • Author(s): Takuichiro Hide
  • Organizer: The 12^<th> Young-Honam and KyushuNeurosurgical Joint Meeting
  • Place of Presentation: リーガロイヤルホテル小倉(福岡県)
  • Year and Date: 2011-11-12
• [Presentation] グリオーマ幹細胞研究からのグリオーマ分子標的治療の可能性 (2011)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-10-12
• [Presentation] SNP-microarray analysis to identify new prognosis markers on glioblastoma patients (2011)
  • Author(s): Takuichiro Hide, et al
  • Organizer: International Symposium on Clinical and Basic Investigation in Glioblastoma
  • Place of Presentation: Science Museum(Valencia. Spain)
  • Year and Date: 2011-06-24
• [Presentation] SNP-microarray analysis to identify new prognosis markers on glioblastoma patients (2011)
  • Author(s): Takuichiro Hide
  • Organizer: International Symposium on Clinical and Basic Investigation in Glioblastoma
  • Place of Presentation: Science Museum Valencia (Spain)
  • Year and Date: 2011-06-24
• [Presentation] Glioblastoma-initiating cells transformed from oligodendrocyte precursor cells are sensitive for the combination of Cox2 inhibitor and EGFR inhibitor (2011)
  • Author(s): Takuichiro Hide, et al
  • Organizer: 8^<th> Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Suzhou, China
  • Year and Date: 2011-05-26
• [Presentation] Glioblastoma-initiating cells transformed from oligodendrocyte precursor cells are sensitive for the combination of Cox2 inhibitor and EGFR inhibitor (2011)
  • Author(s): Takuichiro Hide
  • Organizer: 8^<th> Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Suzhou, (China)
  • Year and Date: 2011-05-26
• [Presentation] MAP2とGFAPの発現からみたグリオブラストーマ症例の長期予後予測 (2011)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船橋(東京)
  • Year and Date: 2011-05-22
• [Presentation] MAP2とGFAPの発現からみたグリオブラストーマ症例の長期予後予測 (2011)
  • Author(s): 秀拓一郎
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-05-22
• [Presentation] 間脳発生膠芽腫の臨床的特徴 (2011)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第21回日本間脳下垂体腫瘍学会
  • Place of Presentation: 秋葉原コンベンションホール(東京)
  • Year and Date: 2011-03-12
• [Presentation] 間脳発生膠芽腫の臨床的特徴 (2011)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第21回 日本間脳下垂体腫瘍学会
  • Place of Presentation: 秋葉原コンベンションホール(東京都)
  • Year and Date: 2011-03-12
• [Presentation] グリオーマ幹細胞～新たな治療標的としての可能性～ (2011)
  • Author(s): 秀拓一郎
  • Organizer: 千葉がんシンポジウム2010
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-01-15
• [Presentation] グリオーマ幹細胞～新たな治療標的としての可能性～ (2011)
  • Author(s): 秀拓一郎
  • Organizer: 千葉がんシンポジウム2010
  • Place of Presentation: 幕張メッセ国際会議場(千葉県)
  • Year and Date: 2011-01-15
• [Presentation] 軟性鏡とナビゲーションを用いたtwo burr hole techniqueが有用であった頭蓋内多房性嚢胞の2症例 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第17回日本神経内視鏡学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2010-12-11
• [Presentation] 視床・基底核部膠芽腫の臨床的特徴 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢プリンスホテル(長野)
  • Year and Date: 2010-11-29
• [Presentation] 視床・基底核部膠芽腫の臨床的特徴 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第28回 日本脳腫瘍学会
  • Place of Presentation: 軽井沢プリンスホテルウエスト(長野県)
  • Year and Date: 2010-11-28
• [Presentation] Sox11 prevents tumorigenesis of glioma-initiating cells (2010)
  • Author(s): Takuichiro Hide, et al
  • Organizer: The 15^<th> Annual Scientific Meeting of the Society for Neuro-Oncology
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2010-11-19
• [Presentation] Sox11 prevents tumorigenesis of glioma-initiating cells. (2010)
  • Author(s): Hide T., et al
  • Organizer: The 15^<th> Annual Scientific Meeting of the Society for Neuro-Oncology
  • Place of Presentation: JW Marriott Hotel Seoul (Korea)
  • Year and Date: 2010-11-19
• [Presentation] グリオブラストーマの新規の予後予測因子の検討 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第69回日本脳神経外科学会総会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-10-28
• [Presentation] グリオブラストーマの新規の予後予測因子の検討 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第69回 日本脳神経外科学会総会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-10-28
• [Presentation] SNP-microarray法を用いたグリオブラストーマの予後因子の検討 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第11回日本分子脳神経外科学会
  • Place of Presentation: 東北大学(仙台)
  • Year and Date: 2010-08-28
• [Presentation] SNP-microarray法を用いたグリオブラストーマの予後因子の検討 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第11回 日本分子脳神経外科学会
  • Place of Presentation: 艮陵記念ホール(宮城県)
  • Year and Date: 2010-08-28
• [Presentation] Sox11 prevents tumorigenesis of glioma-initiating cells. (2010)
  • Author(s): Hide T., et al
  • Organizer: The 7^<th> Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: JW Marriott Hotel Seoul (Korea)
  • Year and Date: 2010-06-12
• [Presentation] Sox11 prevents tumorigenesis of glioma-initiating cells (2010)
  • Author(s): Takuichiro Hide, et al
  • Organizer: 7^<th> Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: JW Marriott Hotel Seoul(Seoul, Korea)
  • Year and Date: 2010-06-11
• [Presentation] 新規遺伝子を標的としたグリオブラストーマ幹細胞の治療戦略 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第28回日本脳腫瘍病理学会
  • Place of Presentation: 大阪市中央公会堂(大阪)
  • Year and Date: 2010-05-22
• [Presentation] 新規遺伝子を標的としたグリオブラストーマ幹細胞の治療戦略 (2010)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第28回 日本脳腫瘍病理学会
  • Place of Presentation: 大阪市中央公会堂(大阪府)
  • Year and Date: 2010-05-21
• [Presentation] グリオブラストーマ幹細胞に対する治療標的遺伝子 (2009)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: りんくう国際会議場(大阪)
  • Year and Date: 2009-11-08
• [Presentation] グリオブラストーマ幹細胞に対する治療標的遺伝子 (2009)
  • Author(s): 秀拓一郎, 他
  • Organizer: 第27回 日本脳腫瘍学会
  • Place of Presentation: 大阪府、全日空タワーゲートホテル大阪
  • Year and Date: 2009-11-08
• [Presentation] A Treatment-target-gene Focusing on Glioma Initiating Cells (2009)
  • Author(s): Takuichiro Hide, et al
  • Organizer: The International Symposium of Pediatric Neuro-oncology for the 50th Anniversary of Taipei Veterans General Hospital and the Annual Scientific Meeting of Chinese Medical Association
  • Place of Presentation: Taipei
  • Year and Date: 2009-10-31
• [Presentation] A Treatment -target gene Focusing on Glioma Initiating Cells (2009)
  • Author(s): 秀拓一郎, et al
  • Organizer: The International Symposium of Pediatric Neuro-oncology for the 50^<th> Anniversary of Taipei Veterans General Hospital and the Annual Scientific Meeting of Chinese Medical Association
  • Place of Presentation: Taiwan, Taipei Veterans General Hospital
  • Year and Date: 2009-10-31
• [Presentation] Establishment of artificial glioblastoma initiating cells in mice (2009)
  • Author(s): Takuichiro Hide, et al
  • Organizer: The 3^<rd> quadrennial meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2009-05-12
• [Presentation] Establishment of artificial glioblastoma initiating cells in mice (2009)
  • Author(s): 秀拓一郎, et al
  • Organizer: The 3^<rd> quadrennial meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: 神奈川県、パシフィコ横浜
  • Year and Date: 2009-05-12
• [Remarks] 文部科学省科学研究費新学術領域研究,がん研究分野の特性を踏まえた支援活動研究者紹介ホームページ(秀拓一郎)
  • URL: http://ganshien.umin.jp/public/research/spotlight/hide/index.html
• [Remarks] 文部科学省科学研究費新学術領域研究,がん研究分野の特性を踏まえた支援活動研究者紹介ホームページ(秀拓一郎)
  • URL: http://ganshien.umin.jp/public/research/spotlight/hide/index.html